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Debode Frédéric Marien Aline Ledoux Quentin Janssen Eric Ancion Cécile Berben Gilbert 《Transgenic research》2020,29(3):283-294
Transgenic Research - Numbers of ornamental transgenic fish are increasing, and some of them are illegally imported into Europe. The fish are modified to display different fluorescent colors under... 相似文献
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Elevated Plasma Soluble ST2 Is Associated with Heart Failure Symptoms and Outcome in Aortic Stenosis
Patrizio Lancellotti Raluca Dulgheru Julien Magne Christine Henri Laurence Servais Nassim Bouznad Arnaud Ancion Christophe Martinez Laurent Davin Caroline Le Goff Alain Nchimi Luc Piérard Cécile Oury 《PloS one》2015,10(9)
B-type natriuretic peptide (BNP) is often used as a complementary finding in the diagnostic work-up of patients with aortic stenosis (AS). Whether soluble ST2, a new biomarker of cardiac stretch, is associated with symptomatic status and outcome in asymptomatic AS is unknown. sST2 and BNP levels were measured in 86 patients (74±13 years; 59 asymptomatic, 69%) with AS (<1.5 cm2) and preserved left ventricular ejection fraction who were followed-up for 26±16 months. Both BNP and sST2 were associated with NYHA class but sST2 (>23 ng/mL, AUC = 0.68, p<0.01) was more accurate to identify asymptomatic patients or those who developed symptoms during follow-up. sST2 was independently related to left atrial index (p<0.0001) and aortic valve area (p = 0.004; model R2 = 0.32). A modest correlation was found with BNP (r = 0.4, p<0.01). During follow-up, 29 asymptomatic patients (34%) developed heart failure symptoms. With multivariable analysis, peak aortic jet velocity (HR = 2.7, p = 0.007) and sST2 level (HR = 1.04, p = 0.03) were independent predictors of cardiovascular events. In AS, sST2 levels could provide complementary information regarding symptomatic status, new onset heart failure symptoms and outcome. It might become a promising biomarker in these patients. 相似文献
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We evaluate the reliability of communities of bacteria and ciliated protozoa as indicators of freshwater ecological health.
Samples of epilithic biofilm were taken from 18 freshwater streams, impacted by varying types and degrees of catchment modification.
Communities of bacteria and ciliates were characterised using DNA fingerprinting techniques (automated ribosomal intergenic
spacer analysis and terminal restriction fragment length polymorphism, respectively) and macroinvertebrate data also obtained,
for comparison. Similar to the macroinvertebrates, the taxa richness of ciliate communities was reduced in more developed
stream catchments; significant differences in the evenness of ciliate communities were also detected. We could identify no
significant relationship between the richness of bacterial taxa and the percentage catchment development. However, a significant
trend was detected between bacterial community structure and the predominant catchment land use (rural vs. urban) using a
Bray–Curtis measure of similarity, a relationship not detected for the ciliate and macroinvertebrate communities. These findings
indicate that stream bacterial, ciliate and macroinvertebrate communities each respond differently to various catchment conditions
and highlight the potential of microbial communities to provide novel, alternative indicators of stream ecosystem health. 相似文献
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