Extremely Sensitive Photonic Crystal Fiber–Based Cancer Cell Detector in the Terahertz Regime

A new photonic crystal fiber (PCF)–based, hollow-core, optical waveguide is proposed and numerically investigated to quickly identify numerous species of cancerous cells in the human body. Typical and cancerous cells have different refractive indices (RIs), and via this characteristic, the other important optical parameters are evaluated. The guiding properties of this proposed cancer cell sensor are analyzed in the COMSOL Multiphysics environment which used the finite element method as mathematical tool to solve differential equations. Furthermore, to ensure the highest simulation accuracy, extremely fine mesh elements are introduced. The simulation studies confirm that the proposed sensor, at 2.5 THz, achieves an extremely high relative sensitivity of almost 98% with negligible loss (< 0.025 dB/cm). Furthermore, a high numerical aperture (NA) and spot size, with low modal area, enhance the propagation characteristics of the sensor to a new height. The sensor’s physical structure is very simple so that it can be easily fabricated with modern fabrication technology. Thus, it seems that this sensor will open a new door in the field of detecting and diagnosing different cancer cells.

     

Ergonomics of living environment for the people with special needs

A safe, convenient, sound and healthy living environment is the prerequisite for a good house for the people with special needs. The intention of making a house in such a way that it solves basic problems of fixture and fittings. However the construction phase of a good house is a critical to design inside and outside structures. Often the builders do not know all the factors to be considered that can maintain a safe, hygienic and healthy environment. It is believed that when housing is ergonomically furnished, then a maximum benefit will be achieved. To meet with an individual's specific needs, an analysis of user's requirement is the most important factors to be considered in the design of special houses. Users' data such as anthropometric dimension, users' choices and preferences are also necessary to design a suitable living environment. In this regard, this paper illustrates some ergonomic features to design and develop good houses in terms of how people with restricted mobility and communication can truly be helped residing in their homes and performing their daily living activities. Users' social, medical and engineering needs are highlighted following the process of disability, ageing, or impairments to achieve the maximum level of benefits, and ensuring safe and sound living.     

Adaptation to night shifts and synchronisation processes of night workers

Human beings are accustomed to being active and awake during the day, and asleep and rest at night. Since we live in a society which is organised predominantly along daytime activity, therefore working in the night shift may deeply disrupt our social and family life. It is also a well-known fact that night shift causes fatigue and circadian disruption. The basic manifestation of fatigue and circadian rhythm has been linked to health and safety problems, involving decrements in psychophysical and physiological functions, plus subjective complaints. In this context quantitative relationships between shift work and circadian rhythm need to be assessed to explore suitable time schedule, and to minimise sleep depth and fatigue. There is also a great need to discuss circadian disruption, sleepiness and the increasing cost of work related illness among night workers. In this regard, some aspects of fatigue and circadian disruption caused from night shift work are revealed in this paper aiming to increase workers' health, safety and well being as well as productivity. Light/dark cycle and social stimuli issues acting on the circadian timing systems are also explored to solicit opinions and discussion on the controversy of night work. Suggestions are therefore likewise given to enhance workers' adaptation to night shift and synchronization process.     

Legacy of implementing industrial health and safety in developing countries

Aiming to develop public attention to the hindrance of national and international efforts on industrial health and safety, this paper explores some important issues, such as the reasons for the lack of motivation to implement necessary measures in developing countries. Examples are likewise given to show why working people are significantly exposed to a number of occupational problems that are reflected in a deterioration of their health, safety and well being. In lieu thereof, an introduction of health and safety is not itself a solution, if certain changes are not rationalised according to the local need. While health and safety intervention is concerned, then local need is of prime importance. If individual situation is not clearly outlined, then preventive and control measures can be treated as a de facto measure. Hence immediate attention, collaboration and co-operation is needed from all the concerned parties such as local government authorities, semi-government or private organisations and international communities for proper implementation of work regulations as well as industrial acts and rules in various workplaces in each of the developing countries.     

HFs/ergonomics of assistive technology

An assistive device is designed to accommodate the special needs of disability that can help people with physical, mental or cognitive challenges go through their day-to-day activities with less difficulty. An assistive device usually provide alternatives to functional limitations imposed by the client's disorder, and thereby minimising rehabilitation costs. It is therefore important to know about how assistive technology will function in all the possible aspects of such disabilities and impairements. When designing a technical device, particularly in conjunction with the target user group, ergonomic issues are therefore important to find out the extent to which an assistive device is convenient or not, and to check the quality performance of assistive technology. Since the question of the match or mismatch of an assistive device and a disabled person requires much attention, it is therefore suggested that paying attention on how an assistive device be ergonomically designed and developed is important. Ergonomic applications are to be applied for increasing motivation of prospective customers through innovative performance of AT. The authors believe that there are opportunities in ergonomic applications to manufacture an assistive device as unique, cost saving, and allows less exertation and reduces energy consumption when it is used. Hence this paper highlights human factors and/or ergonomics consideration in the process of design and development of assistive devices synchronising with gerontechnological research and development aiming to emphasise user's requirement.     

Human aspects of shift work in the developing countries--I: A case study in Bangladesh

There currently is little information available that allows objective prediction of psychosocial risks and benefits associated with the shift work in the developing countries. To provide such information, this study assessed possible differential effects of fatigue associated with the shift workers' attitude, job satisfaction, psychosocial problems, and other difficulties. Data were collected from the subjective responses on various scales using questionnaire among sixty adult male subjects working on a weekly rotating three-shift system in a shoe factory in Bangladesh. The results indicated that shift work is associated with negative aspects of disturbing their family, conjugal and social lives, curtailed leisure activities, created difficulties in meeting their friends, caused irregularity of their mealtime, affected sleep and caused health problems. However, the effect is significant only for such feelings of social and family aspects, as well as sleepy and lively hood but no significant main effects of shift schedule are observed for any of the behavioural and organizational context.     

Bacteriophage versus antibiotic therapy on gut bacterial communities of juvenile green turtle,Chelonia mydas

Green turtles are endangered marine herbivorous hindgut fermenters that contribute to a variety of marine ecosystems. Debilitated turtles are often rehabilitated in turtle hospitals. Since accurate diagnosis of disease is difficult, broad-spectrum antibiotics are routinely used as a general treatment, potentially causing collateral damage to the gut microbiome of the patient. Here, we evaluated the concept of the application of bacteriophage (phages) to eliminate targeted intestinal bacteria as an alternative to a broad-spectrum antibiotic (enrofloxacin) in clinically healthy, captive green turtles. Additionally, the impact of a broad-spectrum antibiotic (enrofloxacin) and phage therapy on the gut bacterial communities of green turtles was evaluated. Gut bacterial communities in faecal samples were analysed by sequencing the V1-V3 regions of the bacterial 16S rRNA. Bacteria-specific phage cocktails significantly (P < 0.05) reduced targeted Acinetobacter in phage-treated turtles during the therapy. Compared to control, no significant difference was observed in the bacterial diversity and compositions in phage-treated turtles. In contrast, bacterial diversity was significantly (P < 0.05) reduced in antibiotic-treated turtles at day 15 and throughout the trial. The alteration in the bacterial microbiota of antibiotic-treated turtles was largely due to an increase in abundance of Gram-positive Firmicutes and a concurrent decrease in Gram-negative Bacteroidetes, Proteobacteria and Verrucomicrobia. Additionally, we observed the relative abundance of several bacteria at lower taxonomic level was much less affected by phages than by antibiotics. These data offer the proof of concept of phage therapy to manipulate transient as well as indigenous bacterial flora in gut-related dysbiosis of turtles.