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Polymorphism of STR Loci of the Y Chromosome in Three Populations of Eastern Slavs from Belarus,Russia, and Ukraine 总被引:2,自引:0,他引:2
Kravchenko S. A. Slominsky P. A. Bets L. A. Stepanova A. V. Mikulich A. I. Limborska S. A. Livshits L. A. 《Russian Journal of Genetics》2002,38(1):80-86
Allelic polymorphism of five microsatellite loci of the human Y chromosome (DYS19, DYS390, DYS391, DYS392, and DYS393) was analyzed in samples of male populations from Ukraine, Russia, and Belarus (152 subjects in total). The allelic diversity indices (D
g) were determined for all loci; they varied from 0.23 to 0.72. The mean values of this parameter in the Ukrainian, Russian, and Belarussian populations were 0.45, 0.47, and 0.52, respectively. A total of 53 different haplotypes were found in 152 subjects from three populations. The most frequent haplotype was found in 14.5% of the subjects, whereas 35 haplotypes (23%) were each found in only one person. The haplotypic diversity index (D
hp) was 0.94. The genetic distances between the populations studied and some populations of Western and Central Europe were estimated. These data were used to construct a phylogram (tree) of genetic similarity between the populations, which demonstrated that the three Eastern Slavic populations are genetically close to one another and remote from Western European populations. 相似文献
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The anticancer drug doxorubicin penetrates into Langmuir monolayers containing phosphoinositides. Upon binding of doxorubicin to phosphoinositide-containing SUV, its fluorescence is self-quenched due to self-association. As compared to other anionic phospholipids, as much as 2- to 3-fold larger effects were obtained with PIP and PIP2, in mixtures of these lipids with DOPC. Doxorubicin competes efficiently with the non-penetrating antibiotic neomycin for binding to PIP2. According to its penetration, specific binding of doxorubicin was half-maximal at 5-15 microM. It is likely that also in biological membranes doxorubicin binds specifically to PIP and PIP2. 相似文献
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V Bets L 《Journal of PHYSIOLOGICAL ANTHROPOLOGY and Applied Human Science》2005,24(4):451-457
In a sample of 53 groups of adult males the regularity of spatial variability of hormonal concentrations (testosterone, estradiol, E/T index) was determined. The range of normal biochemical variations of sex hormones in different ethnic-geographical groups was revealed. The hormonal status of different ethnic groups was compared from the point of view of adaptation. The research results present new information on biological individuality and the factors defining it. The hormonal activity optimum depends on ecological factors and serves as a basis for the ecological monitoring of human health. 相似文献
4.
Kravchenko SA Slominskiĭ PA Bets LA Stepanova AV Mikulich AI Limborskaia SA Livshits LA 《Genetika》2002,38(1):97-104
Allelic polymorphism of five microsatellite loci of the human Y chromosome (DYS19, DYS390, DYS391, DYS392, and DYS393) was analyzed in samples of male populations from Ukraine, Russia, and Belarus (152 subjects in total). The allelic diversity indices (Dg) were determined for all loci; they varied from 0.23 to 0.72. The mean values of this parameter in the Ukrainian, Russian, and Belarussian populations were 0.45, 0.47, and 0.52, respectively. A total of 53 different haplotypes were found in 152 subjects from three populations. The most frequent haplotype was found in 14.5% of the subjects, whereas 35 haplotypes (23%) were each found in only one person. The haplotypic diversity index (Dhp) was 0.94. The genetic distances between the populations studied and some populations of Western and Central Europe were estimated. These data were used to construct a phylogram (tree) of genetic similarity between the populations, which demonstrated that the three Eastern Slavic populations are genetically close to one another and remote from Western European populations. 相似文献
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L V Bets A O Bukhanovski? I V Golubeva A S Andreev L M Baburin N K Shul'gina 《Nauchnye doklady vysshe? shkoly. Biologicheskie nauki》1992,(9):54-65
A complex constitutional-endocrinological investigation of persons of both sexes with clinical diagnosis of transsexualism (TS) has been held. On the basis of original data some peculiarities of somato- and cerebrotypes of transsexuals have been revealed, the formation of these peculiarities is significantly connected with the action of sexual hormones. A disturbance in ratio of male and female sexual hormones in the direction of predominance of the hormones corresponding to the patient's sexual autoidentification despite their biological sex has been marked. It gives possibility to consider that TS pathogenesis is undoubtedly connected with inborn pathology of hormonal homeostasis. The results of multi-disciplinary approach to study of TS are being discussed. An assumption about the role of disturbance in the system of "hormones-brain" in the TS origin is given. 相似文献
6.
Bets Victoria D. Achasova Kseniya M. Borisova Mariya A. Kozhevnikova Elena N. Litvinova Ekaterina A. 《Biochemistry. Biokhimii?a》2022,87(4):301-318
Biochemistry (Moscow) - Many factors underlie the development of inflammatory bowel disease (IBD) in humans. In particular, imbalance of microbiota and thinning of the mucosal layer in the large... 相似文献
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