全文获取类型
收费全文 | 152篇 |
免费 | 12篇 |
出版年
2023年 | 3篇 |
2022年 | 7篇 |
2021年 | 16篇 |
2020年 | 5篇 |
2019年 | 5篇 |
2018年 | 7篇 |
2017年 | 4篇 |
2016年 | 6篇 |
2015年 | 11篇 |
2014年 | 9篇 |
2013年 | 13篇 |
2012年 | 12篇 |
2011年 | 11篇 |
2010年 | 5篇 |
2009年 | 5篇 |
2008年 | 6篇 |
2007年 | 7篇 |
2006年 | 2篇 |
2005年 | 1篇 |
2004年 | 1篇 |
2003年 | 3篇 |
2002年 | 3篇 |
2001年 | 2篇 |
1992年 | 1篇 |
1990年 | 1篇 |
1988年 | 2篇 |
1984年 | 1篇 |
1973年 | 1篇 |
1970年 | 1篇 |
1962年 | 3篇 |
1961年 | 1篇 |
1957年 | 2篇 |
1956年 | 1篇 |
1955年 | 2篇 |
1953年 | 1篇 |
1950年 | 1篇 |
1920年 | 2篇 |
排序方式: 共有164条查询结果,搜索用时 125 毫秒
1.
2.
3.
Turner Alexandria Bond Danielle R. Vuong Quan V. Chalmers Anita Beckett Emma L. Weidenhofer Judith Scarlett Christopher J. 《Molecular biology reports》2020,47(3):2073-2084
Molecular Biology Reports - Treatment options for pancreatic cancer (PC) are severely limited due to late diagnosis, early metastasis and the inadequacy of chemotherapy and radiotherapy to combat... 相似文献
4.
Megan K. L. MacLeod Alexandria David Niyun Jin Laura Noges Jieru Wang John W. Kappler Philippa Marrack 《PloS one》2013,8(4)
Influenza virus poses a difficult challenge for protective immunity. This virus is adept at altering its surface proteins, the proteins that are the targets of neutralizing antibody. Consequently, each year a new vaccine must be developed to combat the current recirculating strains. A universal influenza vaccine that primes specific memory cells that recognise conserved parts of the virus could prove to be effective against both annual influenza variants and newly emergent potentially pandemic strains. Such a vaccine will have to contain a safe and effective adjuvant that can be used in individuals of all ages. We examine protection from viral challenge in mice vaccinated with the nucleoprotein from the PR8 strain of influenza A, a protein that is highly conserved across viral subtypes. Vaccination with nucleoprotein delivered with a universally used and safe adjuvant, composed of insoluble aluminium salts, provides protection against viruses that either express the same or an altered version of nucleoprotein. This protection correlated with the presence of nucleoprotein specific CD8 T cells in the lungs of infected animals at early time points after infection. In contrast, immunization with NP delivered with alum and the detoxified LPS adjuvant, monophosphoryl lipid A, provided some protection to the homologous viral strain but no protection against infection by influenza expressing a variant nucleoprotein. Together, these data point towards a vaccine solution for all influenza A subtypes. 相似文献
5.
6.
Dhimant Desai Matthew Lauver Alexandria Ostman Linda Cruz Kevin Ferguson Ge Jin Brianne Roper Daniel Brosius Aron Lukacher Shantu Amin Nick Buchkovich 《Bioorganic & medicinal chemistry》2019,27(9):1795-1803
Opportunistic viruses are a major problem for immunosuppressed individuals, particularly following organ or stem cell transplantation. Current treatments are non-existent or suffer from problems such as high toxicity or development of resistant strains. We previously published that a trafficking inhibitor that targets a host protein greatly reduces the replication of human cytomegalovirus. This inhibitor was also shown to be moderately effective against polyomaviruses, another family of opportunistic viruses. We have developed a panel of analogues for this inhibitor and have shown that these analogues maintain their high efficacy against HCMV, while substantially lowering the concentration required to inhibit polyomavirus replication. By targeting a host protein these compounds are able to inhibit the replication of two very different viruses. These observations open up the possibility of pan-viral inhibitors for immunosuppressed individuals that are effective against multiple, diverse opportunistic viruses. 相似文献
7.
8.
The response to centrally administered beta-endorphin has been characterized by decreasing sympathetic nervous activity and decreased cardiovascular tone. We investigated the effect of the central administration of both mu and kappa opioid receptor agonist and antagonists on cardiovascular responses. The administration of the mu agonist, DAMGO (0.2nmol) increased the mean arterial pressure (MAP) and stimulated iliac vasoconstriction while higher doses (2 and 20nmol) decreased MAP and stimulated iliac vasodilation. The administration of the kappa receptor agonist, Dynorphin decreased the MAP and stimulated superior mesenteric vasodilation. beta-Funaltrexamine reduced MAP and superior mesenteric vasodilation while nor-binaltorphimine increased MAP and iliac and superior mesenteric vasoconstriction. We conclude that mu receptor activation decrease or increase MAP depending on the mu agonist concentration. However, kappa receptor activation is consistently associated with a decrease in MAP. 相似文献
9.
10.