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981.
Strong invaders are strong defenders – implications for the resistance of invaded communities
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Anna Henriksson David A. Wardle Johan Trygg Sebastian Diehl Göran Englund 《Ecology letters》2016,19(4):487-494
Many ecosystems receive a steady stream of non‐native species. How biotic resistance develops over time in these ecosystems will depend on how established invaders contribute to subsequent resistance. If invasion success and defence capacity (i.e. contribution to resistance) are correlated, then community resistance should increase as species accumulate. If successful invaders also cause most impact (through replacing native species with low defence capacity) then the effect will be even stronger. If successful invaders instead have weak defence capacity or even facilitative attributes, then resistance should decrease with time, as proposed by the invasional meltdown hypothesis. We analysed 1157 introductions of freshwater fish in Swedish lakes and found that species’ invasion success was positively correlated with their defence capacity and impact, suggesting that these communities will develop stronger resistance over time. These insights can be used to identify scenarios where invading species are expected to cause large impact. 相似文献
982.
Species roles in ecological networks combine to generate their architecture, which contributes to their stability. Species trait diversity also affects ecosystem functioning and resilience, yet it remains unknown whether species’ contributions to functional diversity relate to their network roles. Here, we use 21 empirical pollen transport networks to characterise this relationship. We found that, apart from a few abundant species, pollinators with original traits either had few interaction partners or interacted most frequently with a subset of these partners. This suggests that narrowing of interactions to a subset of the plant community accompanies pollinator niche specialisation, congruent with our hypothesised trade‐off between having unique traits vs. being able to interact with many mutualist partners. Conversely, these effects were not detected in plants, potentially because key aspects of their flowering traits are conserved at a family level. Relating functional and network roles can provide further insight into mechanisms underlying ecosystem functioning. 相似文献
983.
984.
Assessing hydrologic alteration: Evaluation of different alternatives according to data availability
The natural flow regime of rivers across the world has been largely modified. Understanding the extent to which the flow regime deviates from natural conditions is necessary for designing sound management and restoration measures. In this regard, ‘Indicators of Hydrologic Alteration’ is currently considered one of the most effective approaches for assessing hydrologic alteration (HA). However, several generalized drawbacks such as the climatic variability between the pre- and post-impacted series and the scarcity of hydrological data in many impaired rivers should be addressed. In this study, a protocol with the following five alternative designs based on data availability is presented: (1) Paired-Before–After Control–Impact (BACIP), (2) Before–After (BA), (3) Control–Impact (CI), (4) Hydrological Classification (HC) and (5) Predicted Hydrological indices (HP). BACIP compares the status of the impacted gauge before and after the perturbation is started, in addition to controlling for natural climatic changes. Hence, it has been considered as the reference benchmark for all other designs. When this protocol was applied to 11 reservoirs situated in the northern third of the Iberian Peninsula, the BA design was able to correctly identify most of the non-significant HA but failed in almost one quarter of the significant alterations. Similarly, BACIP and CI showed an agreement of >80%. This suggests that the method is suitable when proper data are unavailable for BACIP or BA. In addition, our results indicated that the critical thresholds for HA varied depending on the hydrological index being considered. Significant HAs ranged from <5% for the number of days with increasing and decreasing flows to >64% for the duration of low-flow pulses. To delineate adequate thresholds, further research combining hydrological analyses with the biological response to the HA is warranted. Finally, the application of HC and HP designs revealed a significant degree of uncertainty related to the intra-class variability and the predictive error of the models. Therefore, 25% of the analysis could not be evaluated. However, in the evaluable cases, the HC and HP designs correctly assessed >75% of the HA, which highlighted the potential of this method in cases of scarce streamflow data. 相似文献
985.
As the largest CO2 emitter in the world, China has faced great pressure to mitigate its CO2 emissions. Thus, issues related to CO2 emissions in China have been widely studied. However, the industrial linkages of CO2 emissions at the regional level have been less concerned. This study integrates hypothetical extraction method with the multi-regional input–output model, and investigates industrial CO2 emission linkages of China at the regional level. Based on the data of China in 2007, which decomposes China into eight regions, this study first analyzes the production-based emission (PBE) and consumption-based emission (CBE) of each region. The PBE and CBE of 10 branches are then analyzed and decomposed into three parts. Finally, this study decomposes the externally produced embodied emission (EPEE) and internally produced embodied emission (IPEE) of Petrochemicals and Minerals in the East Coast, to illustrate how these two indicators of a branch affect other branches in the economy. Results show that regions with large PBE, such as coastal regions and Central, usually have large CBE, whereas Jing-jin has the smallest PBE and CBE. Branches such as Mining and Petrochemicals and Minerals, have large PBE and are net CO2 emission exporters; while Construction and Other Services are net importers. According to the decomposition results of PBE and CBE, branches can be classified into four groups. The decomposed IPEE and EPEE of Petrochemicals and Minerals in the East Coast show that from the perspective of regions, CO2 emissions this branch exports to and imports from East Coast are most. From the perspective of branches, decomposition of IPEE shows that Petrochemicals and Minerals in the East Coast exports a large amount of CO2 emissions to Construction, while the decomposition results of EPEE show that the studied branch imports least CO2 emissions from Construction. Policy implications deduced from this study are discussed. 相似文献
986.
Johanna Szabó Ildikó Bacsa János Wölfling Gyula Schneider István Zupkó Mónika Varga 《Journal of enzyme inhibition and medicinal chemistry》2016,31(4):574-579
An efficient synthesis of several N-[(1-benzyl-1,2,3-triazol-4-yl)methyl]carboxamides in the 13β- and 13α-d-secoestrone series is reported. Novel triazoles were synthesized via the Cu(I)-catalyzed azide–alkyne cycloaddition of steroidal alkynyl carboxamides and p-substituted benzyl azides. Each of the products was evaluated in vitro by means of MTT assays for antiproliferative activity against a panel of human adherent cancer cell lines (HeLa, MCF-7, A431 and A2780). Some of them exhibited activities similar to those of the reference agent cisplatin. On change of the substitution pattern of the benzyl group of the azide, great differences in the cell growth-inhibitory properties were observed. The p-alkylbenzyl-substituted triazoles selectively exerted high cytostatic action against A2780 cells, with IC50 values of 1?µM. We investigated the potential inhibitory action exerted on the human 17β-HSD1 activity of the new secosteroids. Three triazoles effectively suppressed the estrone to 17β-estradiol conversion with IC50 values in low micromolar range. 相似文献
987.
Marcello Locatelli Roberta Cifelli Giuseppe Carlucci Annalisa Romagnoli 《Journal of enzyme inhibition and medicinal chemistry》2016,31(1):106-111
A new and specific HPLC–DAD method for the direct determination of Prulifloxacin and its active metabolite, Ulifloxacin, in human plasma has been developed. Plasma samples were analysed after a simple solid phase extraction (SPE) clean-up using a new HILIC stationary phase based high-performance liquid chromatography (HPLC) column and an ammonium acetate buffer (5?mM, pH 5.8)/acetonitrile (both with 1% Et3N, v/v) mobile phase in isocratic elution mode, with Danofloxacin as the internal standard. Detection was performed using DAD from 200 to 500?nm and quantitative analyses were carried out at 278?nm. The LOQ of the method was 1?μg/mL of the cited analytes and the calibration curve showed a good linearity up to 25?μg/mL. For both analytes the precision (RSD%) and the trueness (bias%) of the method fulfil with International Guidelines. The method was applied for stability studies, at three QC concentration levels, in human plasma samples stored at different temperature of?+?25,?+?4 and ?20?°C in order to evaluate plasma stability profiles. 相似文献
988.
Agata Paneth Barbara Kaproń Dominika Hagel Urszula Kosikowska Edyta Kuśmierz 《Journal of enzyme inhibition and medicinal chemistry》2016,31(3):434-440
Twelve 4-benzoyl-1-dichlorobenzoylthiosemicarbazides have been tested as potential antibacterials. All the compounds had MICs between 0.49 and 15.63?µg/ml toward Micrococcus luteus, Bacillus cereus, Bacillus subtilis and Staphylococcus epidermidis indicating, in most cases, equipotent or even more effective action than cefuroxime. In order to clarify if the observed antibacterial effects are universal, further research were undertaken to test inhibitory potency of two most potent compounds 3 and 11 on clinical isolates of Staphylococcus aureus. Compound 11 inhibited the growth of methicillin-sensitive S. aureus (MSSA) at MICs of 1.95–7.81?µg/ml, methicillin-resistant S. aureus (MRSA) at MICs of 0.49–1.95?µg/ml and MDR–MRSA at MIC of 0.98 and 3.90?µg/ml, respectively. Finally, inhibitory efficacy of 3 and 11 on planktonic cells and biofilms formation in clinical isolates of S. aureus and Haemophilus parainfluenzae was tested. The majority of cells in biofilm populations of MSSA and MRSA were eradicated at low level of 3, with MBICs in the range of 7.82–15.63?µg/ml. 相似文献
989.
Haoran Liu Haoqun Fan Xiaohui Gao Xueqing Huang Xianjun Liu Linbo Liu 《Journal of enzyme inhibition and medicinal chemistry》2016,31(4):580-589
In order to study the structure–activity relationship of Flavokawain B Mannich-based derivatives as acetylcholinesterase (AChE) inhibitors in our recent investigation, 20 new nitrogen-containing chalcone derivatives (4?a–8d) were designed, synthesized, and evaluated for AChE inhibitory activity in vitro. The results suggested that amino alkyl side chain of chalcone dramatically influenced the inhibitory activity against AChE. Among them, compound 6c revealed the strongest AChE inhibitory activity (IC50 value: 0.85?μmol/L) and the highest selectivity against AChE over BuChE (ratio: 35.79). Enzyme kinetic study showed that the inhibition mechanism of compound 6c against AChE was a mixed-type inhibition. The molecular docking assay showed that this compound can both bind with the catalytic site and the peripheral site of AChE. 相似文献
990.