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D Ricquier F Bouillaud P Toumelin G Mory R Bazin J Arch L Pénicaud 《The Journal of biological chemistry》1986,261(30):13905-13910
3.
Regulation of T cell apoptosis 总被引:3,自引:0,他引:3
4.
Yunjiao Wang Pawel Paszek Caroline A Horton Douglas B Kell Michael RH White David S Broomhead Mark R Muldoon 《BMC systems biology》2011,5(1):23
Background
Sustained stimulation with tumour necrosis factor alpha (TNF-alpha) induces substantial oscillations—observed at both the single cell and population levels—in the nuclear factor kappa B (NF-kappa B) system. Although the mechanism has not yet been elucidated fully, a core system has been identified consisting of a negative feedback loop involving NF-kappa B (RelA:p50 hetero-dimer) and its inhibitor I-kappa B-alpha. Many authors have suggested that this core oscillator should couple to other oscillatory pathways. 相似文献5.
Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids 总被引:1,自引:0,他引:1
Mohamed S. Zaibi Jacqueline O’Dowd Mohamed Bellahcene Alastair J.H. Brown Jonathan R.S. Arch 《FEBS letters》2010,584(11):2381-2386
GPR41 is reportedly expressed in murine adipose tissue and mediates short chain fatty acid (SCFA)-stimulated leptin secretion by activating Gαi. Here, we agree with a contradictory report in finding no expression of GPR41 in murine adipose tissue. Nevertheless, in the presence of adenosine deaminase to minimise Gαi signalling via the adenosine A1 receptor, SCFA stimulated leptin secretion by adipocytes from wild-type but not GPR41 knockout mice. Expression of GPR43 was reduced in GPR41 knockout mice. Acetate but not butyrate stimulated leptin secretion in wild-type mesenteric adipocytes, consistent with mediation of the response by GPR43 rather than GPR41. Pertussis toxin prevented stimulation of leptin secretion by propionate in epididymal adipocytes, implicating Gαi signalling mediated by GPR43 in SCFA-stimulated leptin secretion. 相似文献
6.
Ultrasonic signalling by a Bornean frog 总被引:2,自引:0,他引:2
Among anuran amphibians, only two species, Odorrana tormota and Huia cavitympanum, are known to possess recessed tympanic membranes. Odorrana tormota is the first non-mammalian vertebrate demonstrated to communicate with ultrasonic frequencies (above 20 kHz), and the frogs' sunken tympana are hypothesized to play a key role in their high-frequency hearing sensitivity. Here we present the first data on the vocalizations of H. cavitympanum. We found that this species emits extraordinarily high-frequency calls, a portion of which are comprised entirely of ultrasound. This represents the first documentation of an anuran species producing purely ultrasonic signals. In addition, the vocal repertoire of H. cavitympanum is highly variable in frequency modulation pattern and spectral composition. The frogs' use of vocal signals with a wide range of dominant frequencies may be a strategy to maximize acoustic energy transmission to both nearby and distant receivers. The convergence of these species' call characteristics should stimulate additional, phylogenetically based studies of other lower vertebrates to provide new insight into the mechanistic and evolutionary foundations of high-frequency hearing in all vertebrate forms. 相似文献
7.
Leptin receptor long-form signalling in a human liver cell line. 总被引:2,自引:0,他引:2
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A loss-of-function mutation in the endothelin-converting enzyme 1 (ECE-1) associated with Hirschsprung disease, cardiac defects, and autonomic dysfunction. 总被引:9,自引:0,他引:9
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9.
Previous methods for separation of overlapping data peaks include geometrical assessment and Fourier deconvolution. On the basis of inverse diffusion theory, we present new separation methods suitable for convenient programming and rapid calculation of Gaussian area contributions. Both continuum and discrete inverse diffusion models are described. Example computations are given for biological data: density gradient centrifugation, isoelectric focusing electrophoresis, and high-pressure liquid chromatography. 相似文献
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