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排序方式: 共有72条查询结果,搜索用时 15 毫秒
1.
P I Tashkhodzhaev A T Dusmetov P R Alimkhodzhaeva M S Gil'dieva B A Abdullaev 《T?Sitologii?a i genetika》1988,22(5):52-55
Administration of rovicoort, a new pesticide, in various single doses (75, 150, 380 mg/kg) to mongrel white male rats intragastrically on empty stomach showed that the doses of 75 and 150 mg/kg stimulated adaptive mechanisms of the organism resulting in the increase of diameter of both seminiferous tubules and the number of Sertoli cells as well as fertilizing capacity of spermatozoa. Dominant lethal mutation in early postmeiotic cells was induced after the drug exposure of 150 and 380 mg/kg doses. 相似文献
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The effect of diethyl pyrocarbonate on chromatophores and isolated pigment--protein complexes of Chromatium minutissimum was studied. It is shown that modification of histidine residues results in the destruction of the core antenna LHI (B880) and in a spectral shift from 850 to 830 nm in the peripheral antenna LHII (B800-850). In the purple sulfur bacterium Chromatium minutissimum the pigment--protein complexes B800-B850 (peripheral antenna, LHII) and B880 (core antenna, LHI) collect and transmit the absorbed light energy to the reaction centers. The composition of pigments and proteins as well as primary structure of the majority of polypeptides in both types of complexes from various photosynthetic bacteria have been determined. 相似文献
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Renaud S Pugacheva EM Delgado MD Braunschweig R Abdullaev Z Loukinov D Benhattar J Lobanenkov V 《Nucleic acids research》2007,35(21):7372-7388
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Biophysics - We have previously shown that short-term moderate (30°C) hypothermia contributed to a significant increase in the intensity of free radical processes and changes in a number of... 相似文献
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I. Yu. Strelkova S. A. Abdullaev G. P. Snigireva V. G. Bezlepkin A. I. Gaziev 《Biochemistry (Moscow) Supplemental Series B: Biomedical Chemistry》2011,5(1):88-93
Quantitative and qualitative changes in circulating extracellular DNA (ec-DNA) of blood plasma are considered as markers for
diagnosis and prognosis of tumor pathology. We have investigated the content of mutant copies of the circulating mitochondrial
DNA (ec-mtDNA) in blood plasma in 8 patients with lung cancer before and after radiotherapy as well as in healthy young and
elderly donors. It was found that in plasma of healthy elderly donors the proportion of ec-mtDNA with mutations (in the total
circulating DNA) is much higher than in young donors. Before radiotherapy the proportion of ec-mtDNA with mutations was higher
in plasma of lung cancer patients (aged 70–76 years) than that of healthy elderly donors. After radiotherapy of lung cancer
patients a twofold increase in the proportion of ec-mtDNA with mutations was observed in total circulating plasma DNA. This
may be attributed to release of mutant DNA copies from dying tumor cells and also from normal cells injured by the radiation
treatment. 相似文献
9.
Abdurakhmonov IY Abdullaev AA Saha S Buriev ZT Arslanov D Kuryazov Z Mavlonov GT Rizaeva SM Reddy UK Jenkins JN Abdullaev A Abdukarimov A 《The Journal of heredity》2005,96(6):644-653
Cotton (Gossypium hirsutum L.) leaf defoliation has a significant ecological and economical impact on cotton production. Thus the utilization of a natural leaf defoliation trait, which exists in wild diploid cotton species, in the development of tetraploid cultivated cotton will not only be cost effective, but will also facilitate production of very high-grade fiber. The primary goal of our research was to tag loci associated with natural leaf defoliation using microsatellite markers in Upland cotton. The F2 populations developed from reciprocal crosses between the two parental cotton lines--AN-Boyovut-2 (2n = 52), a late leaf defoliating type, and Listopad Beliy (2n = 52), a naturally early leaf defoliating type--demonstrated that the naturally early leaf defoliation trait has heritability values of 0.74 and 0.84 in the reciprocal F2 population. The observed phenotypic segregation difference in reciprocal crosses suggested a minor cytoplasmic effect in the phenotypic expression of the naturally early leaf defoliation trait. Results from the Kruskal-Wallis (KW) nonparametric test revealed that JESPR-13 (KW = 6.17), JESPR-153 (KW = 9.97), and JESPR-178 (KW = 13.45) Simple sequence repeat (SSR) markers are significantly associated with natural leaf defoliation in the mapping population having stable estimates at empirically obtained critical thresholds (P < .05-.0001). JESPR-178 revealed the highest estimates (P < .0001) for association with the natural leaf defoliation trait, exceeding maximum empirical threshold values. JESPR-178 was assigned to the short arm of chromosome 18, suggesting indirectly that genes associated with natural leaf defoliation might be located on this chromosome. This microsatellite marker may have the potential for use to introgress the naturally early leaf defoliation quantitative trait loci (QTL) from the donor line Listopad Beliy to commercial varieties of cotton through marker-assisted selection programs. 相似文献
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Impairments of mitochondrial genome are associated with a wide spectrum of degenerative diseases, development of tumors, aging,
and cell death. We studied the content of mitochondrial DNA (mtDNA) with mutations and the total content of mutations in the
brain and the spleen of mice subjected to X-ray irradiation at a dose of 1–5 Gy at 8–28 days after treatment. In these mice,
we studied the number of mutant copies of extracellular mtDNA (ec-mtDNA) and its total content in blood plasma. We estimated
mutations in control and irradiated mice using cleavage of heteroduplexes prepared by hybridization of PCR amplicons of mtDNA
(D-loop region) mediated by CEL-I endonuclease, an enzyme that specifically cleaves unpaired bases. Changes in the total number
of mtDNA copies relative to nuclear DNA were assessed by real time PCR using the ND-4 and GAPDH genes, respectively. We found that the number of mutant mtDNA copies was significantly increased in the brain and the spleen
of irradiated mice and reached the maximum level at the eighth day after treatment; it then decreased by the 28th day after
treatment. In nuclear genes similar to mutagenesis, mutagenesis of mtDNA in the brain and spleen tissues linearly depended
on irradiation dose. In contrast to mutant nuclear genes, most mutant mtDNA copies were eliminated in the brain and spleen
tissues, whereas the total content of mtDNA did not change within 28 days after irradiation. Our data show that, during this
period, a high level of ec-mtDNA with mutations was observed in DNA circulating in blood plasma with the maximum level found
at the 14th day. We suppose that mutant mtDNA copies are eliminated from cells of animals subjected to irradiation during
the posttreatment period. Higher content of ec-mtDNA in blood plasma can be considered as a potential marker of radiation
damage to the body. 相似文献