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1.
Larvae and nymphs of the tick Ixodes ricinus L. display similar reactions to analogs of the insect juvenile hormones (methoprene and pyriproxyfen), which induce at both stages juvenalization of the Haller's sense organ regenerates. Similar effects were also described for retinoic acid. Unlike juvenoids, retinoic acid can affect not only regeneration, but also normal development of the Haller's organ and cause changes corresponding to so-called regenerative induction. Amputation of the leg and treatment with retinoic acid do not affect the duration of larval or nymphal development, while juvenoids somewhat accelerate their development. 相似文献
2.
A study of bacterial surface oligosaccharides were investigated among
different strains of Neisseria gonorrhoeae to correlate structural features
essential for binding to the MAb 2C7. This epitope is widely expressed and
conserved in gonococcal isolates, characteristics essential to an effective
candidate vaccine antigen. Sample lipooligosaccharides (LOS), was prepared
by a modification of the hot phenol-water method from which de-O-acetylated
LOS and oligosaccharide (OS) components were analyzed by ES-MS-CID-MS and
ES-MSnin a triple quadrupole and an ion trap mass spectrometer,
respectively. Previously documented natural heterogeneity was apparent from
both LOS and OS preparations which was admixed with fragments induced by
hydrazine and mild acid treatment. Natural heterogeneity was limited to
phosphorylation and antenni extensions to the alpha-chain. Mild acid
hydrolysis to release OS also hydrolyzed the beta(1-->6) glycosidic
linkage of lipid A. OS structures were determined by collisional and
resonance excitation combined with MS and multistep MSn which provided
sequence information from both neutral loss, and nonreducing terminal
fragments. A comparison of OS structures, with earlier knowledge of MAb
binding, enzyme treatment, and partial acid hydrolysis indicates a generic
overlapping domain for 2C7 binding. Reoccurring structural features include
a Hepalpha(1-->3)Hepbeta(1-->5)KDO trisaccharide core branched on the
nonreducing terminus (Hep-2) with an alpha(1-->2) linked GlcNAc
(gamma-chain), and an alpha-linked lactose (beta-chain) residue. From the
central heptose (Hep-1), a beta(1-->4) linked lactose (alpha-chain),
moiety is required although extensions to this residue appear unnecessary.
相似文献
3.
Belozerov VN 《Ontogenez》2004,35(3):213-219
The results of experiments on regeneration of the Haller's sensory organ in the metastriate ixodid tick Haemaphysalis longicornis Neumann in the presence of the juvenoid methoprene and retinoic acid and of studies of its structural changes by SEM confirmed the similarity of prostriate and metastriate ixodids as concerns the juvenalizing effect of the above morphogens on regenerative processes during nymphal-imaginal metamorphosis. However, the metastriate ticks (Haemaphysalis and earlier studied Hyalomma) are well behind the prostriate ticks (Ixodes) as concerns the extent of changes induced by juvenoids and retinoids in the sensillar sets of Haller's organ regenerates. 相似文献
4.
Extrinsic control of developmental diapause in nymphs of prostriate ticks of the subgenus Ixodes sensu stricto (Ixodes ricinus and Ixodes persulcatus from Eurasia and Ixodes scapularis from North America) appears to be based on a complex two-step photoperiodic reaction of a short-day/long-day type. Diapause
control in the subgenus Afrixodes (the South African tick Ixodes rubicundus) appears to be based on a simple long-day reaction. The option between non-diapause development and diapausing arrest in
engorged nymphs is determined by both pre- and post-feeding photoperiodic regimes. Consequently diapausing arrest in engorged
nymphs of Ixodes sensu stricto can be induced either by a short-day (after their engorgement) or by a long-day regime (in unfed nymphs), while active, non-diapause
development is possible only when the short-day pre-feeding regime is followed by a long-day post-feeding regime. The photoperiodic
response in I. (Afrixodes) rubicundus nymphs seems to be of the long-day type both before and after feeding. Consequently this non-diapause development is enabled
by a long-day regime, while diapause is induced by a short-day regime of exposure. Nevertheless, there are some indications
that the control of nymphal diapause in the latter species is also of a complex nature.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
5.
Belozerov VN 《Ontogenez》2003,34(1):50-60
Larvae and nymphae of the tick Ixodes ricinus L. display similar reactions to analogs of the insect juvenile hormones (methopren and pyriproxyfen), which induce at both stages juvenalization of the Haller's sense organ regenerates. Similar effects were also described for retinoic acid. Unlike juvenoids, retinoic acid can affect not only regeneration, but also normal development of the Haller's organ and cause changes corresponding to so-called regenerative induction. Amputation of the leg and treatment with retinoic acid do not affect the duration of larval or nymphal development, while juvenoids somewhat accelerate their development. 相似文献
6.
Vladimir E. Belozerov Srdjana Ratkovic Helen McNeill Arthur J. Hilliker John C. McDermott 《Molecular and cellular biology》2014,34(3):474-484
Several recent studies suggest that systemic aging in metazoans is differentially affected by functional decline in specific tissues, such as skeletal muscle. In Drosophila, longevity appears to be tightly linked to myoproteostasis, and the formation of misfolded protein aggregates is a hallmark of senescence in aging muscle. Similarly, defective myoproteostasis is described as an important contributor to the pathology of several age-related degenerative muscle diseases in humans, e.g., inclusion body myositis. p38 mitogen-activated protein kinase (MAPK) plays a central role in a conserved signaling pathway activated by a variety of stressful stimuli. Aging p38 MAPK mutant flies display accelerated motor function decline, concomitant with an enhanced accumulation of detergent-insoluble protein aggregates in thoracic muscles. Chemical genetic experiments suggest that p38-mediated regulation of myoproteostasis is not limited to the control of reactive oxygen species production or the protein degradation pathways but also involves upstream turnover pathways, e.g., translation. Using affinity purification and mass spectrometry, we identified Rack1 as a novel substrate of p38 MAPK in aging muscle and showed that the genetic interaction between p38b and Rack1 controls muscle aggregate formation, locomotor function, and longevity. Biochemical analyses of Rack1 in aging and stressed muscle suggest a model whereby p38 MAPK signaling causes a redistribution of Rack1 between a ribosome-bound pool and a putative translational repressor complex. 相似文献
7.
8.
V. N. Belozerov 《Entomological Review》2009,89(2):127-136
The paper resumes consideration of the problem posed by the Russian ecologist A.M. Emme (1953) on the need for a comparative study of diapause and quiescence (a non-diapause type of dormancy) in insects and other arthropods. The problem has recently become important due to the scarcity of eco-physiological studies of non-diapause dormancy, whose role in life cycle regulation remains unclear, and to the fact that most attention is now paid to diapause (as the leading adaptation in the control of seasonal development of arthropods). Analysis of data available for insects and acariform mites revealed the prospects of a comprehensive study of non-diapause forms of dormancy known presently (the common stage-independent quiescence, modified stage-specific quiescence, and post-diapause quiescence). The combination of post-diapause quiescence and diapause proper, revealed in many recent insects and acariform mites (mainly Prostigmata), may correspond to the initial ancestral state of dormancy in arthropods, representing a universal adaptation to both predictable and unpredictable environmental changes. This hypothesis gives a reasonable explanation of the possible dual nature of winter dormancy in oribatid mites (in contrast to the existing contradictory interpretations of their hibernal dormancy as only quiescence or only diapause). 相似文献
9.
L S Zingerman G S Topchiian I E Galankina G E Belozerov 《Vestnik rentgenologii i radiologii》1989,(1):19-24
Hemorrhagic myocardial infarction (HMI) has certain angiographic features that make it possible to diagnose it during the patient's life. HMI angiographic criteria are hypervascularization of an infarction zone in the late arterial phase, an intense contrast of an infarction zone in the parenchymal phase, extravasation of a contrast medium in an infarction zone in the venous phase of coronarography lasting for a long time, and slow discharge of a contrast medium from the distal vascular channel of an infarction zone. HMI characteristic features require thorough phase-by-phase angiographic investigation of the coronary arteries in all MI patients, especially in young ones and those after intracoronary thrombolytic therapy. The detected morphological spasm of microcirculatory vessels and veins disturbing the blood outflow from an infarction zone, noticeable hemorrhages in its interstice prove to be the morphological substantiation of HMI angiographic signs. 相似文献
10.
Belozerov A. G. Berezovsky Yu. M. Zherdev A. A. Korolev I. A. Pushkarev A. V. Agafonkina I. V. Tsiganov D. I. 《Biophysics》2018,63(2):268-273
Biophysics - A differential scanning calorimetry study of the specific isobaric heat capacity, phase-transition enthalpy, moisture content, and cryoscopic temperature for samples of benign and... 相似文献