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排序方式: 共有193条查询结果,搜索用时 15 毫秒
121.
《Journal of Industrial Ecology》2002,6(3-4):137-160
We present an input-output analysis of the life-cycle labor, land, and greenhouse gas (GHG) requirements of alternative options for three case studies: investing money in a new vehicle versus in repairs of an existing vehicle (labor), passenger transport modes for a trip between Sydney and Melbourne (land use), and renewable electricity generation (GHG emissions). These case studies were chosen to demonstrate the possibility of rank crossovers in life-cycle inventory (LCI) results as system boundaries are expanded and upstream production inputs are taken into account. They demonstrate that differential convergence can cause crossovers in the ranking of inventories for alternative functional units occurring at second-and higher-order upstream production layers. These production layers are often excluded in conventional process-type life-cycle assessment (LCA) by the delineation of a finite system boundary, leading to a systematic truncation error within the LCI. The exclusion of higher-order upstream inputs can be responsible for ranking crossovers going unnoticed. In this case, an incomplete conventional process-type LCA of two alternative options can result in preferences and recommendations to decision makers that are different from preferences and recommendations concluded from a complete hybrid input-output-based assessment. Therefore, the need to avoid misleading effects on the ranking of alternative functional units due to differential convergence supports the practice of hybrid input-output-based LCA techniques. 相似文献
122.
Unequal divisions at the third cleavage increase the number of primary mesenchyme cells in sea urchin embryos 总被引:3,自引:3,他引:0
To clarify the distribution and behavior of the maternal factors that direct the differentiation of primary mesenchyme cells (PMC) in sea urchin embryos, unequal division was induced at the third cleavage with the treatment of dinitro-phenol (DNP), and the numbers of differentiated PMC were examined. The most surprising finding was that the number of PMC was considerably increased in some of the DNP-treated embryos. This increase in the number of PMC was suggested to be closely related to the size of the precocious micromeres formed at the 8-cell stage. By measuring both the size of the precocious micromeres and the number of PMC in individual embryos, it was suggested that almost all the descendants of the precocious micromeres differentiated into PMC, if the volume was less than 26 pL (about three times the volume of normal micromeres). Cell tracing experiments ascertained that precocious micromeres with small volumes behave just like micromeres formed at the fourth cleavage in normal embryos. The obtained results indicated that the maternal factors present in sea urchin embryos can direct, at least, more than three times the number of PMC, and that the number of cell divisions of the PMC lineage is not strictly regulated. 相似文献
123.
Summary A Monte Carlo-type simulation of the evolution of a multigene family was performed. The model was designed to study the selective forces which may control the size of a multigene family. As expected, we find that direct selection on the size of the multigene family can control its size. More important, we find that selection acting upon the family as a single functional unit, in conjunction with homologous but unequal crossing over, can also control the size of a multigene family. 相似文献
124.
Sevgin Demirci Sander A. Peters Dick de Ridder Aalt D.J. van Dijk 《The Plant journal : for cell and molecular biology》2018,95(4):686-699
A better understanding of genomic features influencing the location of meiotic crossovers (CO s) in plant species is both of fundamental importance and of practical relevance for plant breeding. Using CO positions with sufficiently high resolution from four plant species [Arabidopsis thaliana , Solanum lycopersicum (tomato), Zea mays (maize) and Oryza sativa (rice)] we have trained machine‐learning models to predict the susceptibility to CO formation. Our results show that CO occurrence within various plant genomes can be predicted by DNA sequence and shape features. Several features related to genome content and to genomic accessibility were consistently either positively or negatively related to CO s in all four species. Other features were found as predictive only in specific species. Gene annotation‐related features were especially predictive for maize, whereas in tomato and Arabidopsis propeller twist and helical twist (DNA shape features) and AT /TA dinucleotides were found to be the most important. In rice, high roll (another DNA shape feature) and low CA dinucleotide frequency in particular were found to be associated with CO occurrence. The accuracy of our models was sufficient for Arabidopsis and rice (area under receiver operating characteristic curve, AUROC > 0.5), and was high for tomato and maize (AUROC ? 0.5), demonstrating that DNA sequence and shape are predictive for meiotic CO s throughout the plant kingdom. 相似文献
125.
Effect of different salt ions on the propensity of aggregation and on the structure of Alzheimer's abeta(1-40) amyloid fibrils 总被引:1,自引:0,他引:1
Klement K Wieligmann K Meinhardt J Hortschansky P Richter W Fändrich M 《Journal of molecular biology》2007,373(5):1321-1333
The formation of amyloid fibrils and other polypeptide aggregates depends strongly on the physico-chemical environment. One such factor affecting aggregation is the presence and concentration of salt ions. We have examined the effects of salt ions on the aggregation propensity of Alzheimer's Abeta(1-40) peptide and on the structure of the dissolved and of the fibrillar peptide. All salts examined promote aggregation strongly. The most pronounced effect is seen within the cationic series, i.e. for MgCl2. Evaluation of different possible explanations suggests that Abeta(1-40) aggregation depends on direct interaction between ions and Abeta(1-40) peptide, and correlates with ion-induced changes of the surface tension. Salts have profound effects on the fibril structure. In the presence of salts, fibrils are associated with smaller diameters, narrower crossover distances and lower amide I maxima. Since Abeta(1-40) aggregation responds to salts in a manner unlike that for other polypeptides, such as glucagon, beta2-microglobulin or alpha-synuclein; these data argue that there is no fully uniform way in which salts affect aggregation of different polypeptide chains. These observations are important for understanding and predicting aggregation on the basis of simple physico-chemical properties. 相似文献
126.
In Escherichia coli, RecBCD processes double-stranded DNA breaks during the initial stages of homologous recombination. RecBCD contains helicase and nuclease activities, and unwinds and digests the blunt-ended DNA until a specific eight-nucleotide sequence, Chi, is encountered. Chi modulates the nuclease activity of RecBCD and results in a resected DNA end, which is a substrate for RecA during subsequent steps in recombination. RecBCD also acts as a defence mechanism against bacteriophage infection by digesting linear viral DNA present during virus replication or resulting from the action of restriction endonucleases. To avoid this fate, bacteriophage lambda encodes the gene Gam whose product is an inhibitor of RecBCD. Gam has been shown to bind to RecBCD and inhibit its helicase and nuclease activities. We show that Gam inhibits RecBCD by preventing it from binding DNA. We have solved the crystal structure of Gam from two different crystal forms. Using the published crystal structure of RecBCD in complex with DNA we suggest models for the molecular mechanism of Gam-mediated inhibition of RecBCD. We also propose that Gam could be a mimetic of single-stranded, and perhaps also double-stranded, DNA. 相似文献
127.
Pasquale Termolino Matthieu Falque Riccardo Aiese Cigliano Gaetana Cremona Rosa Paparo Antoine Ederveen Olivier C. Martin Federica M. Consiglio Clara Conicella 《The Plant journal : for cell and molecular biology》2019,100(6):1163-1175
During meiosis, recombination ensures allelic exchanges through crossovers (COs) between the homologous chromosomes. Advances in our understanding of the rules of COs have come from studies of mutations including structural chromosomal rearrangements that, when heterozygous, are known to impair COs in various organisms. In this work, we investigate the effect of a large heterozygous pericentric inversion on male and female recombination in Arabidopsis. The inversion was discovered in the Atmcc1 mutant background and was characterized through genetic and next‐generation sequencing analysis. Reciprocal backcross populations, each consisting of over 400 individuals, obtained from the mutant and the wild type, both crossed with Landsberg erecta, were analyzed genome‐wide by 143 single‐nucleotide polymorphisms. The negative impact of inversion became evident in terms of CO loss in the rearranged chromosome in both male and female meiosis. No single‐CO event was detected within the inversion, consistent with a post‐meiotic selection operating against unbalanced gametes. Cytological analysis of chiasmata in F1 plants confirmed that COs were reduced in male meiosis in the chromosome with inversion. Crossover suppression on the rearranged chromosome is associated with a significant increase of COs in the other chromosomes, thereby maintaining unchanged the number of COs per cell. The CO pattern observed in our study is consistent with the interchromosomal (IC) effect as first described in Drosophila. In contrast to male meiosis, in female meiosis no IC effect is visible. This may be related to the greater strength of interference that constrains the CO number in excess of the minimum value imposed by CO assurance in Arabidopsis female meiosis. 相似文献
128.
G.D. Ruxton 《Ecology letters》1999,2(1):4-5
A widely studied ecological model considers the distribution of individuals of different competitive abilities between a number of resources, such that each opti-mizes its reward rate. Recently this model has been criticised for making the predic-tion that the reward rate of an individual can increase under some circumstances with increasing competitor number. The originators of the model have challenged the suggestion that this prediction is biologically implausible and challenged empiricists to test this prediction. Here it is shown that a previous study on hares is consistent with the controversial prediction of the original model, but not with that of an alternative formulation. 相似文献
129.
Bennetzen JL 《Genetica》2002,115(1):29-36
Plant genomes are exceptional for their great variation in genome size, an outcome derived primarily from their frequent polyploid origins and from the amplification of retrotransposons. Although most studies of plant genome size variation have focused on developmental or physiological effects of nuclear DNA content that might influence plant fitness, more recent studies have begun to investigate possible mechanisms for plant genome expansion and contraction. Analyses of relatively neutral genome components, like transposable elements, have been particularly fruitful, largely due to the enormous growth in genomic sequence information from many different plant species. Current data suggest that unequal recombination can slow the growth in genome size caused by retrotransposon amplification, but that illegitimate recombination and other deletion processes may be primarily responsible for the removal of non-essential DNA from small genome plants. 相似文献
130.
Nader Hassan Frank Kubel Azzedine Bousseksou Roman Bo?a 《Inorganica chimica acta》2009,362(10):3629-700
Two new 1-(tetrazol-1-yl)cycloalkanes [Cntz] with n = 5 and 6 were synthesised as ligands for iron(II) spin crossover complexes. Just recently, the [Fe(C3tz)6](BF4)2 showed that the rigid cyclopropyl-substituent of the tetrazole yielded a rather abrupt and complete spin transition at T½ ≈ 190 K [1]. Aiming for a deeper insight into the factors governing the spin transition behavior such as abruptness and spin transition temperature we synthesized the two new homologous complexes [Fe(C5tz)6](BF4)2 and [Fe(C6tz)6](BF4)2 which were characterized by XRPD, magnetic susceptibility measurements, DSC, 57Fe-Mössbauer, UV-Vis-NIR and MIR spectroscopy. The magnetic and structural properties of both [Fe(Cntz)6](BF4)2 with n = 5 and 6 are also compared with the [Fe(C3tz)6](BF4)2 and its structural peculiarities are discussed. 相似文献