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严重急性呼吸综合征(SARS)冠状病毒N蛋白基因的表达及其初步应用 总被引:3,自引:0,他引:3
SARS coronavirus N gene w as expressed by Ecoli expression systemThe expressed protein was p urified and an ELISA method was se t up for detection of SARS virus i nfected patient's serum antibodyT he recombinant SARS coronavirus N protein offers an efficient way fo r serological diagnosis and is use ful for epidemiological study and vaccine development 相似文献
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粘膜免疫戊型肝炎试验性疫苗的研究 总被引:1,自引:0,他引:1
采用原核表达的戊型肝炎病毒结构区基因(HEV ORF2)编码蛋白,与新型人用疫苗佐剂类MF59配制成试验性疫苗,通过粘膜免疫途径免疫实验小鼠,研究其产生粘膜免疫和体液免疫的效果。结果表明,通过滴鼻和灌胃两种粘膜免疫途径免疫BALB/c小鼠,均能诱导小鼠产生针对HEV ORF2试验性疫苗的血清IgG和IgA,血清IgG的抗体滴度为1:800~1:1600,血清IgA抗体滴度为1:100~1:200。对免疫小鼠血清中IgG的动态观察表明,血清抗体可持续存在至少6个月以上。比较类MF159佐剂和传统铝盐佐剂经注射免疫所诱导产生的血清IgG抗体滴度,发现类MF59佐剂可有效增强HEV0RF2重组蛋白的免疫原性4倍左右。类MF159佐剂可诱导粘膜免疫反应,在肠道粘膜部位产生SIgA,滴度为1:100。这些结果为新型戊型肝炎病毒基因工程重组疫苗的研制提供了一条新的思路。 相似文献
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严重急性呼吸综合征(SARS)冠状病毒刺突蛋白基因片段的表达及其初步应用 总被引:4,自引:0,他引:4
SARS virus spike gene fra gment was expressed by Ecoli expr ession systemThe fragment enclose s major neutralization epitope of the virusThe expressed protein wa s purified and an ELISA method was set upBy using the recombinant,tw elve patients' sera were detected The recombinant SARS coronavirus s pike protein offers an efficient wa y for serological diagnosis and is useful for epidemiological survey and vaccin e development 相似文献
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