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Bechr Hamrita Hela Ben Nasr Sallouha Gabbouj Noureddine Bouaouina Lotfi Chouchane Karim Chahed 《Molecular biology reports》2011,38(3):1637-1643
Apolipoprotein A1 (ApoA1) is the major apoprotein constituent of high-density lipoprotein that can play important roles in
tumor invasion and metastasis. In the current report, we evaluated the role of the functional ApoA1 polymorphisms (−75 G/A
and +83 C/T) as genetic markers for breast cancer susceptibility and prognosis. We used the polymerase chain reaction and
restriction enzyme digestion (RFLP-PCR) to characterize the variations of the ApoA1 gene in 295 unrelated Tunisian patients
with breast carcinoma and 197 healthy control subjects. No association was found between the +83 C/T genetic variation in
ApoA1 gene and the risk of breast cancer occurrence. The presence of the (+83) T allele appeared however to be associated
with an increased risk of lymph node metastasis occurrence (OR = 2.94; P = 0.01). Furthermore, a positive association was found between ApoA1 −75 A allele carriers and breast cancer risk (OR = 1.57;
P = 0.02). Regarding prognostic indicators, a significant association was found between ApoA1 (−75) A allele carriers and the
premenopausal status of breast cancer patients (OR = 1.73; P = 0.03). Additionally, the presence of the −75 A allele was correlated with the oestrogen receptor status among premenopausal
women (OR = 2.45; P = 0.02). This is the first report on the studies of ApoA1 single nucleotide polymorphisms (SNPs) in breast carcinomas. Our
data suggest that these genetic variations of ApoA1 may represent a marker for the increased risk of breast cancer. 相似文献
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Hassine Ikbel Hadj Gharbi Jawhar Hamrita Bechr Almalki Mohammed A. Rodríguez José Francisco Ben M’hadheb Manel 《Molecular biology reports》2020,47(4):2835-2843
Molecular Biology Reports - Coxsackievirus B4 (CV-B4) is suspected to be an environmental factor that has the intrinsic capacity to damage the pancreatic beta cells and therefore causes insulitis... 相似文献
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