排序方式: 共有13条查询结果,搜索用时 31 毫秒
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Dmitrieva NA Molchan OK Komissarov AA Sokolov VB Aksinenko AIu Pushin AN Chekhlov AN Debabov VG 《Bioorganicheskaia khimiia》1998,24(12):920-925
5,5-Bis(hydroxymethyl)-2-oxo-[1-(2-trifluoromethyl)-3,3,3- trifluoropropionamido)-1-trifluoromethyl-2,2,2-trifluoroethyl- 1,3,2-dioxaphosphan (CA-423) is an in vitro inhibitor of the Escherichia coli uridine and thymidine phosphorylases. Unlike widely studied nucleoside analogues, this compound binds to the enzymes irreversibly. Its LD50 in mice was 40 mg/kg. Due to the involvement of pyrimidine phosphorylases in carcinogenesis and the relatively low toxicity of CA-423, it is promising for anticancer therapy. 相似文献
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E V Parfenova D G Popov A A Novikov V E Sterkin A Ia Strongin A Iu Aksinenko O V Korenchenko V I Fetisov I V Martynov V B Sokolov 《Bioorganicheskaia khimiia》1989,15(7):987-989
Influence of O,O,-diethyl-1-(N-alpha-hydrohexafluoroisobutyryl)amino-1- methylpropylphosphonate and O,O-diisobutyl-1-[2-(ethoxycarbonyl)aminoperfluoroprop-2-yl] -1- methylpropylphosphonate on the level of production of human proinsulin secreted by a genetically engineered culture Bacillus subtilis AJ 73 (pBINS1.0.) has been studied. The above phosphonates, being non-toxic for microorganisms, reduced degradation of proinsulin by serine proteinases. 相似文献
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Galina F. Makhaeva Alexey Y. Aksinenko Vladimir B. Sokolov Olga G. Serebryakova Rudy J. Richardson 《Bioorganic & medicinal chemistry letters》2009,19(19):5528-5530
Acetylcholinesterase and butyrylcholinesterase inhibitors are potential cognition enhancers in Alzheimer disease. O,O-Dialkylphosphate inhibitors with 1-substituted 2,2,2-trifluoroethoxy leaving groups were synthesized by phosphonate–phosphate rearrangement. Substituents in the 1-position of the leaving group along with the O-alkyl groups modulated potency and selectivity against acetylcholinesterase, butyrylcholinesterase, and carboxylesterase. 相似文献
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An aqueous solution of the (+)-monoethyl ester of N-(l′-hydroxymethyl-)propyl-α-aminobenzylphosphonic acid has been proposed as a suitable chiral eluent for enantiomeric analysis of amino acids by ligand-exchange chromatography. Asymmetric synthesis of the chiral selector using (−)-(R)-2-aminobutan-1-ol as a starting reactant is described. The dependence of the parameters of separation of valine enantiomers on concentration of the complexing ion, pH, and temperature has been investigated. It is shown that the order in which enantiomers are eluted from a column depends on the concentration of the complexing ion and pH. © 1996 Wiley-Liss, Inc. 相似文献
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V. V. Grigoriev V. L. Zamoyski A. V. Aksinenko V. B. Sokolov S. O. Bachurin 《Doklady. Biochemistry and biophysics》2018,483(1):293-296
Using the patch-clamp method in the whole-cell configuration, we showed that the new derivatives of 2-aminothiophene-3-carboxylic acid, which were synthesized by us earlier, can both block (compound 1) and potentiate (compound 2) calcium-activated chloride currents in single rat cerebellar Purkinje cells. 相似文献