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A. G rski V. Castronovo B. Stepie -Sopniewska P. Grieb M. Ryba T. Mrowiec G. Korczak-Kowalska P. Wierzbicki W. Matysiak B. Dybowska J. Piekarczyk J. Gawalkiewicz P. Kryst A. Borkowski T. Tolloczko 《Cell communication & adhesion》1994,2(3):225-233
Although T cells infiltrate malignant tumors, the local immune response is usually inefficient and tumors escape destruction. While extracellular matrix proteins strongly costimulate T cell responses in normal individuals, our studies indicate that peripheral blood T cells from cancer patients and tumor infiltrating cells respond poorly or are resistant to stimulative signals mediated by collagen I and IV and fibronectin. Moreover, the adhesive properties of cancer T cells are markedly depressed. Those functional deficiencies are paralleled by variable deficits in integrin and non-integrin T cell receptors for extracellular matrix. Immunotherapy with BCG causes a dramatic but transient increase in T cell: ECM interactions. 相似文献
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