排序方式: 共有2条查询结果,搜索用时 156 毫秒
1
1.
Aurora Arrúe Ricardo Dávila Mercedes Zumárraga Nieves Basterreche Miguel A. González-Torres Biotza Goienetxea Maria I. Zamalloa Juan B. Anguiano José Guimón 《Neurochemical research》2010,35(2):247-253
We have determined the plasma (p) concentration of gamma-aminobutyric acid (GABA) and the dopamine metabolite homovanillic
acid (HVA), and the pHVA/pGABA ratio in schizophrenic and bipolar patients. The research was undertaken in a geographic area
with an ethnically homogeneous population. The HVA plasma concentrations were significantly elevated in the schizophrenic
patients compared to the bipolar patients. The levels of pGABA was significantly lower in the two groups of patients compared
to the control group, while the pHVA/pGABA ratio was significantly greater in the both groups of patients compared to the
controls. As the levels of pHVA and pGABA are partially under genetic control it is better to compare their concentrations
within an homogeneous population. The values of the ratio pHVA/pGABA are compatible with the idea of an abnormal dopamine-GABA
interaction in schizophrenic and bipolar patients. The pHVA/pGABA ratio may be a good peripheral marker in psychiatric research. 相似文献
2.
Mercedes Zumárraga Ricardo Dávila Nieves Basterreche Aurora Arrue Biotza Goienetxea María I. Zamalloa Leire Erkoreka Sonia Bustamante Lucía Inchausti Miguel A. González-Torres José Guimón 《Neurochemistry international》2010,56(6-7):774-779
Metabolites of dopamine and norepinephrine measured in the plasma have long been associated with symptomatic severity and response to treatment in schizophrenic, bipolar and other psychiatric patients. Plasma concentrations of catecholamine metabolites are genetically regulated. The genes encoding enzymes that are involved in the synthesis and degradation of these monoamines are candidate targets for this genetic regulation. We have studied the relationship between the Val158Met polymorphism in catechol O-methyltransferase gene, variable tandem repeat polymorphisms in the monoamine oxidase A gene promoter, and plasma concentrations of 3-methoxy-4-hydroxyphenylglycol, 3,4-dihydroxyphenylacetic acid and homovanillic acid in healthy control subjects as well as in untreated schizophrenic and bipolar patients. We found that the Val158Met substitution in catechol O-methyltransferase gene influences the plasma concentrations of homovanillic and 3,4-dihydroxyphenylacetic acids. Although higher concentrations of plasma homovanillic acid were found in the high-activity ValVal genotype, this mutation did not affect the plasma concentration of 3-methoxy-4-hydroxyphenylglycol. 3,4-dihydroxyphenylacetic acid concentrations were higher in the low-activity MetMet genotype. Interestingly, plasma values 3-methoxy-4-hydroxyphenylglycol were greater in schizophrenic patients and in bipolar patients than in healthy controls. Our results are compatible with the previously reported effect of the Val158Met polymorphism on catechol O-methyltransferase enzymatic activity. Thus, our results suggest that this polymorphism, alone or associated with other polymorphisms, could have an important role in the genetic control of monoamine concentration and its metabolites. 相似文献
1