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1.
T. A. Larkina A. L. Sazanova K. A. Fomichev O. Y. Barkova A. A. Sazanov T. Malewski K. Jaszczak 《Russian Journal of Genetics》2011,47(8):1012-1015
The quantitative traits of mass and percentage of abdominal fat in chicken and various types of obesity in mammals are homologous
and functionally similar. Therefore, the genes involved in obesity development in humans and laboratory rodents as well as
those responsible for pig lard thickness could be involved in abdominal fat deposition in broilers. Expression of candidate
genes FABP1, FABP2, FABP3, HMGA1, MC4R, PPARG, PPARGC1A, POMC and PTPN1 was studied in fat, liver, colon, muscle, pituitary gland, and brain in chicken (broilers) using real-time PCR. Significant
difference in the HMGA1 gene expression in the liver of broiler chicken with high (3.5 ± 0.18%) and low (1.9 ± 0.56%) abdominal fat concentration
has been revealed. The expression of this gene was been shown to correlate with the amount (0.7, P ≤ 0.01) and mass (0.7, P ≤ 0.01) of abdominal fat. The PPARG gene expression in liver in the same chicken subsets was also significantly different. Correlation coefficients of the gene
expression with the abdominal fat amount and mass were respectively 0.55 (P ≤ 0.05) and 0.57 (P ≤ 0.01). Based on these results, we suggest that the HMGA1 and PPARG genes are involved in abdominal fat deposition. The search for single nucleotide polymorphisms (SNPs) in the HMGA and PPARG regulatory regions could facilitate identifying genetic markers for broiler breeding according to the mass and percentage
of abdominal fat. 相似文献
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The association of SNP2-1 with egg quality traits in domestic chickens was analyzed. SNP2-1 alleles were significantly associated with the thickness of eggshells in chickens of the UK-72 line. The substitution of the SNP2-1 allele T for the C allele had an effect of 35 ± 15 μm, which corresponds to one standard deviation. For this trait, the effect of the T allele was dominant. SNP2-1 was also associated with other traits, including shell weight, egg-laying capacity in 60-week-old chickens (line UK-72), and egg weight in 60-week-old chickens (line cross CD). Thus, the QTL marked with SNP2-1 has a pleiotropic effect that depends on the chicken strain. Candidate genes located on chromosome 4 in close vicinity of SNP2-1 are discussed. 相似文献
3.
E N Barkova L N Shatilovich E A Kashuba 《Biulleten' eksperimental'no? biologii i meditsiny》1992,113(3):306-308
In Wistar rats, the seasonal variability of acrophase position, mesor value and circadian rhythm amplitudes of total leukocyte count, as well as of percentage and absolute lymphocyte count was revealed. The leukocyte count and absolute lymphocyte content were found highest in spring, while eosinophils--in autumn, neutrophils and monocytes--in winter. 相似文献
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I. Yu. Blagoveschensky A. L. Sazanova V. A. Stekol’nikova K. A. Fomichev O. Yu. Barkova M. N. Romanov A. A. Sazanov 《Russian Journal of Genetics》2011,47(3):272-278
To study pseudoautosomal and bordering regions in the avian Z and W chromosomes, we used seven BAC clones from genomic libraries
as DNA probes of fragments of different gametologs of the ATP5A1 gene located close to the proximal border of the pseudoautosomal region (PAR) of sex chromosomes of domestic chicken and
Japanese quail. Localization of BAC clones TAM31-b100C09, TAM31-b99N01, TAM31-b27P16, and TAM31-b95L18 in the short arm of
Z chromosomes of domestic chicken and Japanese quail (region Zp23-p22) and localization of the BAC clones CHORI-261-CH46G16,
CHORI-261-CH33F10, and CHORI-261-CH64F22 on W chromosomes of these species and in the short arm of Z chromosomes (region Zp23-p22)
were determined by fluorescence in situ hybridization with the use of W-specific probes. The difference in the localization
of the BAC clones on the Z and W chromosomes is probably explained by divergence of the nucleotide sequences of different
sex chromosomes located beyond the pseudoautosomal region. 相似文献
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G A Cherniaev T I Barkova I B Sorokina S N Ananchenko 《Biokhimii?a (Moscow, Russia)》1987,52(2):225-231
The relative affinities of estrogen-receptor complexes for rabbit uterine nuclei were measured, using a newly developed technique. The low ligand specificity of this interaction was established. 相似文献
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G A Cherniaev T I Barkova I B Sorokina S N Ananchenko 《Biokhimii?a (Moscow, Russia)》1987,52(1):102-109
The values of relative translocation of structural and steric analogs of estradiol in rabbit uterine homogenates were determined. The differences between the ligand specificity of translocation and that of the cytosol receptor was established. 相似文献
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