排序方式: 共有3条查询结果,搜索用时 15 毫秒
1
1.
Antarianto Radiana D Mahmood Amer Giselvania Angela Asri Dewi Ayu AA Prima Gustinanda Jatmiko Pawitan Jeanne Adiwinata 《Journal of molecular histology》2022,53(4):611-621
Journal of Molecular Histology - End-stage liver disease (ESLD) is a term used clinically in reference to a group of liver diseases with liver transplantation as the choice of treatment. Due to the... 相似文献
2.
3.
Novi Silvia Hardiany Adrian Prasetya Karman Aisha Safa Putri Calista Budi Gittanaya Anindyanari Daniell Edward Rahardjo Puti Retasya Novira Rania Rifdah Taufiq Shofiyya Imtiyaz Radiana Dhewayani Antarianto 《Reports of Biochemistry & Molecular Biology》2022,11(2):190
Background:Oxidative stress is defined as the condition in which balance between the synthesis and detoxification of reactive oxygen species in cells is disrupted. This research explored the effects of intermittent and prolonged fasting on malondialdehyde (MDA), carbonyl, reduced glutathione (GSH), and specific activity of catalase as biomarkers for oxidative stress in hearts, brains, and kidneys of New Zealand White (NZW) rabbits.Methods:Fifteen NZW rabbits were divided into control, intermittent fasting (IF), and prolonged fasting (PF) groups. The controls were fed ad lib. IF and PF groups were fasted for 16 and 40 hours, respectively, followed by eight hours of non-fasting, for six days and were sacrificed on the 7th day. One hundred mg of heart, brain, and kidney tissues were homogenized in 1 ml of phosphate-buffered saline. MDA, carbonyl, GSH, and catalase were analyzed by spectrophotometry. Data were analyzed using One-way ANOVA and post hoc test.Results:In heart, MDA was significantly greater in the control than in the IF and PF groups. In brain, GSH was greater in the IF than in the PF and control groups. Also, in brain, catalase specific activity was significantly greater in the control than in the IF and PF groups. In kidney, catalase specific activity was significantly less in the PF than in the control group.Conclusion:The effect of fasting on oxidative stress in various organs showed various responses, however fasting reduced oxidative stress based on MDA and GSH levels in the heart and brain, respectively.Key Words: Fasting, Oxidative stress, Vital organs, Rabbit 相似文献
1