全文获取类型
收费全文 | 36504篇 |
免费 | 3261篇 |
国内免费 | 231篇 |
出版年
2023年 | 187篇 |
2022年 | 477篇 |
2021年 | 964篇 |
2020年 | 540篇 |
2019年 | 692篇 |
2018年 | 803篇 |
2017年 | 628篇 |
2016年 | 1134篇 |
2015年 | 1903篇 |
2014年 | 1993篇 |
2013年 | 2349篇 |
2012年 | 3014篇 |
2011年 | 3050篇 |
2010年 | 1872篇 |
2009年 | 1551篇 |
2008年 | 2262篇 |
2007年 | 2210篇 |
2006年 | 2172篇 |
2005年 | 1841篇 |
2004年 | 1878篇 |
2003年 | 1624篇 |
2002年 | 1566篇 |
2001年 | 381篇 |
2000年 | 308篇 |
1999年 | 361篇 |
1998年 | 338篇 |
1997年 | 257篇 |
1996年 | 235篇 |
1995年 | 203篇 |
1994年 | 192篇 |
1993年 | 184篇 |
1992年 | 180篇 |
1991年 | 214篇 |
1990年 | 149篇 |
1989年 | 149篇 |
1988年 | 139篇 |
1987年 | 121篇 |
1986年 | 128篇 |
1985年 | 144篇 |
1984年 | 135篇 |
1983年 | 123篇 |
1982年 | 134篇 |
1981年 | 130篇 |
1980年 | 102篇 |
1979年 | 91篇 |
1978年 | 68篇 |
1976年 | 64篇 |
1975年 | 67篇 |
1974年 | 68篇 |
1973年 | 65篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
3.
Andrew C Smith 《BMJ (Clinical research ed.)》1981,283(6306):1596-1597
4.
Denise Risch Nicholas J. Gales Jason Gedamke Lars Kindermann Douglas P. Nowacek Andrew J. Read Ursula Siebert Ilse C. Van Opzeeland Sofie M. Van Parijs Ari S. Friedlaender 《Biology letters》2014,10(4)
For decades, the bio-duck sound has been recorded in the Southern Ocean, but the animal producing it has remained a mystery. Heard mainly during austral winter in the Southern Ocean, this ubiquitous sound has been recorded in Antarctic waters and contemporaneously off the Australian west coast. Here, we present conclusive evidence that the bio-duck sound is produced by Antarctic minke whales (Balaenoptera bonaerensis). We analysed data from multi-sensor acoustic recording tags that included intense bio-duck sounds as well as singular downsweeps that have previously been attributed to this species. This finding allows the interpretation of a wealth of long-term acoustic recordings for this previously acoustically concealed species, which will improve our understanding of the distribution, abundance and behaviour of Antarctic minke whales. This is critical information for a species that inhabits a difficult to access sea-ice environment that is changing rapidly in some regions and has been the subject of contentious lethal sampling efforts and ongoing international legal action. 相似文献
5.
6.
Benjamin C. Blum Weiwei Lin Matthew L. Lawton Qian Liu Julian Kwan Isabella Turcinovic Ryan Hekman Pingzhao Hu Andrew Emili 《Molecular & cellular proteomics : MCP》2022,21(1):100189
Metabolism is recognized as an important driver of cancer progression and other complex diseases, but global metabolite profiling remains a challenge. Protein expression profiling is often a poor proxy since existing pathway enrichment models provide an incomplete mapping between the proteome and metabolism. To overcome these gaps, we introduce multiomic metabolic enrichment network analysis (MOMENTA), an integrative multiomic data analysis framework for more accurately deducing metabolic pathway changes from proteomics data alone in a gene set analysis context by leveraging protein interaction networks to extend annotated metabolic models. We apply MOMENTA to proteomic data from diverse cancer cell lines and human tumors to demonstrate its utility at revealing variation in metabolic pathway activity across cancer types, which we verify using independent metabolomics measurements. The novel metabolic networks we uncover in breast cancer and other tumors are linked to clinical outcomes, underscoring the pathophysiological relevance of the findings. 相似文献
7.
Andrew Leask 《Journal of cell communication and signaling》2010,4(1):71-72
Connective tissue growth factor (CTGF/CCN2) is overexpressed in diabetes. Diabetic rats possess myocardial and cardiomyocyte
hypertrophy. In a recent report, Wang and colleagues (Am J Physiol Cell Physiol. 2009 Jul 22. [Epub ahead of print]) show
that CCN2 directly mediates cardiomyocyte hypertrophy as well as that induced by high glucose and fatty acid. CCN2 acted via
the TrkA receptor. These data are the subject of this commentary, and emphasize that CCN2 may be an excellent target for therapy
in diabetes. 相似文献
8.
9.
Liquid–liquid phase separation (LLPS) of some IDPs/IDRs can lead to the formation of the membraneless organelles in vitro and in vivo, which are essential for many biological processes in the cell. Here we select three different IDR segments of chaperon Swc5 and develop a polymeric slab model at the residue-level. By performing the molecular dynamics simulations, LLPS can be observed at low temperatures even without charge interactions and disappear at high temperatures. Both the sequence length and the charge pattern of the Swc5 segments can influence the critical temperature of LLPS. The results suggest that the effects of the electrostatic interactions on the LLPS behaviors can change significantly with the ratios and distributions of the charged residues, especially the sequence charge decoration (SCD) values. In addition, three different forms of swc conformation can be distinguished on the phase diagram, which is different from the conventional behavior of the free IDP/IDR. Both the packed form (the condensed-phase) and the dispersed form (the dilute-phase) of swc chains are found to be coexisted when LLPS occurs. They change to the fully-spread form at high temperatures. These findings will be helpful for the investigation of the IDP/IDR ensemble behaviors as well as the fundamental mechanism of the LLPS process in bio-systems. 相似文献
10.
Andrew Bamji 《BMJ (Clinical research ed.)》1987,294(6574):772-773