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1.
Schirmer RH Coulibaly B Stich A Scheiwein M Merkle H Eubel J Becker K Becher H Müller O Zich T Schiek W Kouyaté B 《Redox report : communications in free radical research》2003,8(5):272-275
Methylene blue has intrinsic antimalarial activity and it can act as a chloroquine sensitizer. In addition, methylene blue must be considered for preventing methemoglobinemia, a serious complication of malarial anemia. As an antiparasitic agent, methylene blue is pleiotropic: it interferes with hemoglobin and heme metabolism in digestive organelles, and it is a selective inhibitor of Plasmodium falciparum glutathione reductase. The latter effect results in glutathione depletion which sensitizes the parasite for chloroquine action. At the Centre de Recherche en Santé de Nouna in Burkina Faso, we study the combination of chloroquine with methylene blue (BlueCQ) as a possible medication for malaria in endemic regions. A pilot study with glucose-6-phosphate dehydrogenase-sufficient adult patients has been conducted recently. 相似文献
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I. Bah A. Bobo Diallo T. Camara M. L. Bah T. M. O. Diallo B. Amougou K. Kouyaté M. Bobo Diallo 《Andrologie》2009,19(4):203-208
Objective
To stick out the anatomoclinic aspects and to evaluate the therapeutic results of a series of some pelvic trauma complications is followed at the Urology-Andrology ward in the teaching hospital of Conakry.Material and method
It’s about a retrospective examined joining together 52 cases of some pelvic trauma complications in a period of five years.Results
The pelvic trauma complications were representing 3% of whole the hospitalisations during the period of study. The mean age of our patients was 33 years with extremes of 10 and 63 years. The traumas were due to accidents on the public road in 54.9% of cases. In terms of clinics, the symptomatology was essentially constituted by the acute retention of urines with 80.7% of cases and the hemorrhage (hematury and uretrorragy). The main trauma was a back urethral lesion with 82.7% of cases. All the patients profited a surgical treatment. The therapeutics has been judged after an average relapse of 52 months in terms of urinary and sexual complications. Thus, in terms of urinary complications results have been judged good in 59.6% of cases, less in 17.3% and bad in 23.7% of cases. In terms of sexual, we remarked 53.8% of good result, 25% of medium results and 21.2% (N = 11) of bad results.Conclusion
Management of urinary complication after pelvic trauma is controversy. Thus, we insist on more necessary collaboration between urologist and orthopedist because the stabilisation of the pelvic trauma is very interesting to the management. 相似文献4.
Peter E Meissner Germain Mandi Boubacar Coulibaly Steffen Witte Théophile Tapsoba Ulrich Mansmann Jens Rengelshausen Wolfgang Schiek Albrecht Jahn Ingeborg Walter-Sack Gerd Mikus Jürgen Burhenne Klaus-Dieter Riedel R Heiner Schirmer Bocar Kouyaté Olaf Müller 《Malaria journal》2006,5(1):1-5
Background
Atovaquone is part of the antimalarial drug combination atovaquone-proguanil (Malarone®) and inhibits the cytochrome bc1 complex of the electron transport chain in Plasmodium spp. Molecular modelling showed that amino acid mutations are clustered around a putative atovaquone-binding site resulting in a reduced binding affinity of atovaquone for plasmodial cytochrome b, thus resulting in drug resistance.Methods
The prevalence of cytochrome b point mutations possibly conferring atovaquone resistance in Plasmodium falciparum isolates in atovaquone treatment-naïve patient cohorts from Lambaréné, Gabon and from South Western Ethiopia was assessed.Results
Four/40 (10%) mutant types (four different single polymorphisms, one leading to an amino acid change from M to I in a single case) in Gabonese isolates, but all 141/141 isolates were wild type in Ethiopia were found.Conclusion
In the absence of drug pressure, spontaneous and possibly resistance-conferring mutations are rare. 相似文献5.
Müller O De Allegri M Becher H Tiendrebogo J Beiersmann C Ye M Kouyate B Sie A Jahn A 《PloS one》2008,3(9):e3182
Background
Insecticide-impregnated bed nets (ITNs) have been shown to be a highly effective tool against malaria in the endemic regions of sub-Saharan Africa (SSA). There are however different opinions about the role of ITN social marketing and ITN free distribution in the roll-out of ITN programmes. The objective of this study was to evaluate the effects of free ITN distribution through antenatal care services in addition to an ITN social marketing programme in an area typical for rural SSA.Methods
A cluster-randomised controlled ITN trial took place in the whole Kossi Province in north-western Burkina Faso, an area highly endemic for malaria. Twelve clusters were assigned to long-term ITN (Serena brand) social marketing plus free ITN (Serena brand) distribution to all pregnant women attending governmental antenatal care services (group A), and 13 clusters to ITN social marketing only (group B). The intervention took place during the rainy season of 2006 and thereafter. The trial was evaluated through a representative household survey at baseline and after one year. Serena ITN household ownership was the primary outcome measure.Findings
A total of 1052 households were visited at baseline in February 2006 and 1050 at follow-up in February 2007. Overall Serena ITN household ownership increased from 16% to 28% over the study period, with a significantly higher increase in group A (13% to 35%) than in group B (18% to 23%) (p<0.001).Interpretation
The free distribution of ITNs to pregnant women through governmental antenatal care services in addition to ITN social marketing substantially improved ITN household ownership in rural Burkina Faso.Trial registration
Controlled-Trials.com ISRCTN07985309 相似文献6.
Bocar Kouyaté Florent Somé Albrecht Jahn Boubacar Coulibaly Jaran Eriksen Rainer Sauerborn Lars Gustafsson Göran Tomson Heiko Becher Olaf Mueller 《Malaria journal》2008,7(1):50
Background
In the rural areas of sub-Saharan Africa, the majority of young children affected by malaria have no access to formal health services. Home treatment through mothers of febrile children supported by mother groups and local health workers has the potential to reduce malaria morbidity and mortality.Methods
A cluster-randomized controlled effectiveness trial was implemented from 2002–2004 in a malaria endemic area of rural Burkina Faso. Six and seven villages were randomly assigned to the intervention and control arms respectively. Febrile children from intervention villages were treated with chloroquine (CQ) by their mothers, supported by local women group leaders. CQ was regularly supplied through a revolving fund from local health centres. The trial was evaluated through two cross-sectional surveys at baseline and after two years of intervention. The primary endpoint of the study was the proportion of moderate to severe anaemia in children aged 6–59 months. For assessment of the development of drug efficacy over time, an in vivo CQ efficacy study was nested into the trial. The study is registered under http://www.controlled-trials.com (ISRCTN 34104704).Results
The intervention was shown to be feasible under program conditions and a total of 1.076 children and 999 children were evaluated at baseline and follow-up time points respectively. Self-reported CQ treatment of fever episodes at home as well as referrals to health centres increased over the study period. At follow-up, CQ was detected in the blood of high proportions of intervention and control children. Compared to baseline findings, the prevalence of anaemia (29% vs 16%, p < 0.0001) and malaria parameters such as prevalence of P. falciparum parasitaemia, fever and palpable spleens was lower at follow-up but there were no differences between the intervention and control group. CQ efficacy decreased over the study period but this was not associated with the intervention.Discussion
The decreasing prevalence of malaria morbidity including anaemia over the study period can be explained by an overall increase of malaria prevention and treatment activities in the study area. The lack of effectiveness of the intervention was likely caused by contamination, pre-existing differences in the coverage of malaria treatment in both study groups and an unexpectedly rapid increase of resistance against CQ, the first-line treatment drug at the time of the study.7.
Lu Guangyu Traoré Corneille Meissner Peter Kouyaté Bocar Kynast-Wolf Gisela Beiersmann Claudia Coulibaly Boubacar Becher Heiko Müller Olaf 《Malaria journal》2015,14(1):1-11
The Asia Pacific Malaria Elimination Network (APMEN) is a collaboration of 18 country partners committed to eliminating malaria from within their borders. Over the past 5 years, APMEN has helped to build the knowledge, tools and in-country technical expertise required to attain this goal. At its inaugural meeting in Brisbane in 2009, Plasmodium vivax infections were identified across the region as a common threat to this ambitious programme; the APMEN Vivax Working Group was established to tackle specifically this issue. The Working Group developed a four-stage strategy to identify knowledge gaps, build regional consensus on shared priorities, generate evidence and change practice to optimize malaria elimination activities. This case study describes the issues faced and the solutions found in developing this robust strategic partnership between national programmes and research partners within the Working Group. The success of the approach adopted by the group may facilitate similar applications in other regions seeking to deploy evidence-based policy and practice. 相似文献
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Zoungrana A Coulibaly B Sié A Walter-Sack I Mockenhaupt FP Kouyaté B Schirmer RH Klose C Mansmann U Meissner P Müller O 《PloS one》2008,3(2):e1630
Background
Besides existing artemisinin-based combination therapies, alternative safe, effective and affordable drug combinations against falciparum malaria are needed. Methylene blue (MB) was the first synthetic antimalarial drug ever used, and recent studies have been promising with regard to its revival in malaria therapy. The objective of this study was to assess the safety and efficacy of two MB-based malaria combination therapies, MB–artesunate (AS) and MB–amodiaquine (AQ), compared to the local standard of care, AS-AQ, in Burkina Faso.Methods and Findings
Open-label randomised controlled phase II study in 180 children aged 6–10 years with uncomplicated falciparum malaria in Nouna, north-western Burkina Faso. Follow-up was for 28 days and analysis by intention-to-treat. The treatment groups were similar in baseline characteristics and there was only one loss to follow-up. No drug-related serious adverse events and no deaths occurred. MB-containing regimens were associated with mild vomiting and dysuria. No early treatment failures were observed. Parasite clearance time differed significantly among groups and was the shortest with MB-AS. By day 14, the rates of adequate clinical and parasitological response after PCR-based correction for recrudescence were 87% for MB-AS, 100% for MB-AQ (p = 0.004), and 100% for AS-AQ (p = 0.003). By day 28, the respective figure was lowest for MB-AS (62%), intermediate for the standard treatment AS-AQ (82%; p = 0.015), and highest for MB-AQ (95%; p<0.001; p = 0.03).Conclusions
MB-AQ is a promising alternative drug combination against malaria in Africa. Moreover, MB has the potential to further accelerate the rapid parasite clearance of artemisinin-based combination therapies. More than a century after the antimalarial properties of MB had been described, its role in malaria control deserves closer attention.Trial Registration
ClinicalTrials.gov NCT00354380相似文献9.
Tillage,crop residue,legume rotation,and green manure effects on sorghum and millet yields in the semiarid tropics of Mali 总被引:3,自引:0,他引:3
Kouyaté Zoumana Franzluebbers Kathrin Juo Anthony S.R. Hossner Lloyd R. 《Plant and Soil》2000,225(1-2):141-151
Alternative soil management practices are needed in semi-arid West Africa to sustain soil fertility and cereal production
while reducing the need for extended fallow periods and chemical fertilizers. An experiment was conducted at the Cinzana Station
near Segou, Mali to assess the effects of tillage, crop residue incorporation and legume rotation on the growth and yield
of sorghum (Sorghum bicolor L. Moench) and pearl millet (Pennisetum glaucum L.) for a period of eight years on a loamy sand and a loam soil. The following treatments were compared under tied ridging
and the traditional open ridging: continuous cereal with crop residue removed, continuous cereal with crop residue incorporated,
cereal in rotation with cowpea (Vigna unguiculata (L.) Waip.), cereal in rotation with sesbania (Sesbania rostrata Bremek. & Oberm.), and cereal in rotation with dolichos (Dolichos lablab L.). Legumes in rotation were incorporated as green manures except cowpea which was removed after each harvest. Tied ridging
improved cereal grain yield from 1022 kg ha−1 with open ridging to 1091 kg ha−1 on the loamy sand and from 1554 kg ha−1 to 1697 kg ha−1 on the loam, when averaged across management regimes and years of cropping. Incorporation of cereal residue at the beginning
of the rainy season every other year had only small and inconsistent effects on cereal yield. Rotation with cowpea increased
cereal grain and stover yields by 18 and 25%, respectively, on the loamy sand, and by 23% and 27%, respectively, on the loam
compared to continuous cereal, when averaged across tillage regimes and years. Sesbania and dolichos performed similarly as
green manures on both soils. Incorporation of these legumes as green manure at the end of the rainy season increased cereal
grain and stover yields by 37% and 49%, respectively, on the loamy sand, and by 27% and 30%, respectively, on the loam, compared
to cereal monoculture without organic amendment, when averaged across tillage regimes and years. A significant linear increase
in cereal yield was observed during the eight years of the study on the loam soil when sesbania and dolichos green manures
were incorporated.
This revised version was published online in June 2006 with corrections to the Cover Date. 相似文献
10.
Bocar S. Baldé Fambaye N. Sow Kamarel Ba Werner Ekau Patrice Brehmer Justin Kantoussan Massal Fall Malick Diouf 《Journal of fish biology》2019,94(3):391-401
We examined growth rates and reproductive characteristics of Sardinella aurita off Senegal and other coastal areas over a 20 year period (1995–2014) to determine how they relate to variations in environmental characteristics of coastal waters. Based on fish length-frequency data and a coastal upwelling index, we found that S. aurita recruitment tends to occur during the periods of most intensive upwelling (March–April off Senegal). Peak reproduction corresponds to periods of low sea-surface temperature (in February or March). The sex ratio was remarkably consistent during the 30 year study period and so was not affected by environmental changes. We hypothesise that S. aurita takes advantage of the higher zooplankton productivity that occurs in coastal waters when upwelling brings nutrient-rich water to the surface (i.e., it increases its growth rate and accumulates energy reserves for spawning). Growth performance appears to be strongly dependent on environmental conditions. The timing of spawning seems to occur when food (zooplankton) is most available for supplying the energy requirements needed by adults for spawning and early development of larvae. Environmental changes seem to have a significant effect on S. aurita growth and reproduction, which endorses their high phenotypic plasticity. 相似文献