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Peter B. Sampson Christine Picard Sean Handerson Teresa E. McGrath Megan Domagala Andrew Leeson Vladimir Romanov Donald E. Awrey Dhushy Thambipillai Elias Bardouniotis Nachum Kaplan Judd M. Berman Henry W. Pauls 《Bioorganic & medicinal chemistry letters》2009,19(18):5355-5358
Spiropiperidine naphthyridinone inhibitors of Staphylococcus aureus and Escherichia coli FabI have been prepared. Compounds 14a and 14c were identified as having sub-nanomolar E. coli FabI activity and are among the most potent FabI inhibitors yet described. The structural model of 14a bound to E. coli FabI is shown. 相似文献
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The ability of non-tuberculous mycobacteria to form biofilms may allow for their increased resistance to currently used biocides
in medical and industrial settings. This study examines the biofilm growth of Mycobacterium fortuitum and Mycobacterium marinum, using the MBEC™ assay system, and compares the susceptibility of planktonic and biofilm cells to commercially available
biocides. With scanning electron microscopy, both M. fortuitum and M. marinum form biofilms that are morphologically distinct. Biocide susceptibility testing suggested that M. fortuitum biofilms displayed increased resistance over their planktonic state. This is contrasted with M. marinum biofilms, which were generally as or more susceptible over their planktonic state.
Received: 15 February 2002 / Accepted: 28 March 2002 相似文献
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The ability of non-tuberculous mycobacteria to form biofilms may allow for their increased resistance to currently used biocides in medical and industrial settings. This study examines the biofilm growth of Mycobacterium fortuitum and Mycobacterium marinum, using the MBEC trade mark assay system, and compares the susceptibility of planktonic and biofilm cells to commercially available biocides. With scanning electron microscopy, both M. fortuitum and M. marinum form biofilms that are morphologically distinct. Biocide susceptibility testing suggested that M. fortuitum biofilms displayed increased resistance over their planktonic state. This is contrasted with M. marinum biofilms, which were generally as or more susceptible over their planktonic state. 相似文献
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Jailall Ramnauth Mathew D. Surman Peter B. Sampson Bryan Forrest Jeff Wilson Emily Freeman David D. Manning Fernando Martin Andras Toro Megan Domagala Donald E. Awrey Elias Bardouniotis Nachum Kaplan Judd Berman Henry W. Pauls 《Bioorganic & medicinal chemistry letters》2009,19(18):5359-5362
In the search for new antibacterial agents, the enzyme FabI has been identified as an attractive target. Employing a structure guided approach, the previously reported ene-amide series of FabI inhibitors were expanded to include 2,3,4,5-tetrahydro-1H-pyrido[2,3-b and e][1,4]diazepines. These novel series incorporate additional H-bonding functions and can be more water soluble than their naphthyridinone progenitors; diazepine 16c is shown to be efficacious in a mouse infection model. 相似文献
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Characterization of biofilm growth and biocide susceptibility testing of Mycobacterium phlei using the MBEC assay system 总被引:2,自引:0,他引:2
The importance of non-tuberculosis mycobacterial biofilm species in medicine, industry and the environment has recently gained attention. Our objectives were to characterize biofilm growth of Mycobacterium phlei M4, as a model of rapidly growing mycobacteria using the minimal biofilm eradication concentration (MBEC) and to compare biocide susceptibility of planktonic and biofilm organisms. Scanning electron microscopy was also carried out to observe biofilm morphology. With the exception of Sporicidin and Virkon the minimum bactericidal concentration values for all biocides tested were lower than the MBEC values. The MBEC assay system was seen to produce multiple and reproducible biofilms of M. phlei and to be a useful tool for susceptibility studies. 相似文献
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