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Olusola AO Obodozie OO Nssien M Adaramoye A Adesanoye O Odama LE Emerole GO 《Biological trace element research》2004,98(3):265-274
The concentrations of copper, iron, and zinc in the major organs of Wistar albino (Rattus norvegicus) and wild black rats (Rattus rattus) were measured by means of atomic absorption spectroscopy. The copper levels in the kidneys and liver of the Wistar albino rats (WARs) were significantly higher (p<0.05) than in the wild black rats (WBRs). There were no significant differences in the concentrations of zinc in the liver, lungs, kidneys, and brain between the two study groups, but zinc was significantly higher in the spleen (p<0.05) and lower in the heart (p<0.05) of WAR, compared to WBRs. Iron was significantly higher (p<0.05) in the heart and spleen of WBRs, compared to WARs.There were no extreme differences in the organ concentrations of trace elements between the two species, but, cumulatively, the WARs tend to have higher metallic concentrations in their system than the WBRs. The potential of these differences on the experimental results should not be overlooked and will serve as basis to further consider the complex interrelationships of these animals in their microenvironments and macroenvironments. 相似文献
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A. O. Olusola O. O. Obodozie M. Nssien A. Adaramoye O. Adesanoye L. E. Odama G. O. Emerole 《Biological trace element research》2004,98(3):265-273
The concentrations of copper, iron, and zinc in the major organs of Wistar albino (Rattus norvegicus) and wild black rats (Rattus rattus) were measured by means of atomic absorption spectroscopy. The copper levels in the kidneys and liver of the Wistar albino
rats (WARs) were significantly higher (p<0.05) than in the wild black rats (WBRs). There were no significant differences in the concentrations of zinc in the liver,
lungs, kidneys, and brain between the two study groups, but zinc was significantly higher in the spleen (p<0.05) and lower in the heart (p<0.05) of WAR, compared to WBRs. Iron was significantly higher (p<0.05) in the heart and spleen of WBRs, compared to WARs.
There were no extreme differences in the organ concentrations of trace elements between the two species, but, cumulatively,
the WARs tend to have higher metallic concentrations in their system than the WBRs. The potential of these differences on
the experimental results should not be overlooked and will serve as basis to further consider the complex interrelationships
of these animals in their microenvironments and macroenvironments. 相似文献
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Olajuyin Ayobami Matthew Yang Maohua Mu Tingzhen Tian Jiangnan Thygesen Anders Adesanoye Omolola Abidemi Adaramoye Oluwatosin Adekunle Song Andong Xing Jianmin 《Bioprocess and biosystems engineering》2018,41(10):1497-1508
Bioprocess and Biosystems Engineering - A biorefinery process for high yield production of succinic acid from biomass sugars was investigated using recombinant Escherichia coli. The major problem... 相似文献
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Omolola A. Adesanoye Olorunfemi R. Molehin Adetutu A. Delima Adeniyi S. Adefegha Ebenezer O. Farombi 《Cell biochemistry and function》2013,31(7):545-550
Reactive oxygen species (ROS) have been implicated in the aetiology of several pathological and degenerative diseases. The protective effect of natural products possessing antioxidant properties has played a crucial role in ameliorating these deleterious effects. This study investigated the chemoprotective properties of the methanolic extract of Vernonia amygdalina (MEVA) in an experimental model of tert‐butyl hydroperoxide (t‐BHP)–induced human erythrocyte lysis in vitro. Haemolysis was induced by incubating erythrocytes with t‐BHP (2 and 3 mM) in vitro. Samples of erythrocyte suspensions were removed at different intervals over a 6‐h period, and the degree of haemolysis was measured. The anti‐haemolytic effect of MEVA at 25–150 µg ml–1 concentrations on the samples were assessed and compared with Triton X‐100. Administration of t‐BHP at 2‐ and 3‐mM concentrations significantly (p < 0.05) induced erythrocyte lysis by 37.5% and 31.4%, respectively. The addition of MEVA, however, reduced t‐BHP–induced erythrocyte lysis significantly (p < 0.05) by 39.3%, 48.4%, 67.3% and 73.4% at 25, 50, 100 and 150 µg ml–1 concentrations, respectively. MEVA likewise protected against t‐BHP–induced lipid peroxidation significantly (p < 0.05) at 100 and 150 µg ml–1 by the fourth hour and non‐significantly (p > 0.05) at all concentrations by the sixth hour. The reduced glutathione level was, however, increased with the administration of t‐BHP, while a delayed addition of MEVA had no protective effect on the t‐BHP–induced cell lysis. These findings therefore suggest that MEVA may have protective antioxidant properties, making it suitable for incorporation into food and drug products. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献
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