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Developmental programming: State‐of‐the‐science and future directions–Summary from a Pennington Biomedical symposium 下载免费PDF全文
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Monique M. P. D. Heijmans Yasmijn A. M. van der Knaap Milena Holmgren Juul Limpens 《Global Change Biology》2013,19(7):2240-2250
Peatlands store approximately 30% of global soil carbon, most in moss‐dominated bogs. Future climatic changes, such as changes in precipitation patterns and warming, are expected to affect peat bog vegetation composition and thereby its long‐term carbon sequestration capacity. Theoretical work suggests that an episode of rapid environmental change is more likely to trigger transitions to alternative ecosystem states than a gradual, but equally large, change in conditions. We used a dynamic vegetation model to explore the impacts of drought events and increased temperature on vegetation composition of temperate peat bogs. We analyzed the consequences of six patterns of summer drought events combined with five temperature scenarios to test whether an open peat bog dominated by moss (Sphagnum) could shift to a tree‐dominated state. Unexpectedly, neither a gradual decrease in the amount of summer precipitation nor the occurrence of a number of extremely dry summers in a row could shift the moss‐dominated peat bog permanently into a tree‐dominated peat bog. The increase in tree biomass during drought events was unable to trigger positive feedbacks that keep the ecosystem in a tree‐dominated state after a return to previous ‘normal’ rainfall conditions. In contrast, temperature increases from 1 °C onward already shifted peat bogs into tree‐dominated ecosystems. In our simulations, drought events facilitated tree establishment, but temperature determined how much tree biomass could develop. Our results suggest that under current climatic conditions, peat bog vegetation is rather resilient to drought events, but very sensitive to temperature increases, indicating that future warming is likely to trigger persistent vegetation shifts. 相似文献
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Bingxi Li Monique M. P. D. Heijmans Frank Berendse Daan Blok Trofim Maximov Ute Sass-Klaassen 《Polar Biology》2016,39(7):1245-1255
It is widely believed that deciduous tundra-shrub dominance is increasing in the pan-Arctic region, mainly due to rising temperature. We sampled dwarf birch (Betula nana L.) at a northeastern Siberian tundra site and used dendrochronological methods to explore the relationship between climatic variables and local shrub dominance. We found that establishment of shrub ramets was positively related to summer precipitation, which implies that the current high dominance of B. nana at our study site could be related to high summer precipitation in the period from 1960 to 1990. The results confirmed that early summer temperature is most influential to annual growth rates of B. nana. In addition, summer precipitation stimulated shrub growth in years with warm summers, suggesting that B. nana growth may be co-limited by summer moisture supply. The dual controlling role of temperature and summer precipitation on B. nana growth and establishment is important to predict future climate-driven vegetation dynamics in the Arctic tundra. 相似文献
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Qihua Tan Morten Frost Bastiaan T Heijmans Jacob von Bornemann Hjelmborg Elmar W Tobi Kaare Christensen Lene Christiansen 《BMC genomics》2014,15(1)
Background
A low birth weight has been extensively related to poor adult health outcomes. Birth weight can be seen as a proxy for environmental conditions during prenatal development. Identical twin pairs discordant for birth weight provide an extraordinary model for investigating the association between birth weight and adult life health while controlling for not only genetics but also postnatal rearing environment. We performed an epigenome-wide profiling on blood samples from 150 pairs of adult monozygotic twins discordant for birth weight to look for molecular evidence of epigenetic signatures in association with birth weight discordance.Results
Our association analysis revealed no CpG site with genome-wide statistical significance (FDR < 0.05) for either qualitative (larger or smaller) or quantitative discordance in birth weight. Even with selected samples of extremely birth weight discordant twin pairs, no significant site was found except for 3 CpGs that displayed age-dependent intra-pair differential methylation with FDRs 0.014 (cg26856578, p = 3.42e-08), 0.0256 (cg15122603, p = 1.25e-07) and 0.0258 (cg16636641, p = 2.05e-07). Among the three sites, intra-pair differential methylation increased with age for cg26856578 but decreased with age for cg15122603 and cg16636641. There was no genome-wide statistical significance for sex-dependent effects on intra-pair differential methylation in either the whole samples or the extremely discordant twins.Conclusions
Genome-wide DNA methylation profiling did not reveal epigenetic signatures of birth weight discordance although some sites displayed age-dependent intra-pair differential methylation in the extremely discordant twin pairs.Electronic supplementary material
The online version of this article (doi:10.1186/1471-2164-15-1062) contains supplementary material, which is available to authorized users. 相似文献6.
Angela Breeuwer Monique M. P. D. Heijmans Maurits Gleichman Bjorn J. M. Robroek Frank Berendse 《Plant Ecology》2009,204(1):97-111
To predict the role of ombrotrophic bogs as carbon sinks in the future, it is crucial to understand how Sphagnum vegetation in bogs will respond to global change. We performed a greenhouse experiment to study the effects of two temperature
treatments (17.5 and 21.7°C) and two N addition treatments (0 and 4 g N m−2 year−1) on the growth of four Sphagnum species from three geographically interspersed regions: S. fuscum, S. balticum (northern and central Sweden), S. magellanicum and S. cuspidatum (southern Sweden). We studied the growth and cover change in four combinations of these Sphagnum species during two growing seasons. Sphagnum height increment and production were affected negatively by high temperature and high N addition. However, the northern species
were more affected by temperature, while the southern species were more affected by N addition. High temperature depressed
the cover of the ‘wet’ species, S. balticum and S. cuspidatum. Nitrogen concentrations increased with high N addition. N:P and N:K ratios indicated P-limited growth in all treatments
and co-limitation of P and K in the high N treatments. In the second year of the experiment, several containers suffered from
a severe fungal infection, particularly affecting the ‘wet’ species and the high N treatment. Our findings suggest that global
change can have negative consequences for the production of Sphagnum species in bogs, with important implications for the carbon sequestration in these ecosystems. 相似文献
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H. J. A. M. Heijmans 《Journal of mathematical biology》1984,21(2):115-143
In this paper, we study an analytical model describing predatory behaviour. It is assumed that the parameter describing the predator's behaviour is its satiation. Using semigroup methods and compactness arguments we prove that a stable satiation distribution is reached if t. Furthermore, using a Trotter-Kato theorem we justify the transition to the much simpler problem that is obtained if the prey biomass tends to zero. 相似文献
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Roderick C. Slieker Matthias S. Roost Liesbeth van Iperen H. Eka D. Suchiman Elmar W. Tobi Fran?oise Carlotti Eelco J. P. de Koning P. Eline Slagboom Bastiaan T. Heijmans Susana M. Chuva de Sousa Lopes 《PLoS genetics》2015,11(10)
Remodelling the methylome is a hallmark of mammalian development and cell differentiation. However, current knowledge of DNA methylation dynamics in human tissue specification and organ development largely stems from the extrapolation of studies in vitro and animal models. Here, we report on the DNA methylation landscape using the 450k array of four human tissues (amnion, muscle, adrenal and pancreas) during the first and second trimester of gestation (9,18 and 22 weeks). We show that a tissue-specific signature, constituted by tissue-specific hypomethylated CpG sites, was already present at 9 weeks of gestation (W9). Furthermore, we report large-scale remodelling of DNA methylation from W9 to W22. Gain of DNA methylation preferentially occurred near genes involved in general developmental processes, whereas loss of DNA methylation mapped to genes with tissue-specific functions. Dynamic DNA methylation was associated with enhancers, but not promoters. Comparison of our data with external fetal adrenal, brain and liver revealed striking similarities in the trajectory of DNA methylation during fetal development. The analysis of gene expression data indicated that dynamic DNA methylation was associated with the progressive repression of developmental programs and the activation of genes involved in tissue-specific processes. The DNA methylation landscape of human fetal development provides insight into regulatory elements that guide tissue specification and lead to organ functionality. 相似文献
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Talens RP Christensen K Putter H Willemsen G Christiansen L Kremer D Suchiman HE Slagboom PE Boomsma DI Heijmans BT 《Aging cell》2012,11(4):694-703
The accumulation of epigenetic changes was proposed to contribute to the age-related increase in the risk of most common diseases. In this study on 230 monozygotic twin pairs (MZ pairs), aged 18-89 years, we investigated the occurrence of epigenetic changes over the adult lifespan. Using mass spectrometry, we investigated variation in global (LINE1) DNA methylation and in DNA methylation at INS, KCNQ1OT1, IGF2, GNASAS, ABCA1, LEP, and CRH, candidate loci for common diseases. Except for KCNQ1OT1, interindividual variation in locus-specific DNA methylation was larger in old individuals than in young individuals, ranging from 1.2-fold larger at ABCA1 (P = 0.010) to 1.6-fold larger at INS (P = 3.7 × 10(-07) ). Similarly, there was more within-MZ-pair discordance in old as compared with young MZ pairs, except for GNASAS, ranging from an 8% increase in discordance each decade at CRH (P = 8.9 × 10(-06) ) to a 16% increase each decade at LEP (P = 2.0 × 10(-08) ). Still, old MZ pairs with strikingly similar DNA methylation were also observed at these loci. After 10-year follow-up in elderly twins, the variation in DNA methylation showed a similar pattern of change as observed cross-sectionally. The age-related increase in methylation variation was generally attributable to unique environmental factors, except for CRH, for which familial factors may play a more important role. In conclusion, sustained epigenetic differences arise from early adulthood to old age and contribute to an increasing discordance of MZ twins during aging. 相似文献