Protein-nitrogen metabolism in the liver of rats intraperitoneally administered carminomycin]

It was found in the experiments with rats that in response to carminomycin administration in a single LD50 and the therapeutic doses during the treatment course the intracellular fond of the amino acids in the liver tissue increased, the autolytic processes activated, the activity of the transamination enzymes, histidine and ammonia lyases increased. The level of the residual nitrogen increased mainly at the expense of increased ammonia production and urea levels. These changes were more pronounced when the antibiotic was administered in LD50. Independent of the administration multiplicity and the antibiotic dosage they were of reversible nature and mainly disappeared by the end of the observation.     

Erratum to: Characteristics of Vacuolar Inclusions in Coelastrella rubescens Namsu R1 Green Microalgae Cells in Low- and High-Intensity Light

Russian Journal of Plant Physiology - Under the growth experiment, the effect of zinc deficiency in the substrate on a number of growth of barley parameters, the state of the photosynthetic...     

Studies of the impurity pellet ablation in the high-temperature plasma of magnetic confinement devices

The ablation of impurity pellets in tokamak and stellarator plasmas is investigated. Different mechanisms for shielding the heat fluxes from the surrounding plasma to the pellet surface are discussed. A model for impurity pellet ablation is developed that can account for both neutral and electrostatic shielding. It is shown that the experimental values of the impurity pellet ablation rate are well described by the neutral gas shielding model over a wide range of plasma temperatures and densities. Taking into account the electrostatic shielding leads to worse agreement between the predictions of the model and the experimental data; this result still remains unclear. Scaling laws are obtained that allow one to estimate the local ablation rate of impurity pellets made of various materials over a wide range of plasma parameters in the neutral gas shielding model.     

Microbiocenosis of stomach in children with chronic gastritis

Qualitative and quantitative composition of gastric microflora has been studied in 30 children with chronic gastritis. Bacteriological study of gastric biopsies and parietal mucus in 10 children with chronic gastritis not associated with Helicobacter pylori more frequently revealed conditionally pathogenic bacteria--Escherichia coli, Staphylococcus aureus, Streptococcus viridans, S. pyogenes (group A), Peptostreptococcus anaerobius, P. prevotii and their associations. In 20 studied patients with H.pylori-associated chronic gastritis composition of local microflora was less diverse--conditionally pathogenic, lacto- and bifidobacteria often were absent. Study showed that eradication of H. pylori led to appearance of conditionally pathogenic bacteria in stomach microflora, which were frequently isolated in associations. Not effective treatment was associated with disappearance of lacto- and bifidobacteria and frequent isolation of Candida albicans.     

Molecular characterization of Streptococcus pneumoniae,particularly serotype19A/ST320, which emerged in Krasnoyarsk,Russia

Streptococcus pneumoniae , a common human pathogen, colonizes the nasopharynx and causes diseases including acute otitis media (AOM). Herein, pneumococcal serotype distributions in children before and after PCV7 vaccination and in patients with pneumococcal disease in Siberian Russia (Krasnoyarsk) are reported. Analyses included antimicrobial susceptibility testing, sequence typing (ST), pulsed field gel electrophoresis, virulence‐related surface protein gene (VSG) typing with novel primers and structural analysis by scanning electron microscopy. In healthy children (HC) prior to administration of PCV7, drug‐susceptible serotype23F/ST1500 was a major pneumococcal genotype. In the PCV7 trial, multidrug‐resistant serotype19A/ST320 emerged in vaccinees after PCV7, exhibiting a PCV7‐induced serotype replacement. Multidrug‐resistant serotype19A/ST320 was evident in patients with AOM. Community‐acquired pneumonia (CAP) isolates showed genetic similarities to the AOM (ST320) genotype, constituting a common non‐invasive AOM–CAP group. In contrast, meningitis isolates were more divergent. Overall, 25 ST types were identified; five (20%) of which were Krasnoyarsk‐native. Regarding VSGs, PI‐1 (rlrA /rrgB ), PI‐2 (pitA /B ), psrP and cbpA were present at 54.3%, 38.6%, 48.6%, and 95.7%, respectively, with two major VSG content types, PI‐1^?/PI‐2^?/psrP ⁺/cbpA ⁺ and PI‐1⁺/PI‐2⁺/psrP ^‐/cbpA ⁺, being found for HC and non‐invasive diseases, respectively. A major clone of serotype19A/ST320 (PI‐1⁺/PI‐2⁺) produced the longest pneumococcal wire (pilus) structures in colonies. ST1016 (PI‐1^?/PI‐2^?) in HC had HEp‐2 cell‐adherent pili. These results suggest that serotype19A/ST320 and related genotypes, with the VSG content type PI‐1⁺/PI‐2⁺/psrP ^?/cbpA ⁺, emerged in vaccinees after PCV7 in Siberia, accompanying diseases in non‐vaccinated children, and that some genotypes (serotypes19A/ST320 and 18/ST1016) produced novel pneumococcal structures, predicting their roles in colony formation and adherence.

     

Uncharged Gemini-Amphiphiles as Components of Cationic Liposomes for Delivery of Nucleic Acids

Russian Journal of Bioorganic Chemistry - New uncharged gemini-amphiphiles have been synthesized. A series of cationic liposomes based on the polycationic amphiphile...     

Studies of the structure of C pellet ablation clouds in W7-AS

The structure of the ablation clouds surrounding carbon pellets injected into the ECR-heated Wendelstein 7-AS plasma has been studied. Snapshot and integrated photographs obtained in the spectral ranges containing the CII (720 ± 5 nm and 723 ± 1 nm) and CIII (770 ± 5 nm) spectral lines were analyzed over a wide range of the bulk plasma parameters. It is found that the cloud luminosity profile along the magnetic field is exponential with either one or two characteristic decay lengths of about a few millimeters and a few centimeters. The smaller length corresponds to the zone closer to the pellet. There is good agreement between the characteristic decay lengths deduced from snapshot and integrated photographs. The characteristic decay lengths were obtained along the entire pellet trajectory and were found to change weakly in the central region and to grow at the plasma periphery (generally, in inverse proportion to the plasma electron density). In the central region, the characteristic decay lengths are about a few millimeters and 1 cm. They depend weakly on the bulk plasma temperature and decrease with increasing bulk plasma density. These lengths agree fairly well with estimates of the ionization length of carbon ions into the C²⁺, C³⁺, and C⁴⁺ charge states, respectively, assuming that ionization is provided by the hot electrons of the bulk plasma and that the cloud expands with the ion-acoustic velocity at a temperature of ～1 eV. The results obtained prove that the cloud structure in the vicinity of the pellet is mainly determined by the bulk plasma electrons.