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Khan Muhammad Tahir Zeb Muhammad Tariq Ahsan Hina Ahmed Abrar Ali Arif Akhtar Khalid Malik Shaukat Iqbal Cui Zhilei Ali Sajid Khan Anwar Sheed Ahmad Manzoor Wei Dong-Qing Irfan Muhammad 《Archives of microbiology》2021,203(1):59-66
Archives of Microbiology - Severe acute respiratory syndrome virus 2 (SARS-CoV-2) belongs to the single-stranded positive-sense RNA family. The virus contains a large genome that encodes four... 相似文献
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Yousafi Qudsia Batool Jannat Khan Muhammad Saad Perveen Tamsila Sajid Muhammad Wasim Hussain Abrar Mehmood Asim Saleem Shahzad 《International journal of peptide research and therapeutics》2021,27(1):351-351
International Journal of Peptide Research and Therapeutics - The original version of the article unfortunately contained a typo in co-author name. 相似文献
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Abrar Ahmad Mustabeen 《Archives Of Phytopathology And Plant Protection》2013,46(14):1343-1346
A pot experiment was carried out to observe the response of black gram (Phaseolus mungo L.) to acid rain. The plants were exposed to different concentrations of simulated acid rain (pH 5, 4, 3). The symptoms such as injuries and necrotic spots appeared on the leaves. Plant growth, yield and photosynthetic pigments were suppressed greatly in all the treatments. The suppressions were directly proportional to the exposure levels of acid rain on the plants. 相似文献
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Xin Li Liming Liang Mingfeng Zhang Fengju Song Hongmei Nan Li-E Wang Qingyi Wei Jeffrey E. Lee Christopher I. Amos Abrar A. Qureshi Jiali Han 《Human genetics》2013,132(7):793-801
Previous biological studies showed evidence of a genetic link between obesity and pigmentation in both animal models and humans. Our study investigated the individual and joint associations between obesity-related single nucleotide polymorphisms (SNPs) and both human pigmentation and risk of melanoma. Eight obesity-related SNPs in the FTO, MAP2K5, NEGR1, FLJ35779, ETV5, CADM2, and NUDT3 genes were nominally significantly associated with hair color among 5,876 individuals of European ancestry. The genetic score combining 35 independent obesity-risk loci was significantly associated with darker hair color (beta-coefficient per ten alleles = 0.12, P value = 4 × 10?5). However, single SNPs or genetic scores showed non-significant association with tanning ability. We further examined the SNPs at the FTO locus for their associations with pigmentation and risk of melanoma. Among the 783 SNPs in the FTO gene with imputation R 2 quality metric >0.8 using the 1,000 genome data set, ten and three independent SNPs were significantly associated with hair color and tanning ability respectively. Moreover, five independent FTO SNPs showed nominally significant association with risk of melanoma in 1,804 cases and 1,026 controls. But none of them was associated with obesity or in linkage disequilibrium with obesity-related variants. FTO locus may confer variation in human pigmentation and risk of melanoma, which may be independent of its effect on obesity. 相似文献
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Iqbal Tahir Ijaz Mohsin Javaid Muhammad Rafique Muhammad Riaz Khalid Nadeem Tahir Muhammad Bilal Nabi Ghulam Abrar Muhammad Afsheen Sumera 《Plasmonics (Norwell, Mass.)》2019,14(1):147-154
Plasmonics - Effect of different gold (Au) grating structures on light absorption in solar cell is investigated by finite elemental analysis using COMSOL multiphysics-RF module. The geometry of the... 相似文献
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Asim Mehmood Umal Baneen Ahmad Zaheer Muhammad Wasim Sajid Abrar Hussain Shahzad Saleem Qudsia Yousafi Hamid Rashid Hassan Riaz Awais Ihsan Farrukh Jamil Yasar Sajjad Nageena Zahid Muhammad Shahzad Anjam Muhammad Arshad Zeenat Mirza Sajjad Karim Mahmood Rasool 《Saudi Journal of Biological Sciences》2019,26(7):1485-1491
ObjectivePhosphorous is an essential micronutrient of plants and involved in critical biological functions. In nature, phosphorous is mostly present in immobilized inorganic mineral and in the fixed organic form including phytic acid and phosphoesteric compounds. However, the bioavailability of bound phosphorous could be enhanced by the use of phosphate solubilizing microorganisms such as bacteria and fungi. The phytases are widespread in an environment and have been isolated from different sources comprising bacteria and fungi.MethodologyIn current studies, we show the successful use of gamma rays and EMS (Ethyl Methane Sulphonate) mutagenesis for enhanced activity of phytases in a fungal strain Sporotrichum thermophile.ResultsWe report an improved strain ST2 that could produce a clear halo zone around the colony, up to 24 mm. The maximum enzymatic activity was found of 382 U/mL on pH 5.5. However, the phytase activity was improved to 387 U/ml at 45 °C. We also report that the mutants produced through EMS showed the greater potential for phytase production.ConclusionThe current study highlights the potential of EMS mutagenesis for strain improvement over physical mutagens. 相似文献
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Sarah Findakly Vikas Daggubati Galo Garcia III Sydney A. LaStella Abrar Choudhury Cecilia Tran Amy Li Pakteema Tong Jason Q. Garcia Natasha Puri Jeremy F. Reiter Libin Xu David R. Raleigh 《The Journal of cell biology》2021,220(1)
Vertebrate Hedgehog signals are transduced through the primary cilium, a specialized lipid microdomain that is required for Smoothened activation. Cilia-associated sterol and oxysterol lipids bind to Smoothened to activate the Hedgehog pathway, but how ciliary lipids are regulated is incompletely understood. Here we identified DHCR7, an enzyme that produces cholesterol, activates the Hedgehog pathway, and localizes near the ciliary base. We found that Hedgehog stimulation negatively regulates DHCR7 activity and removes DHCR7 from the ciliary microenvironment, suggesting that DHCR7 primes cilia for Hedgehog pathway activation. In contrast, we found that Hedgehog stimulation positively regulates the oxysterol synthase CYP7A1, which accumulates near the ciliary base and produces oxysterols that promote Hedgehog signaling in response to pathway activation. Our results reveal that enzymes involved in lipid biosynthesis in the ciliary microenvironment promote Hedgehog signaling, shedding light on how ciliary lipids are established and regulated to transduce Hedgehog signals. 相似文献
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The prehydrolysis liquor (PHL) of the kraft‐based dissolving pulp production process contains various amounts of hemicelluloses that can be utilized in the production of value‐added products. In this work, a new process was proposed for removing the inhibitors of PHL via employing a flocculation concept to facilitate the utilization of hemicelluloses. Lignin, lignocelluloses/cationic polymer complexes, and possibly ethanol are the main products of this process. This process has been experimentally evaluated with an industrially produced PHL and cationic polymers. The results showed that 16% of lignin, 19% of acetic acid, 43% of furfural, and insignificant amount of sugars were removed from PHL via pretreating PHL with acid and lime at pH 7. Furthermore, by adding 0.4–0.5 mg g?1 polydiallyldimethylammonium chloride (PDADMAC) or chitosan to the pretreated PHL, 12–14% acetic acid, 40–50% furfural, 5–6% monomeric sugars, and 25% oligomeric sugars were removed from the PHL. The complexes made from these components may be applied as organic fillers in various industries. Alternatively, by adding 1.2 or 1.4 mg g?1 PDADMAC or chitosan to the pretreated PHL, 30 or 35% of lignin was removed, respectively, which induced complexes that could be used as a fuel source. The composition of the complexes formed was also determined in this work. © 2012 American Institute of Chemical Engineers Biotechnol. Prog., 28: 998–1004, 2012 相似文献