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Borwon Wittayachamnankul Nattayaporn Apaijai Krongkarn Sutham Boriboon Chenthanakij Chalerm Liwsrisakun Thidarat Jaiwongkam Siriporn C. Chattipakorn Nipon Chattipakorn 《Journal of cellular and molecular medicine》2020,24(11):6485-6494
To test the hypothesis that an impaired mitochondrial function is associated with altered central venous oxygen saturation (ScvO2), venous-to-arterial carbon dioxide tension difference (delta PCO2) or serum lactate in sepsis patients. This prospective cohort study was conducted in a single tertiary emergency department between April 2017 and March 2019. Patients with suspected sepsis were included in the study. Serum lactate was obtained in sepsis, ScvO2 and delta PCO2 were evaluated in septic shock patients. Mitochondrial function was determined from the peripheral blood mononuclear cells. Forty-six patients with suspected sepsis were included. Of these, twenty patients were septic shock. Mitochondrial oxidative stress levels were increased in the high ScvO2 group (ScvO2 > 80%, n = 6), compared with the normal (70%-80%, n = 9) and low ScvO2 (<70%, n = 5) groups. A strong linear relationship was observed between the mitochondrial oxidative stress and ScvO2 (r = .75; P = .01). However, mitochondrial respiration was increased in the low ScvO2 group. In addition, mitochondrial complex II protein levels were significantly decreased in the high ScvO2 group (P < .05). Additionally, there was no correlation between serum lactate, delta PCO2, and mitochondria oxidative stress or mitochondria function. ScvO2 can be potentially useful for developing new therapeutics to reduce mitochondrial dysfunction in septic shock patient. 相似文献
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Wood plastic biocomposites of biodegradable poly(butylene succinate) (PBS) and Padauk sawdust was successfully prepared by using a twin screw extruder and an injection molding machine.The effects of water absorption and sunlight exposure on some properties of the composites were investigated.Water absorption of PBS composites was found to follow the Fick's law of diffusion,while the diffusion coefficient increased with increasing wood content.Maximum water absorption of around 4.5% was observed at 30 wt.% sawdust.Optical micrograph indicated the swelling of wood particles by around 1%-3% after 30 days of water immersion.The tensile and flexural strengths reduced slightly both under the water immersion and sunlight exposure.After 90 days of exposure,the composites clearly looked paler than the non-weathered ones.Thermal scan indicated the reduction of crystalline region due to the plasticization effect derived from water molecules. 相似文献
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