全文获取类型
收费全文 | 538286篇 |
免费 | 53704篇 |
国内免费 | 5252篇 |
出版年
2021年 | 6724篇 |
2019年 | 5437篇 |
2018年 | 12299篇 |
2017年 | 11260篇 |
2016年 | 11649篇 |
2015年 | 11165篇 |
2014年 | 12944篇 |
2013年 | 16491篇 |
2012年 | 20850篇 |
2011年 | 24681篇 |
2010年 | 17200篇 |
2009年 | 16022篇 |
2008年 | 19502篇 |
2007年 | 20908篇 |
2006年 | 13120篇 |
2005年 | 13240篇 |
2004年 | 12432篇 |
2003年 | 12066篇 |
2002年 | 11658篇 |
2001年 | 23406篇 |
2000年 | 23460篇 |
1999年 | 18543篇 |
1998年 | 5999篇 |
1997年 | 6292篇 |
1996年 | 5935篇 |
1995年 | 5610篇 |
1994年 | 5448篇 |
1993年 | 5155篇 |
1992年 | 14503篇 |
1991年 | 13795篇 |
1990年 | 13122篇 |
1989年 | 12832篇 |
1988年 | 11844篇 |
1987年 | 10963篇 |
1986年 | 9873篇 |
1985年 | 9903篇 |
1984年 | 7968篇 |
1983年 | 7013篇 |
1982年 | 5371篇 |
1981年 | 4637篇 |
1980年 | 4370篇 |
1979年 | 7740篇 |
1978年 | 5806篇 |
1977年 | 5396篇 |
1976年 | 4924篇 |
1975年 | 5380篇 |
1974年 | 5757篇 |
1973年 | 5827篇 |
1972年 | 5869篇 |
1971年 | 5428篇 |
排序方式: 共有10000条查询结果,搜索用时 203 毫秒
1.
2.
3.
4.
Plant Molecular Biology - 相似文献
5.
6.
7.
Suzanne Camus Sergio Menéndez Kenneth Fernandes Nelly Kua Geng Liu Dimitris P. Xirodimas David P. Lane Jean-Christophe Bourdon 《Cell cycle (Georgetown, Tex.)》2012,11(8):1646-1655
The discovery that the single p53 gene encodes several different p53 protein isoforms has initiated a flurry of research into the function and regulation of these novel p53 proteins. Full-length p53 protein level is primarily regulated by the E3-ligase Mdm2, which promotes p53 ubiquitination and degradation. Here, we report that all of the novel p53 isoforms are ubiquitinated and degraded to varying degrees in an Mdm2-dependent and -independent manner, and that high-risk human papillomavirus can degrade some but not all of the novel isoforms, demonstrating that full-length p53 and the p53 isoforms are differentially regulated. In addition, we provide the first evidence that Mdm2 promotes the NEDDylation of p53β. Altogether, our data indicates that Mdm2 can distinguish between the p53 isoforms and modify them differently. 相似文献
8.
9.
10.
The effect of the alkyl side chain of the ubiquinone molecule on the electron-transfer activity of ubiquinone in mitochondrial succinate-cytochrome c reductase is studied by using synthetic ubiquinone derivatives that possess the basic ubiquinone structure of 2,3-dimethoxy-5-methyl-1,4-benzoquinone with different alkyl side chains at the 6-position. The alkyl side chains vary in chain length, degree of saturation, and location of double bonds. When a ubiquinone derivative is used as an electron acceptor for succinate-ubiquinone reductase, an alkyl side chain of six carbons is needed to obtain the maximum activity. However, when it serves as an electron donor for ubiquinol-cytochrome c reductase or as a mediator in succinate-cytochrome c reductase, an alkyl side chain of 10 carbons gives maximal efficiency. Introduction of one or two isolated double bonds into the alkyl side chain of the ubiquinone molecule has little effect on electron-transfer activity. However, a conjugated double bond system in the alkyl side chain drastically reduces electron-transfer efficiency. The effect of the conjugated double bond system on the electron-transferring efficiency of ubiquinone depends on its location in the alkyl side chain. When location is far from the benzoquinone ring, the effect is minimal. These observations together with the results obtained from photoaffinity-labeling studies lead us to conclude that flexibility in the portion of the alkyl side chain immediately adjacent to the benzoquinone ring is required for the electron-transfer activity of ubiquinone. 相似文献