通过全景式教学法激发学生学习兴趣的研究——以立克次体为例

立克次体介于细菌和病毒之间、兼具两者特点。课堂教学中,通过讲述中外科学家为科学献身的故事及解决实际问题的经历,国内外郊游、旅行者中立克次体病感染案例,在宠物身上、社区及旅游景点该病的分布,在沿边、沿海、岛屿地区及周边国家该病疫情,在历史上的战争中、当前部队人员中及营房驻地该病的传播情况,力图多维度、多方位、全景式展示立克次体病特点、传播及防控的方方面面,激发学生学习兴趣,提高教学效果。     

Sharing the Knowledge: Sharing Aggregate Genomic Findings with Research Participants in Developing Countries

Returning research results to participants is recognised as an obligation that researchers should always try to fulfil. But can we ascribe the same obligation to researchers who conduct genomics research producing only aggregated findings? And what about genomics research conducted in developing countries? This paper considers Beskow's et al. argument that aggregated findings should also be returned to research participants. This recommendation is examined in the context of genomics research conducted in developing countries. The risks and benefits of attempting such an exercise are identified, and suggestions on ways to avoid some of the challenges are proposed. I argue that disseminating the findings of genomic research to participating communities should be seen as sharing knowledge rather than returning results. Calling the dissemination of aggregate, population level information returning results can be confusing and misleading as participants might expect to receive individual level information. Talking about sharing knowledge is a more appropriate way of expressing and communicating the outcome of population genomic research. Considering the knowledge produced by genomics research a worthwhile output that should be shared with the participants and approaching the exercise as a ‘sharing of knowledge’, could help mitigate the risks of unrealistic expectations and misunderstanding of findings, whilst promoting trusting and long lasting relationships with the participating communities.     

Using statistical equivalence testing in clinical biofeedback research

The technique of statistical equivalence testing is described and recommended for use in clinical biofeedback research. Equivalence testing is valuable in aiding the interpretation of negative results or statistically significant results where effects are small in clinical terms. The method is also useful for establishing the similarity of treatment groups at baseline or for showing that the effect of a potentially confounding variable is tolerably small. Finally, equivalence testing is recommended as a method for documenting the equivalence of biofeedback therapy to proven conventional medical therapies in clinical equivalence trials. Examples, drawn from published literature, are provided.     

A relational database for sequence-specific protein NMR data

Summary A protein NMR database has been designed and is being implemented. The database is intended to contain solution NMR results from proteins and peptides (larger than 12 residues). A relational database format has been chosen that indexes data by: primary journal citation, molecular species, sequence-related and atom-specific assignments, and experimental conditions. At present, all data are entered from the primary refereed literature. Examples are given of sample queries to the database. Possible distribution formats are discussed.