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排序方式: 共有440条查询结果,搜索用时 15 毫秒
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Keven D. Juaire Karine Lapouge Matthias M.M. Becker Irina Kotova Michelle Michelhans Raphael Carapito Klemens Wild Seiamak Bahram Irmgard Sinning 《Structure (London, England : 1993)》2021,29(1):15-28.e7
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Bahrami Armina Alagheband Bandehpour Mojgan Khalesi Bahman Kazemi Bahram 《International journal of peptide research and therapeutics》2020,26(1):389-403
International Journal of Peptide Research and Therapeutics - Infections with HCV, HBV and poliovirus are still considered to be substantial global health burdens. Vaccination is one of the most... 相似文献
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Mahboudi Somayeh Moosavi-Nasab Marzieh Kazemi Bahram Rahimpour Azam Eskandari Mohammad Hadi Mohammadian Omid Shams Forough 《Molecular biology reports》2021,48(5):4405-4412
Molecular Biology Reports - Monoclonal antibodies (mAbs) are widely employed as invaluable therapeutics for a vast number of human disorders. Several approaches have been introduced for the... 相似文献
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Dastmalchi Narges Safaralizadeh Reza Hosseinpourfeizi Mohammad Ali Baradaran Behzad Khojasteh Seyed Mahdi Banan 《Molecular biology reports》2021,48(2):1345-1357
Molecular Biology Reports - Combination therapy has been considered as a potential method to overcome the BC chemoresistance. MicroRNAs (miRs) have been suggested as a therapeutic factor in the... 相似文献
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Aghajani Marjan Mokhtarzadeh Ahad Aghebati-Maleki Leili Mansoori Behzad Mohammadi Ali Safaei Sahar Asadzadeh Zahra Hajiasgharzadeh Khalil Khaze Shahgoli Vahid Baradaran Behzad 《Molecular biology reports》2020,47(5):3691-3703
Molecular Biology Reports - One of the major barriers in cancer therapy is the resistance to conventional therapies and cancer stem cells (CSCs) are among the main causes of this problem. CD133 as... 相似文献
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Zohreh Jahanafrooz Jaffar Mosafer Morteza Akbari Mahmoud Hashemzaei Ahad Mokhtarzadeh Behzad Baradaran 《Journal of cellular physiology》2020,235(5):4153-4166
Despite many advances and optimization in colon cancer treatment, tumor recurrence and metastases make the development of new therapies necessary. Colon cancer stem cells (CCSCs) are considered as the main triggering factor of cancer progression, recurrence, and metastasis. CCSCs as a result of accumulated genetic and epigenetic alterations and also complex interconnection with the tumor microenvironment (TME) can evolve and convert to full malignant cells. Mounting evidence suggests that in cancer therapy both CCSCs and non-CCSCs in TME have to be regarded to break through the limitation of current therapies. In this regard, stem cell capabilities of some non-CCSCs may arise inside the TME condition. Therefore, a deep knowledge of regulatory mechanisms, heterogeneity, specific markers, and signaling pathways of CCSCs and their interconnection with TME components is needed to improve the treatment of colorectal cancer and the patient's life quality. In this review, we address current different targeted therapeutic options that target cell surface markers and signaling pathways of CCSCs and other components of TME. Current challenges and future perspectives of colon cancer personalized therapy are also provided here. Taken together, based on the deep understanding of biology of CCSCs and using three-dimensional culture technologies, it can be possible to reach successful colon cancer eradication and improvise combination targeted therapies against CCSCs and TME. 相似文献
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One of the most fundamental concepts of evolutionary dynamics is the “fixation” probability, i.e. the probability that a mutant spreads through the whole population. Most natural communities are geographically structured into habitats exchanging individuals among each other and can be modeled by an evolutionary graph (EG), where directed links weight the probability for the offspring of one individual to replace another individual in the community. EGs have recently spurred huge interest, as it has been shown that some topology can amplify or suppress the effect of beneficial mutations. Very few exact analytical results however are known for EGs. In this article we show that the use of a new technique, the fixed point of probability generating function, allows us to compute the exact fixation probability for a large subset of bithermal graphs. We also show by numerical simulations that the computed solution holds for all bithermal graphs. Moreover, the analytical solution allows us to clarify the opposing consequences of birth–death versus death–birth processes as amplifier or suppressor of beneficial mutations for the same bithermal topology. 相似文献