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Kudryavtseva N. N. Filipenko M. L. Bakshtanovskaya I. V. Avgustinovich D. F. Alekseenko O. V. Beilina A. G. 《Russian Journal of Genetics》2004,40(6):590-604
The role of genetic and environmental factors as well as brain neurochemistry in regulating aggressive and submissive behaviors in animals are considered. We present a review of data on changes in brain monoaminergic activity (synthesis, catabolism, receptors) and on the expression of monoaminergic genes under repeated daily agonistic confrontations in male mice. A repeated experience of aggression was shown to result in the total activation of the dopaminergic systems and the inhibition of the serotonergic one. This was accompanied by a decrease in the mRNA level of the cathecol-O-methyltransferase gene in the midbrain and an increase of the mRNA level of the dopamine transporter and tyrosine hydroxylase genes in the ventral tegmental area of aggressive male mice. Repeated experience of social defeats produced dynamic changes in the serotonergic system of some brain areas and an increase of the mRNA level of the serotonin transporter and monoamine oxidase A genes in the midbrain raphe nuclei. Theoretical and methodological possibilities of the proposed ethological approach for studying molecular mechanisms of agonistic behavior are discussed in the context of the fundamental problem of investigating the ways of regulation from behavior to gene. 相似文献
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The ability to develop the catatonic-like state (reflex immobility reaction - RIR) due to stimulation of the skin at the scruff was investigated in mice of two strains — C57BL/6J and CBA/Lac. The total time of immobility and number of paroxysms during test were measured. It has been shown that the number of paroxysms was significantly fewer and the total time of immobility was significantly longer in CBA/Lac strain than in C57BL/6J. In each strain group housed animals as well as submissive ones with successive experience of defeats demonstrated a more expressed immobility than individually housed or aggressive males with successive experience of victories, respectively. Changing the social status in aggressive animals as a consequence of confrontation with aggressive males resulted in the increased immobility in CBA/Lac but not in C57BL/6J mice. The results suggest that the experience of defeat in submissive males is connected with increased ability to develop RIR. 相似文献
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