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1.
Based on its proven anabolic effects on bone in osteoporosis patients, recombinant parathyroid hormone (PTH1-34) has been evaluated as a potential therapy for skeletal repair. In animals, the effect of PTH1-34 has been investigated in various skeletal repair models such as fractures, allografting, spinal arthrodesis and distraction
osteogenesis. These studies have demonstrated that intermittent PTH1-34 treatment enhances and accelerates the skeletal repair process via a number of mechanisms, which include effects on mesenchymal
stem cells, angiogenesis, chondrogenesis, bone formation and resorption. Furthermore, PTH1-34 has been shown to enhance bone repair in challenged animal models of aging, inflammatory arthritis and glucocorticoid-induced
bone loss. This pre-clinical success has led to off-label clinical use and a number of case reports documenting PTH1-34 treatment of delayed-unions and non-unions have been published. Although a recently completed phase 2 clinical trial of PTH1-34 treatment of patients with radius fracture has failed to achieve its primary outcome, largely because of effective healing
in the placebo group, several secondary outcomes are statistically significant, highlighting important issues concerning the
appropriate patient population for PTH1-34 therapy in skeletal repair. Here, we review our current knowledge of the effects of PTH1-34 therapy for bone healing, enumerate several critical unresolved issues (e.g., appropriate dosing regimen and indications)
and discuss the long-term potential of this drug as an adjuvant for endogenous tissue engineering. 相似文献
2.
We perform first principles total energy calculations to investigate the atomic structures of the adsorption of phenol (C6H5OH) on hexagonal boron nitride (BN) sheets. Calculations are done within the density functional theory as implemented in the
DMOL code. Electron-ion interactions are modeled according to the local-spin-density-approximation (LSDA) method with the
Perdew-Wang parametrization. Our studies take into account the hexagonal h-BN sheets and the modified by defects d-BN sheets.
The d-BN sheets are composed of one hexagon, three pentagons and three heptagons. Five different atomic structures are investigated:
parallel to the sheet, perpendicular to the sheet at the B site, perpendicular to the sheet at the N site, perpendicular to
the central hexagon and perpendicular to the B-N bond (bridge site). To determine the structural stability we apply the criteria
of minimum energy and vibration frequency. After the structural relaxation phenol molecules adsorb on both h-BN and d-BN sheets.
Results of the binding energies indicate that phenol is chemisorbed. The polarity of the system increases as a consequence
of the defects presence which induces transformation from an ionic to covalent bonding. The elastic properties on the BN structure
present similar behavior to those reported in the literature for graphene. 相似文献
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本文记述我国长斑蚜属Tinocallis Matsumura 11种,其中包括6新种;并记述中华彩斑蚜Sinotherioaphis pterothorax zhang et zhong,新属新种。文中所用量度单位为毫米。模式标本存中国科学院动物研究所。 相似文献
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党的十二届三中全会后,我国中等教育和职业教育发展迅速,仅农牧渔业部中专处管辖的地区以上的中专已达637所,各省(市)自治区县办农业职业中学更在迅猛发展。最近召开的全国植物生理教学讨论和学术交流会的300多名代表中,来自各中等农、林、牧、园等学校代表即有84人。这类学校都有植物生理课程,这是一门极为重要的专业基础课,教学质量的好坏直接影响专业人才的培养。因此在这次教学讨论会上,与会的中等农林学校代表一致倡议设立中专 相似文献