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Wijayanti Nastiti Gazali Faris Muhammad Supriyati Endah Hakim Mohamad Saifudin Arguni Eggi Daniwijaya Marselinus Edwin Widyanto Nuryastuti Titik Nuhamunada Matin Nabilla Rahma Haryana Sofia Mubarika Wibawa Tri 《International microbiology》2022,25(3):531-540
International Microbiology - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new virus responsible for the COVID-19 pandemic. The emergence of the new SARS-CoV-2 has been... 相似文献
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Warsito Tantowijoyo Stephanie K. Tanamas Indah Nurhayati Sigit Setyawan Nida Budiwati Iva Fitriana Inggrid Ernesia Dwi Satria Wardana Endah Supriyati Eggi Arguni Yeti Meitika Equatori Prabowo Bekti Andari Benjamin R. Green Lauren Hodgson Edwige Rancs Peter A. Ryan Scott L. ONeill Katherine L. Anders M. Ridwan Ansari Citra Indriani Riris Andono Ahmad Adi Utarini Cameron P. Simmons 《PLoS neglected tropical diseases》2022,16(4)
The Applying Wolbachia to Eliminate Dengue (AWED) trial was a parallel cluster randomised trial that demonstrated Wolbachia (wMel) introgression into Ae. aegypti populations reduced dengue incidence. In this predefined substudy, we compared between treatment arms, the relative abundance of Ae. aegypti and Ae. albopictus before, during and after wMel-introgression. Between March 2015 and March 2020, 60,084 BG trap collections yielded 478,254 Ae. aegypti and 17,623 Ae. albopictus. Between treatment arms there was no measurable difference in Ae. aegypti relative abundance before or after wMel-deployments, with a count ratio of 0.96 (95% CI 0.76, 1.21) and 1.00 (95% CI 0.85, 1.17) respectively. More Ae. aegypti were caught per trap per week in the wMel-intervention arm compared to the control arm during wMel deployments (count ratio 1.23 (95% CI 1.03, 1.46)). Between treatment arms there was no measurable difference in the Ae. albopictus population size before, during or after wMel-deployment (overall count ratio 1.10 (95% CI 0.89, 1.35)). We also compared insecticide resistance phenotypes of Ae. aegypti in the first and second years after wMel-deployments. Ae. aegypti field populations from wMel-treated and untreated arms were similarly resistant to malathion (0.8%), permethrin (1.25%) and cyfluthrin (0.15%) in year 1 and year 2 of the trial. In summary, we found no between-arm differences in the relative abundance of Ae. aegypti or Ae. albopictus prior to or after wMel introgression, and no between-arm difference in Ae. aegypti insecticide resistance phenotypes. These data suggest neither Aedes abundance, nor insecticide resistance, confounded the epidemiological outcomes of the AWED trial. 相似文献
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H L Yeap G Ra?i? N M Endersby-Harshman S F Lee E Arguni H Le Nguyen A A Hoffmann 《Heredity》2016,116(3):265-276
Wolbachia is the most widespread endosymbiotic bacterium of insects and
other arthropods that can rapidly invade host populations. Deliberate releases of
Wolbachia into natural populations of the dengue fever mosquito,
Aedes aegypti, are used as a novel biocontrol strategy for dengue
suppression. Invasion of Wolbachia through the host population relies on
factors such as high fidelity of the endosymbiont transmission and limited
immigration of uninfected individuals, but these factors can be difficult to measure.
One way of acquiring relevant information is to consider mitochondrial DNA (mtDNA)
variation alongside Wolbachia in field-caught mosquitoes. Here we used
diagnostic mtDNA markers to differentiate infection-associated mtDNA haplotypes from
those of the uninfected mosquitoes at release sites. Unique haplotypes associated
with Wolbachia were found at locations outside Australia. We also performed
mathematical and qualitative analyses including modelling the expected dynamics of
the Wolbachia and mtDNA variants during and after a release. Our analyses
identified key features in haplotype frequency patterns to infer the presence of
imperfect maternal transmission of Wolbachia, presence of immigration and
possibly incomplete cytoplasmic incompatibility. We demonstrate that ongoing
screening of the mtDNA variants should provide information on maternal leakage and
immigration, particularly in releases outside Australia. As we demonstrate in a case
study, our models to track the Wolbachia dynamics can be successfully
applied to temporal studies in natural populations or Wolbachia release
programs, as long as there is co-occurring mtDNA variation that differentiates
infected and uninfected populations. 相似文献
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