全文获取类型
收费全文 | 158篇 |
免费 | 9篇 |
出版年
2020年 | 1篇 |
2018年 | 2篇 |
2016年 | 1篇 |
2015年 | 6篇 |
2014年 | 8篇 |
2013年 | 8篇 |
2012年 | 8篇 |
2011年 | 13篇 |
2010年 | 16篇 |
2009年 | 5篇 |
2008年 | 5篇 |
2007年 | 8篇 |
2006年 | 9篇 |
2005年 | 6篇 |
2004年 | 9篇 |
2003年 | 10篇 |
2002年 | 5篇 |
2001年 | 5篇 |
2000年 | 5篇 |
1999年 | 6篇 |
1998年 | 2篇 |
1997年 | 1篇 |
1995年 | 1篇 |
1994年 | 1篇 |
1993年 | 1篇 |
1992年 | 1篇 |
1989年 | 5篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1986年 | 2篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1982年 | 1篇 |
1980年 | 1篇 |
1979年 | 2篇 |
1975年 | 1篇 |
1973年 | 1篇 |
1972年 | 2篇 |
1971年 | 1篇 |
1967年 | 1篇 |
1965年 | 1篇 |
1960年 | 1篇 |
排序方式: 共有167条查询结果,搜索用时 15 毫秒
1.
Alvar W. Carlson 《Economic botany》1986,40(2):233-249
Ginseng has long been one of this country’s major botanical drugs in foreign trade. Once harvested only in the forests of the Eastern frontiers, it became a domesticated crop in the late 1800s and now is raised largely in northcentral Wisconsin. Growers there produce an estimated 90% of the cultivated ginseng in the United States. Most American ginseng has been consumed in the Orient, as is reflected in export records dating back to 1821. Over 95% of the nearly 21,000 metric tons (T) shipped in the period 1821–1983 went to the Far East. Hong Kong has served as the center for re-exporting ginseng to China and Southeast Asia. Ginseng has been used in Asia for many purposes, mostly as a curative agent. It has also gained increasing acceptance elsewhere in the world for its alleged value. 相似文献
2.
Absence of prostaglandins in semen of men with cystic fibrosis is an indication of the contribution of the seminal vesicles 总被引:1,自引:0,他引:1
E Bendvold C Gottlieb K Svanborg H Gilljam B Strandvik M Bygdeman P Eneroth 《Journal of reproduction and fertility》1986,78(1):311-314
Five men with cystic fibrosis delivered semen samples which were analysed for the content of the four main groups of prostaglandins (PGs). No PGs could be found in any of the specimens. The results of the present study provide further evidence that the seminal vesicles constitute the dominant site of production of PGs in human semen. 相似文献
3.
Maria S. Cordova Ruben Lisker Alvar Loria 《American journal of physical anthropology》1967,26(1):55-65
Blood samples from 1090 Mexican Indians belonging to the Chol, Chontal, Totonac, Huastec, Mixe, Mazatec, Zapotec, Mixtec, Chinantec, Nahua, Cora and Huichol linguistic groups, were obtained and examined in regard to the following blood group antigens: A, B. M, N, P, C, c, D, E, e, Fy(a), K and Di(a). The gene frequencies were similar to what has been described for other Amerindians; high values for O, M, CDe, cDE and Duffy; low to absent Kell and presence of Diego in variable amounts. The frequency of chromosomes CDE and cDe/cde was somewhat higher than usual and some of the tribes had relatively high frequencies of the A and B antigens. It was felt that variable degrees of non-Indian admixture was at least partially responsible for this situation. A previous study dealing with the distribution of abnormal hemoglobins and glucose-6-phosphate dehydrogenase deficiency in these same tribes, had strongly suggested the possibility of some Negro admixture in the Chontal, Nahua and Cora tribes. However, this was not specifically reflected in their blood group distribution. This served to emphasize the need of investigating as many markers as possible when trying to characterize a population. 相似文献
4.
Cirl C Wieser A Yadav M Duerr S Schubert S Fischer H Stappert D Wantia N Rodriguez N Wagner H Svanborg C Miethke T 《Nature medicine》2008,14(4):399-406
Pathogenic microbes have evolved sophisticated molecular strategies to subvert host defenses. Here we show that virulent bacteria interfere directly with Toll-like receptor (TLR) function by secreting inhibitory homologs of the Toll/interleukin-1 receptor (TIR) domain. Genes encoding TIR domain containing-proteins (Tcps) were identified in Escherichia coli CFT073 (TcpC) and Brucella melitensis (TcpB). We found that TcpC is common in the most virulent uropathogenic E. coli strains and promotes bacterial survival and kidney pathology in vivo. In silico analysis predicted significant tertiary structure homology to the TIR domain of human TLR1, and we show that the Tcps impede TLR signaling through the myeloid differentiation factor 88 (MyD88) adaptor protein, owing to direct binding of Tcps to MyD88. Tcps represent a new class of virulence factors that act by inhibiting TLR- and MyD88-specific signaling, thus suppressing innate immunity and increasing virulence. 相似文献
5.
Ann-Kathrine Granerus Rudolf Jagenburg Stig R?djer Alvar Svanborg 《BMJ (Clinical research ed.)》1971,4(5782):262-264
Oral and intravenous L-phenylalanine loading tests were performed in 13 Parkinsonian patients and in 12 control subjects matched for age and weight. The results showed a normal intestinal absorption and a normal elimination from plasma of phenylalanine in the Parkinsonian patients. 相似文献
6.
7.
Chappuis F Sundar S Hailu A Ghalib H Rijal S Peeling RW Alvar J Boelaert M 《Nature reviews. Microbiology》2007,5(11):873-882
Visceral leishmaniasis (VL) is a systemic protozoan disease that is transmitted by phlebotomine sandflies. Poor and neglected populations in East Africa and the Indian sub-continent are particularly affected. Early and accurate diagnosis and treatment remain key components of VL control. In addition to improved diagnostic tests, accurate and simple tests are needed to identify treatment failures. Miltefosine, paromomycin and liposomal amphotericin B are gradually replacing pentavalent antimonials and conventional amphotericin B as the preferred treatments in some regions, but in other areas these drugs are still being evaluated in both mono- and combination therapies. New diagnostic tools and new treatment strategies will only have an impact if they are made widely available to patients. 相似文献
8.
Hang L Haraoka M Agace WW Leffler H Burdick M Strieter R Svanborg C 《Journal of immunology (Baltimore, Md. : 1950)》1999,162(5):3037-3044
IL-8 is a major human neutrophil chemoattractant at mucosal infection sites. This study examined the C-X-C chemokine response to mucosal infection, and, specifically, the role of macrophage inflammatory protein (MIP)-2, one of the mouse IL-8 equivalents, for neutrophil-epithelial interactions. Following intravesical Escherichia coli infection, several C-X-C chemokines were secreted into the urine, but only MIP-2 concentrations correlated to neutrophil numbers. Tissue quantitation demonstrated that kidney MIP-2 production was triggered by infection, and immunohistochemistry identified the kidney epithelium as a main source of MIP-2. Treatment with anti-MIP-2 Ab reduced the urine neutrophil numbers, but the mice had normal tissue neutrophil levels. By immunohistochemistry, the neutrophils were found in aggregates under the pelvic epithelium, but in control mice the neutrophils crossed the urothelium into the urine. The results demonstrate that different chemokines direct neutrophil migration from the bloodstream to the lamina propria and across the epithelium and that MIP-2 serves the latter function. These findings suggest that neutrophils cross epithelial cell barriers in a highly regulated manner in response to chemokines elaborated at this site. This is yet another mechanism that defines the mucosal compartment and differentiates the local from the systemic host response. 相似文献
9.
Trucco A Polishchuk RS Martella O Di Pentima A Fusella A Di Giandomenico D San Pietro E Beznoussenko GV Polishchuk EV Baldassarre M Buccione R Geerts WJ Koster AJ Burger KN Mironov AA Luini A 《Nature cell biology》2004,6(11):1071-1081
The organization of secretory traffic remains unclear, mainly because of the complex structure and dynamics of the secretory pathway. We have thus studied a simplified system, a single synchronized traffic wave crossing an individual Golgi stack, using electron tomography. Endoplasmic-reticulum-to-Golgi carriers join the stack by fusing with cis cisternae and induce the formation of intercisternal tubules, through which they redistribute their contents throughout the stack. These tubules seem to be pervious to Golgi enzymes, whereas Golgi vesicles are depleted of both enzymes and cargo. Cargo then traverses the stack without leaving the cisternal lumen. When cargo exits the stack, intercisternal connections disappear. These findings provide a new view of secretory traffic that includes dynamic intercompartment continuities as key players. 相似文献
10.