全文获取类型
收费全文 | 145篇 |
免费 | 2篇 |
出版年
2016年 | 2篇 |
2015年 | 3篇 |
2014年 | 2篇 |
2010年 | 2篇 |
2009年 | 2篇 |
2008年 | 2篇 |
2005年 | 2篇 |
2003年 | 2篇 |
2001年 | 3篇 |
2000年 | 2篇 |
1999年 | 2篇 |
1998年 | 4篇 |
1997年 | 2篇 |
1989年 | 2篇 |
1986年 | 2篇 |
1977年 | 2篇 |
1960年 | 4篇 |
1959年 | 2篇 |
1957年 | 2篇 |
1956年 | 1篇 |
1955年 | 1篇 |
1953年 | 3篇 |
1952年 | 1篇 |
1947年 | 2篇 |
1945年 | 1篇 |
1940年 | 2篇 |
1939年 | 1篇 |
1938年 | 4篇 |
1937年 | 2篇 |
1936年 | 9篇 |
1935年 | 5篇 |
1934年 | 2篇 |
1933年 | 8篇 |
1932年 | 9篇 |
1931年 | 9篇 |
1930年 | 2篇 |
1929年 | 7篇 |
1927年 | 1篇 |
1926年 | 1篇 |
1924年 | 2篇 |
1923年 | 3篇 |
1922年 | 1篇 |
1920年 | 2篇 |
1919年 | 1篇 |
1918年 | 3篇 |
1916年 | 1篇 |
1914年 | 1篇 |
1910年 | 2篇 |
1909年 | 1篇 |
1907年 | 1篇 |
排序方式: 共有147条查询结果,搜索用时 15 毫秒
1.
Hardies SC; Martin SL; Voliva CF; Hutchison CA d; Edgell MH 《Molecular biology and evolution》1986,3(2):109-125
2.
LC-NMR: a new tool to expedite the dereplication and identification of natural products 总被引:1,自引:0,他引:1
The rapid identification of known or undesirable compounds from natural products extracts — “dereplication” — is an important
step in an efficiently run natural products discovery program. Dereplication strategies use analytical techniques and database
searching to determine the identity of an active compound at the earliest possible stage in the discovery process. In the
past few years, advances in technology have allowed the development of tandem analytical techniques such as liquid chromatography
mass spectrometry (LC-MS), LC-MS-MS, liquid chromatography nuclear magnetic resonance (LC-NMR), and LC-NMR-MS. LC-NMR, despite
its lower sensitivity as compared to LC-MS, provides a powerful tool for rapid identification of known compounds and identification
of structure classes of novel compounds. LC-NMR is especially useful in instances where the data from LC-MS are incomplete
or do not allow confident identification of the active component of a sample. LC-NMR has been used to identify the marine
alkaloid aaptamine as the active component in an extract of the sponge Aaptos sp. This extract had been identified as an enzyme inhibitor by a high throughput screening (HTS) effort. Isolated aaptamine
exhibited an IC50=120 μM against this enzyme. Strategies for the identification of aaptamine and for the use of LC-NMR in a natural products
HTS program are discussed. Journal of Industrial Microbiology & Biotechnology (2000) 25, 342–345.
Received 30 March 2000/ Accepted in revised form 03 July 2000 相似文献
3.
4.
R Moriggi Jr HS Di Mauro SC Dias JM Matos MB Urtado NF Camar?o IV Sousa Neto DC Nascimento RA Tibana CO Assump??o J Prestes CB Urtado 《Biology of sport / Institute of Sport》2015,32(4):289-294
Low intensity resistance exercise (RE) with blood flow restriction (BFR) has gained attention in the literature due to the beneficial effects on functional and morphological variables, similar to those observed during traditional RE without BFR, while the effects of BFR on post-exercise hypotension remain unclear. The aim of the present study was to compare the blood pressure (BP) response of trained normotensive individuals to RE with and without BFR. In this cross-over randomized trial, eight male subjects (23.8 ± 4 years, 74 ± 3 kg, 174 ± 4 cm) completed two exercise protocols: traditional RE (3 x 10 repetitions at 70% one-repetition maximum [1-RM]) and low intensity RE (3 x 15 repetitions at 20% 1-RM) with BFR. Blood pressure measurements were performed after 15 min of seated rest (0), immediately after and 10 min, 20 min, 30 min, 40 min, 50 min and 60 min after the experimental sessions. Similar hypotensive effects for systolic BP (SBP) were observed for both protocols (P < 0.05) after exercise, with no differences between groups (P > 0.05) and no statistically significant difference for diastolic BP (P > 0.05). These results suggest that in normotensive trained individuals, both traditional RE and RE with BFR induce hypotension for SBP, which is important to prevent cardiovascular disturbances. 相似文献
5.
JY Xiong SC Li YX Sun XS Zhang ZZ Dong P Zhong XR Sun 《Biology of sport / Institute of Sport》2015,32(4):295-300
Increasing evidence suggests that physical activity could delay or attenuate the symptoms of Alzheimer''s disease (AD). But the underlying mechanisms are still not fully understood. To investigate the effect of long-term treadmill exercise on the spatial memory of AD mice and the possible role of β-amyloid, brain-derived neurotrophic factor (BDNF) and microglia in the effect, male APPswe/PS1dE9 AD mice aged 4 months were subjected to treadmill exercise for 5 months with 6 sessions per week and gradually increased load. A Morris water maze was used to evaluate the spatial memory. Expression levels of β-amyloid, BDNF and Iba-1 (a microglia marker) in brain tissue were detected by immunohistochemistry. Sedentary AD mice and wildtype C57BL/6J mice served as controls. The results showed that 5-month treadmill exercise significantly decreased the escape latencies (P < 0.01 on the 4th day) and improved the spatial memory of the AD mice in the water maze test. Meanwhile, treadmill exercise significantly increased the number of BDNF-positive cells and decreased the ratios of activated microglia in both the cerebral cortex and the hippocampus. However, treadmill exercise did not significantly alleviate the accumulation of β-amyloid in either the cerebral cortex or the hippocampus of the AD mice (P > 0.05). The study suggested that long-term treadmill exercise could improve the spatial memory of the male APPswe/PS1dE9 AD mice. The increase in BDNF-positive cells and decrease in activated microglia might underpin the beneficial effect. 相似文献
6.
7.
8.
EO Ogueji CD Nwani SC Iheanacho CE Mbah CO Okeke A Yaji 《African Journal of Aquatic Science》2018,43(3):293-303
Indiscriminate discharge of pharmaceutical waste into the aquatic ecosystem may pose serious health challenges to aquatic biota. The effect of acute exposure to ibuprofen was evaluated using changes in behaviour and haematological parameters under static bio-assay method in Clarias gariepinus. Test specimens were exposed to acute concentrations of ibuprofen (0.28, 0.33, 0.38, 0.43 and 0.48 mg l?1) for 24, 48, 72 and 96 h durations respectively. Behavioural and phenotypic changes were observed in surviving fish. There were significant (p < 0.05) concentration and duration-dependent increases in erythrocyte (RBC), haemoglobin (Hb), pack cell volume (PCV) and leukocytes (WBC) in treated fish compared to the control. Insignificant decreases (p > 0.05) in mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCHC) were observed in treated fish compared to the control. Ibuprofen elicited dose and duration- dependent decrease in neutrophil counts with the decreases being significant (p < 0.05) in the higher doses of 0.43 and 0.48 mg l?1. Ibuprofen did not elicit any significant changes in monocytes, basophils and eosinophils. Changes observed in this study showed that ibuprofen negatively affected the health of the fish and we recommend that discharge of ibuprofen into the aquatic environment should be monitored and controlled. 相似文献
9.
Context-dependent memory: colour versus odour 总被引:2,自引:1,他引:1
An olfactory stimulus and a visual stimulus were employed in a context-
dependent memory study using a prose passage as the to-be-remembered item.
Ninety-five university students (aged 17-35 years) learned the passage of
prose in the presence of one of the stimuli and were then asked to recall
the passage with the original context either reinstated or not reinstated.
The results revealed a significant context-dependent memory effect for the
olfactory cue but not for the visual cue. They demonstrate support for the
effectiveness of odours as context cues and it is suggested that
context-dependent memory processes may underlie the formation and retrieval
of odour-evoked autobiographical memories.
相似文献
10.