Exon-intron structure of genes in complete fungal genomes

Computer analysis of genes was performed for lower fungi Aspergillus fumigatus, Candida glabrata, Cryptococcus neoformans, Debaryomyces hansenii, Encephalitozoon cuniculi, Eremothecium gossypii, Kluyveromyces lactis, Magnaporthe grisea, Neurospora crassa, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Ustilago maydis, and Yarrowia lipolytica. The content of genes with an exon-intron structure in their genomes varied from 0.7 to 97.0%. The exon-intron structure substantially changes with an increasing portion of intron-containing genes. Gene size and total exon length proved to linearly depend on the intron number in the A. fumigatus, C. neoformans, M. grisea, N. crassa, S. pombe, and U. maydis genomes.     

Intron and exon length variation in <Emphasis Type="Italic">Arabidopsis</Emphasis>, rice,nematode, and human

As determined by computer sequence analysis, the average exon length in Arabidopsis thaliana, Oryza sativa, Caenorhabditis elegans, and Homo sapiens genes decreases with an increasing number of introns. In A. thaliana and O. sativa, variations in intron and exon lengths with an increasing number of introns are highly correlated. Linear correlation is observed between the total exon length and the number of introns, while the gene length increases in proportion to the number of introns. In human, the average intron and gene lengths depended on the gene density in DNA.     

The Interaction of miRNA-5p and miRNA-3p with the mRNAs of Orthologous Genes

Molecular Biology - miRNAs regulate the expression of many genes and are involved in the development of diseases. We studied miRNAs that interact partly or fully complementarily with the 5'UTR,...