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KIRAN KAUR KIM EMMETT PETER P. McCANN ALBERT SJOERDSMA BUDDY ULLMAN 《The Journal of eukaryotic microbiology》1986,33(4):518-521
ABSTRACT. Alpha-difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase, has been demonstrated to be an effective agent against a variety of parasitic protozoa but not against Leishmania spp. In this report, we show that Leishmania donovani promastigotes in continuous culture are sensitive to the growth inhibitory and cytotoxic effects of DFMO. Incubation of the promastigotes with DFMO obliterates intracellular putrescine pools and depletes spermidine concentrations, which correlates with the onset of growth inhibition. The effects of DFMO on the growth and the intracellular polyamine pools can be reversed completely by the addition of 10 μM putrescine to the culture medium. These results suggest that the treatment of leishmaniasis may be amenable to chemotherapeutic manipulation by DFMO. 相似文献
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R. B. KIMSEY P. G. MARKHAM M. G. KINSEY D. E. ULLMAN D. L. McLEAN 《The Annals of applied biology》1986,109(3):657-660
Single stranded materials including individual silk fibres and human hair were gold plated with a sputter coater and used in place of gold wire electrodes in electronic systems for monitoring insect feeding behaviour. 相似文献
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The botanical product RD-Repelin® was highly repellent to pea aphids at concentrations of 1%, 4% or 10%. Repellency occurred prior to leaf contact by aphids at all three concentrations. RD-Repelin® delayed symptom expression of zucchini yellow mosaic virus (ZYMV) in 81% of plants treated with 1% concentration, although virus transmission was not prevented. The effects of RD-Repelin® on aphid settling behaviour, symptom expression and potential for pest management are discussed. 相似文献
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