排序方式: 共有32条查询结果,搜索用时 15 毫秒
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Dr. Sherif M. H. Sanad Alshimaa A. M. Abdelsalam Aya A. Gamal Eldin Esraa H. Abdelfattah Fatma R. M. Hussein Nada G. Mohammed Nariman A. S. Taha Prof. Dr. Ahmed E. M. Mekky 《化学与生物多样性》2023,20(6):e202300546
An efficient protocol was adopted to efficiently prepare three new series of bis(pyrazolo[1,5-a]pyrimidines) linked to different spacers. The new bis(pyrazolo[1,5-a]pyrimidines) were prepared in 80–90 % yields by reacting the respective bis(enaminones) and 4-(4-substituted benzyl)-1H-pyrazole-3,5-diamines in pyridine at reflux temperature for 5–7 h. The new products showed a wide spectrum of antibacterial activity against six different bacterial strains. In general, propane- and butane-linked bis(pyrazolo[1,5-a]pyrimidines), which are attached to 3-(4-methyl- or 4-methoxybenzyl) units, had the best antibacterial activity with minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values up to 2.5 and 5.1 μM, respectively. Additionally, the previous products demonstrated promising MurB inhibitory activity with IC50 values up to 7.2 μM. 相似文献
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Abdelsalam Essam M. Samer Mohamed 《Reviews in Environmental Science and Biotechnology》2019,18(3):525-541
Reviews in Environmental Science and Bio/Technology - Biomass energy, especially biogas production, is a renewable and sustainable form of energy. Biogas is becoming more important due to its... 相似文献
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Hassaneen E El-Din Sallam A Abo-Ghalia A Moriyama Y Karpova SG Abdelsalam S Matsushima A Shimohigashi Y Tomioka K 《Journal of biological rhythms》2011,26(1):3-13
Pigment-dispersing factor (PDF) is a neuropeptide widely distributed in insect brains and plays important roles in the circadian system. In this study, we used RNA interference to study the role of the pigment-dispersing factor (pdf) gene in regulating circadian locomotor rhythms in the cricket, Gryllus bimaculatus. Injections of pdf double-stranded RNA (dspdf) effectively knocked down the pdf mRNA and PDF peptide levels. The treated crickets maintained the rhythm both under light-dark cycles (LD) and constant darkness (DD). However, they showed rhythms with reduced nocturnal activity with prominent peaks at lights-on and lights-off. Entrainability of dspdf-injected crickets was higher than control crickets as they required fewer cycles to resynchronize to the LD cycles shifted by 6 h. The free-running periods of the dspdf-injected crickets were shorter than those of control crickets in DD. These results suggest that PDF is not essential for the rhythm generation but involved in control of the nocturnality, photic entrainment, and fine tuning of the free-running period of the circadian clock. 相似文献
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Abdelsalam S Uemura H Umezaki Y Saifullah AS Shimohigashi M Tomioka K 《Journal of insect physiology》2008,54(7):1205-1212
Pigment-dispersing factor (PDF) is a neuropeptide playing important roles in insect circadian systems. In this study, we morphologically and physiologically characterized PDF-immunoreactive neurons in the optic lobe and the brain of the cricket Gryllus bimaculatus. PDF-immunoreactivity was detected in cells located in the proximal medulla (PDFMe cells) and those in the dorsal and ventral regions of the outer chiasma (PDFLa cells). The PDFMe cells had varicose processes spread over the frontal surface of the medulla and the PDFLa cells had varicose mesh-like innervations in almost whole lamina, suggesting their modulatory role in the optic lobe. Some of PDFMe cells had a hairpin-shaped axonal process running toward the lamina then turning back to project into the brain where they terminated at various protocerebral areas. The PDFMe cells had a low frequency spontaneous spike activity that was higher during the night and was often slightly increased by light pulses. Six pairs of PDF-immunoreactive neurons were also found in the frontal ganglion. Competitive ELISA with anti-PDF antibodies revealed daily cycling of PDF both in the optic lobe and cerebral lobe with an increase during the night that persisted in constant darkness. The physiological role of PDF is discussed based on these results. 相似文献
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Self‐Powered Wireless Sensor Node Enabled by a Duck‐Shaped Triboelectric Nanogenerator for Harvesting Water Wave Energy
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Abdelsalam Ahmed Zia Saadatnia Islam Hassan Yunlong Zi Yi Xi Xu He Jean Zu Zhong Lin Wang 《Liver Transplantation》2017,7(7)
This paper presents a fully enclosed duck‐shaped triboelectric nanogenerator (TENG) for effectively scavenging energy from random and low‐frequency water waves. The design of the TENG incorporates the freestanding rolling mode and the pitch motion of a duck‐shaped structure generated by incident waves. By investigating the material and structural features, a unit of the TENG device is successfully designed. Furthermore, a hybrid system is constructed using three units of the TENG device. The hybrid system achieves an instantaneous peak current of 65.5 µA with an instantaneous output power density of up to 1.366 W m?2. Following the design, a fluid–solid interaction analysis is carried out on one duck‐shaped TENG to understand the dynamic behavior, mechanical efficiency, and stability of the device under various water wave conditions. In addition, the hybrid system is experimentally tested to enable a commercial wireless temperature sensor node. In summary, the unique duck‐shaped TENG shows a simple, cost‐effective, environmentally friendly, light‐weight, and highly stable system. The newly designed TENG is promising for building a network of generators to harvest existing blue energy in oceans, lakes, and rivers. 相似文献
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Rania A. A. Salama Rania M. Abdelsalam O. M. E. Abdel‐Salam Mahmoud M. khattab Neveen A. Salem Zakaria A. El‐Khyat Fatma A. Morsy Ezz‐El Din S. Eldenshary 《Journal of biochemical and molecular toxicology》2019,33(3)
The current study aimed to evaluate the role of cannabinoid receptors in the regulation of gastric acid secretion and oxidative stress in gastric mucosa. To fulfill this aim, gastric acid secretion stimulated with histamine (5 mg/kg, subcutaneous [SC]), 2‐deoxy‐ d ‐glucose (D‐G) (200 mg/kg, intravenous) or ‐carbachol (4 μg/kg, SC) in the 4‐hour pylorus‐ligated rats. The CB1R agonist ( N‐arachidonoyl dopamine, 1 mg/kg, SC) inhibited gastric acid secretion stimulated by D‐G and carbachol but not in histamine, reduced pepsin content, and increased mucin secretion. Furthermore, it decreased malondialdehyde (MDA) and nitric oxide (NO) contents with an increase in glutathione (GSH) and paraoxonase 1 (PON‐1). Meanwhile, CB2R antagonist (AM630, 1 mg/kg, SC) inhibited gastric acid secretion stimulated by D‐G and reduced MDA and NO contents with an increase in GSH and PON‐1. Meanwhile, CB1R antagonist rimonabant or CB2R agonist GW 405833 had no effect on stimulated gastric acid secretion. Therefore, both CB1R agonist and CB2R antagonist may exert antisecretory and antioxidant potential in the stomach. 相似文献
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By M. Abdelsalam K. Nakanishi K. Yonemura T. Itami S. C. Chen T. Yoshida 《Zeitschrift fur angewandte Ichthyologie》2009,25(4):442-446
The strong clinical similarity between Lancefield group C Streptococcus dysgalactiae subsp. dysgalactiae (GCSD) and Lactococcus garvieae infections, characterized by development of necrotic lesions in the caudal peduncle of infected fish, has hindered differentiation of these two strains, making rapid and accurate diagnosis of diseased fish in fish farms difficult. GCSD from diseased fish were presumptively identified and isolated using Todd-Hewitt agar containing 30 μg ml−1 of Congo Red dye (TH-CR). TH-CR agar was also used to detect and presumptively identify the GCSD obtained from artificially or naturally infected fish. Orange GCSD colonies distinct from the L. garvieae colonies were observed on the TH-CR agar; thus, TH-CR agar can be used to detect and identify GCSD isolated from infected fish. 相似文献
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Khaled Mahmoud Abdelsalam 《Limnology》2012,13(1):171-179
Quantitative samples of benthic invertebrates were collected from a sandy riverbed of a mountainous stream (Kozu site of Takami-gawa
stream, Nara Prefecture), central Japan by core samplers in five sampling occasions through the years 2008–2009. A total of
120 taxa were identified, representing 55 families and 97 genera. Insects formed about 92% of the total recorded taxa and
88% of individuals’ abundance. A total of 111 taxa of aquatic insects, belonging to 49 families and 92 genera, were identified
and represented by ten orders. Oligochaeta and Acari were dominant non-insect invertebrates. Diptera was the most diverse
insect group, followed by Trichoptera and Ephemeroptera. Dominant taxa were mesoinvertebrates, younger stages of macroinvertebrates,
both of which predominantly inhabit the interstitial zone of a sandy riverbed. Both taxon richness and invertebrate abundance
were higher in February 2009 and lower in April and August 2008. A few major invertebrate taxa demonstrated distinct seasonal
trends; i.e. Nymphomyia alba, Rheosmittia, and Corynoneura were abundant in February 2009. Newly hatched larvae of Larcasia akagiae were abundant in May 2008. This study also demonstrated the effectiveness of core samplers to collect small-sized benthic
fauna that inhabit the interstitial or hyporheic zone of the sandy riverbed. 相似文献