Prospective parallel randomized trial of the MultiCyte™ ThinPrep® imaging system: the Scottish experience

T.J. Palmer, S.M. Nicoll, M.E. McKean, A.J. Park, D. Bishop, L. Baker and J.E.A. Imrie
Prospective parallel randomized trial of the MultiCyte? ThinPrep^® imaging system: the Scottish experience Background: Computer‐assisted screening of cervical liquid‐based cytology (LBC) preparations using the ThinPrep® Imaging System (TIS) has shown improved qualitative and quantitative gains. The use of Multicyte? has not been described in a well‐established national screening programme with a low incidence of high‐grade dyskaryosis. Objectives: To assess the impact of computer‐assisted screening within the Scottish Cervical Screening Programme (SCSP). Methods: Two groups of three laboratories, each sharing a ThinPrep® Imager, screened 79 366 slides randomized to test and 90 551 to control arms by laboratory accession. Screeners were not blinded. Standard laboratory reporting profiles of the SCSP, sensitivity, specificity and false‐negative rates of all grades of LBC abnormalities with respect to final cytology reports, predictive value for cervical intraepithelial neoplasia grade 2 or worse (CIN2+) on histology; and screening rates were compared for both arms. Results: Inadequate and negative reporting rates were significantly lower and low‐grade reporting rates significantly higher in the imager arm. Imager‐assisted screening showed significantly better specificity than manual screening with respect to the final cytology result. There was no evidence of a significant difference in the detection of CIN2 + or CIN3 + . Positive, abnormal and total predictive values (high‐grade, low‐grade and all abnormal cytology found to be CIN2 + , respectively) were similar in both arms. Productivity was significantly higher in the imager arm. Conclusion: Computer‐assisted screening in a well established screening programme showed significantly improved productivity without loss of quality. These findings should inform future policy for cervical screening programmes.     

土壤有机碳库的关键影响因素及其不确定性

土壤是陆地生态系统最大的有机碳库,比植被碳库或大气碳库的两倍还多。准确评估土壤有机碳库是预测全球变化与土壤有机碳之间反馈关系的关键。但目前对土壤有机碳库的估算还存在很大不确定性。该文综述了土壤有机碳库估算及其影响因素和土壤有机碳库估算不确定性的来源和常用的采样方法,以及计算土壤碳汇的最新研究进展。未来技术进步以及模型的不断完善可能会降低土壤有机碳库估算的不确定性,提高其估算的精度     

Pet Ownership in Childhood and Socio-Emotional Characteristics,Work Values and Professional Choices in Early Adulthood

ABSTRACT

The main goal of this study, partly retrospective in character, was to explore if and how pet ownership in childhood is related to several indicators of socio-emotional development, as well as work values and professional choices in early adulthood. The sample consisted of 356 students (200 females, 156 males) from different colleges of the University of Zagreb, representing helping (n=200) and non-helping (n=156) professions. The mean age of the students was 21 years. Seventy-four percent of the participants had had a pet during childhood, mostly dogs. Participants who had owned a pet during childhood reported quite a strong attachment to it. In addition, pets were rated lower than family members and friends, but higher than television, relatives and neighbors in terms of the social support derived from them during childhood. Discriminant analysis was performed in order to examine whether young adults – those who had owned a pet during childhood and those who hadn't – differed in emotional and motivational characteristics, and whether there was a correlation with their chosen subject of study. Pet ownership in childhood was a grouping variable, while measures of current socio-emotional functioning (empathy, prosocial behavior, social anxiety and loneliness), value orientations (self-actualisation, individualistic, social, utilitarian and adventurous) and chosen subject of study (helping or non-helping profession) were predictors. A significant discriminant function was obtained. Correlations between discriminating variables and discriminant function showed that young adults who had had a pet during childhood were more empathetic, more prone to choose helping professions, and more oriented towards social values than those who did not have a pet during childhood.     

Testing Someone Else’s Intelligence: From Regimentation to Freedom1

This article discusses the trend in the development of testing from maximum regimentation of the test-takers’ activity (where they solve problems clearly formulated by the creator with a single correct answer) to diagnostic problematic situations that are very new and indefinite with an open beginning and an open end. With increasing frequency, the open beginning used in testing presupposes a freedom of independent formulation of one’s own research questions of the reality being studied and a search for answers while interacting with that reality. The emergence of mass testing of exploratory behavior is a reflection of the conviction that one of the key abilities that will be required in the very near future is the ability to cope with uncertainty and novelty, including by actively investigating them.

The discussion deals with the problems of testing intelligence and creativity in conditions of novelty and uncertainty, including the “judging problem.” It is pointed out that any thinking test, especially a test of creative thinking, is also an implicit (albeit perhaps not conscious) claim by its developers that their wisdom is virtually unsurpassed. After all, it is assumed that any person’s intelligence and creativity that unfold in a new situation may be described in the context of the model produced by the creative intellect of the test’s developer and, hence, by a more powerful “superintellect.” The errors that are practically inevitable with such an approach can be corrected in a dialog among various groups of researchers or, to the contrary, may be deepened if criticism is shut off.

The article analyzes a fundamental methodological error of creativity testing—the “standard list of creative answers” drawn up by the test-maker in advance, against which the participants’ solutions are checked. This error is explored in the case of an invention-oriented task in the international scholastic test PISA 2012, based on which the education ratings of countries are constructed.

An optimistic thesis is offered: no matter how successful testing is, humankind will never be fully prepared to determine its creative potential, due to its forward development. Without diagnostic tools, however, it will be far less prepared; they are a new and important part of that potential.     

In the World of Contemporary Design

Assessment is essential to all forms of work in the arts. Successful arts assessment concepts, patterns, and methods have evolved over many centuries. They are inherent in all arts teaching and central to art-making at all levels of proficiency and sophistication. And they work: achievements in the arts are among the highest in civilization. At present, these arts-based systems of assessment are increasingly pursued in a problematic context. Regnant assessment values and systems are often so highly technocratic, so narrowly focused on what can be counted easily, and so prosaically engineered for application on a massive scale that they are incompatible with the nature of arts assessment and regularly discount its value and its results. Means for responding and acting are needed that preserve the fundamental nature of arts teaching and learning. There are ways for those professionally concerned about the arts and arts teaching to reaffirm and rearticulate essential principles of artistic evaluation and, in the present environment, pursue applications of those principles in various forms of evaluation. Reaffirmation, rearticulation, and pursuit must be deeply rooted in an understanding of why these principles are essential for the progress of the arts disciplines and for arts-centered student learning. Such reaffirmation, rethinking, and rearticulation can establish the basis for explaining arts principles, achievements, and methods to others; debating when necessary; and ensuring the preservation of conditions that encourage the effective incorporation of new findings or capabilities in assessment into the ever-evolving assessment and evaluation systems developed by and suitable for the arts in ways that are compatible with their nature and the integrity of their practice.     

Stabilizing selection and adaptive evolution in a combination of two traits in an arctic ungulate

Stabilizing selection is thought to be common in wild populations and act as one of the main evolutionary mechanisms, which constrain phenotypic variation. When multiple traits interact to create a combined phenotype, correlational selection may be an important process driving adaptive evolution. Here, we report on phenotypic selection and evolutionary changes in two natal traits in a semidomestic population of reindeer (Rangifer tarandus) in northern Finland. The population has been closely monitored since 1969, and detailed data have been collected on individuals since they were born. Over the length of the study period (1969–2015), we found directional and stabilizing selection toward a combination of earlier birth date and heavier birth mass with an intermediate optimum along the major axis of the selection surface. In addition, we demonstrate significant changes in mean traits toward earlier birth date and heavier birth mass, with corresponding genetic changes in breeding values during the study period. Our results demonstrate evolutionary changes in a combination of two traits, which agree closely with estimated patterns of phenotypic selection. Knowledge of the selective surface for combinations of genetically correlated traits are vital to predict how population mean phenotypes and fitness are affected when environments change.     

European Electronic Personal Health Records initiatives and vulnerable migrants: A need for greater ethical,legal and social safeguards

The effective collection and management of personal data of rapidly migrating populations is important for ensuring adequate healthcare and monitoring of a displaced peoples’ health status. With developments in ICT data sharing capabilities, electronic personal health records (ePHRs) are increasingly replacing less transportable paper records. ePHRs offer further advantages of improving accuracy and completeness of information and seem tailored for rapidly displaced and mobile populations. Various emerging initiatives in Europe are seeking to develop migrant‐centric ePHR responses. This paper highlights their importance and benefits, but also identifies a number of significant ethical, legal and social issues (ELSI) and challenges to their design and implementation, regarding (1) the kind of information that should be stored, (2) who should have access to information, and (3) potential misuse of information. These challenges need to be urgently addressed to make possible the beneficial use of ePHRs for vulnerable migrants in Europe.     

基于土地利用变化的粤港澳大湾区生态系统服务价值预测研究

基于粤港澳大湾区2000、2005、2010和2015四个时期的遥感影像, 通过马尔科夫链预测其2025年的土地利用结构, 评估该时期区域的生态系统服务价值及其变化特征, 揭示出区域城市化进展对生态系统服务价值的影响。结果表明: 2000-2015年间, 研究区内的林地、水域、耕地面积逐渐减少, 而城镇建设用地迅速增长的同时挤压了其他地类空间, 在时间序列2010-2015年更为明显, 说明此现象并未得到有效遏制。根据预测的结果, 2025年城镇建设用地达到11387.10 km2, 但生态系统服务价值整体减少755.98亿元。