排序方式: 共有2条查询结果,搜索用时 0 毫秒
1
1.
Pascaline Priou Marc Le Vaillant Nicole Meslier Audrey Paris Thierry Pigeanne Xuan-Lan Nguyen Claire Alizon Acya Bizieux-Thaminy Laurene Leclair-Visonneau Marie-Pierre Humeau Frédéric Gagnadoux for the IRSR sleep cohort group 《PloS one》2014,9(12)
Obstructive sleep apnea (OSA) and short sleep duration are individually
associated with an increased risk for hypertension (HTN). The aim of this
multicenter cross-sectional study was to test the hypothesis of a cumulative
association of OSA severity and short sleep duration with the risk for prevalent
HTN. Among 1,499 patients undergoing polysomnography for suspected OSA, 410
(27.3%) previously diagnosed as hypertensive and taking antihypertensive
medication were considered as having HTN. Patients with total sleep time (TST)
<6 h were considered to be short sleepers. Logistic regression procedures
were performed to determine the independent association of HTN with OSA and
sleep duration. Considering normal sleepers (TST ≥6 h) without OSA as the
reference group, the odds ratio (OR) (95% confidence intervals) for
having HTN was 2.51 (1.35–4.68) in normal sleepers with OSA and 4.37
(2.18–8.78) in short sleepers with OSA after adjustment for age, gender,
obesity, diabetes, depression, current smoking, use of thyroid hormones, daytime
sleepiness, poor sleep complaint, time in bed, sleep architecture and
fragmentation, and study site. The risk for HTN appeared to present a cumulative
association with OSA severity and short sleep duration (p<0.0001 for linear
trend). The higher risk for HTN was observed in short sleepers with severe OSA
(AHI ≥30) (OR, 4.29 [2.03–9.07]). In patients investigated
for suspected OSA, sleep-disordered breathing severity and short sleep duration
have a cumulative association with the risk for prevalent HTN. Further studies
are required to determine whether interventions to optimize sleep may contribute
to lower BP in patients with OSA. 相似文献
2.
Gagnadoux F Le Vaillant M Goupil F Pigeanne T Chollet S Masson P Humeau MP Bizieux-Thaminy A Meslier N;IRSR sleep cohort group 《PloS one》2011,6(8):e22503
Background
Long-term adherence is a major issue in patients receiving home continuous positive airway pressure (CPAP) therapy for obstructive sleep apnea-hypopnea syndrome (OSAHS). In a multicenter prospective cohort (the Institut de Recherche en Santé Respiratoire des Pays de la Loire [IRSR] sleep cohort) of consecutive OSAHS patients in whom CPAP had been prescribed for at least 90 days, we studied the impact on long-term treatment adherence of socioeconomic factors, patients and disease characteristics prior to CPAP initiation.Methods and Principal Findings
Among 1,141 patients in whom CPAP had been prescribed for an average of 504±251 days (range: 91 to 1035), 674 (59%) were adherent with a mean daily use of CPAP≥4 h (mean: 6.42±1.35 h). Stepwise regression analysis identified 4 independent factors of CPAP adherence including apnea-hypopnea index (AHI) (OR: 1.549, 95%CI 1.163 to 2.062 for AHI≥30 vs. AHI<30; p = 0.003), body mass index (BMI) (OR: 1.786, 95%CI 1.131 to 2.822 for BMI≥25 and <30 kg/m2, p = 0.01; OR: 1.768, 95%CI 1.145–2.731 for BMI≥30 kg/m2, p = 0.01 vs. BMI<25 kg/m2), employment status (OR: 1.414, 95%CI 1.097–1.821 for retired vs. employed; p = 0.007) and marital status (OR: 1.482, 95%CI 1.088–2.019 for married or living as a couple vs. living alone; p = 0.01). Age, gender, Epworth sleepiness scale, depressive syndrome, associated cardiovascular morbidities, educational attainment and occupation category did not influence CPAP adherence.Conclusions
Marital status and employment status are independent factors of CPAP adherence in addition to BMI and disease severity. Patients living alone and/or working patients are at greater risk of non-adherence, whereas adherence is higher in married and retired patients. These findings suggest that the social context of daily life should be taken into account in risk screening for CPAP non-adherence. Future interventional studies targeting at-risk patients should be designed to address social motivating factors and work-related barriers to CPAP adherence. 相似文献
1