强磁场下小白鼠大脑的~1H核磁共振成象

分别用FLASH和STEAM脉冲序列完成存活和死亡的小白鼠大脑的核磁共振显微成象及大脑的定域波谱,用相移预饱和方法抑制水峰.实验结果表明,用核磁共振微成象方法能够观察到小白鼠的死、活在大脑定域谱中反映出的差别以及显微图象上解剖细节的差别,其中定域谱反映出的差别尚未见到文献报道.     

High-field (9.4 T) 1H magnetic resonance microscopy of mouse brain

The FLASH and STEAM pulse sequences were used to perform the microimaging and localized spectroscopy of brain of living and dead mice, respectively. The phase-shift presaturation approach was used to sup-press water NMR signal. The experimental results show that the differences in localized spectra and MR images of brain between live and dead mice can be observed by means of magnetic resonance microscopy.