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Blake A. Caldwell Monica Yun Liu Rexxi D. Prasasya Tong Wang Jamie E. DeNizio N. Adrian Leu Nana Yaa A. Amoh Christopher Krapp Yemin Lan Emily J. Shields Roberto Bonasio Christopher J. Lengner Rahul M. Kohli Marisa S. Bartolomei 《Molecular cell》2021,81(4):859-869.e8
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《Cell reports》2023,42(8):112891
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《Cell cycle (Georgetown, Tex.)》2013,12(20):3715-3717
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Jacqueline Severino Moritz Bauer Tom Mattimoe Niccol Arecco Luca Cozzuto Patricia Lorden Norio Hamada Yoshiaki Nosaka So I Nagaoka Pauline Audergon Antonio Tarruell Holger Heyn Katsuhiko Hayashi Mitinori Saitou Bernhard Payer 《The EMBO journal》2022,41(12)
The mammalian germline is characterized by extensive epigenetic reprogramming during its development into functional eggs and sperm. Specifically, the epigenome requires resetting before parental marks can be established and transmitted to the next generation. In the female germline, X‐chromosome inactivation and reactivation are among the most prominent epigenetic reprogramming events, yet very little is known about their kinetics and biological function. Here, we investigate X‐inactivation and reactivation dynamics using a tailor‐made in vitro system of primordial germ cell‐like cell (PGCLC) differentiation from mouse embryonic stem cells. We find that X‐inactivation in PGCLCs in vitro and in germ cell‐competent epiblast cells in vivo is moderate compared to somatic cells, and frequently characterized by escaping genes. X‐inactivation is followed by step‐wise X‐reactivation, which is mostly completed during meiotic prophase I. Furthermore, we find that PGCLCs which fail to undergo X‐inactivation or reactivate too rapidly display impaired meiotic potential. Thus, our data reveal fine‐tuned X‐chromosome remodelling as a critical feature of female germ cell development towards meiosis and oogenesis. 相似文献
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David W. Green Jolanta A. Watson Gregory S. Watson Artemis Stamboulis 《Advanced Biosystems》2020,4(8)
The efficient genesis of pluripotent cells or therapeutic cells for regenerative medicine involves several external manipulations and conditioning protocols, which drives down clinical applicability. Automated programming of the genesis by microscale physical forces and chronological biochemistry can increase clinical success. The design and fabrication of nested polysaccharide droplets (millimeter‐sized) with cell sustaining properties of natural tissues and intrinsic properties for time and space evolution of cell transformation signals between somatic cells, pluripotent cells and differentiated therapeutic cells in a swift and efficient manner without the need for laborious external manipulation are reported. Cells transform between phenotypic states by having single and double nested droplets constituted with extracellular matrix proteins and reprogramming, and differentiation factors infused chronologically across the droplet space. The cell transformation into germ layer cells and bone cells is successfully tested in vitro and in vivo and promotes the formation of new bone tissues. Thus, nested droplets with BMP‐2 loaded guests synthesize mineralized bone tissue plates along the length of a cranial non‐union bone defect at 4 weeks. The advantages of sequenced somatic cell reprogramming and differentiation inside an individual hydrogel module without external manipulation, promoted by formulating tissue mimetic physical, mechanical, and chemical microenvironments are shown. 相似文献