Development and perspectives of scientific services offered by genomic biological resource centres.

A number of fundamental technical developments like the evolvement of oligonucleotide microarrays, new sequencing technologies and gene synthesis have considerably changed the character of genomic biological resource centres in recent years. While genomic biological resource centres traditionally served mainly as providers of sparsely characterized cDNA clones and clone sets, there is nowadays a clear tendency towards well-characterized, high-quality clones. In addition, major new service units like microarray services have developed, which are completely independent of clone collections, reflecting the co-evolution of data generation and technology development. The new technologies require an increasingly higher degree of specialization, data integration and quality standards. Altogether, these developments result in spin-offs of highly specialized biotech companies, some of which will take a prominent position in translational medicine.     

Regulation of dopamine system responsivity and its adaptive and pathological response to stress

Although, historically, the norepinephrine system has attracted the majority of attention in the study of the stress response, the dopamine system has also been consistently implicated. It has long been established that stress plays a crucial role in the pathogenesis of psychiatric disorders. However, the neurobiological mechanisms that mediate the stress response and its effect in psychiatric diseases are not well understood. The dopamine system can play distinct roles in stress and psychiatric disorders. It is hypothesized that, even though the dopamine (DA) system forms the basis for a number of psychiatric disorders, the pathology is likely to originate in the afferent structures that are inducing dysregulation of the DA system. This review explores the current knowledge of afferent modulation of the stress/DA circuitry, and presents recent data focusing on the effect of stress on the DA system and its relevance to psychiatric disorders.     

卫生人力资源对乡镇卫生院服务可及性的影响研究

目的 了解京郊乡镇卫生院卫生服务可及性现状,分析基层卫生人力资源对服务可及性的影响,并提出相应的建议。方法 采用分层抽样与目的抽样结合的方法,对北京市5个远郊区县15个乡镇的21名医务人员以及11名患者进行关键知情人访谈。结果 乡镇卫生院人员队伍不稳定、专业人员缺乏、人员编制有限以及梯队不合理对卫生服务可及性产生直接的影响。结论 从满足人员基本需求、配备专业技术人员、科学制定人员编制以及合理配置人员梯队四方面改善基层卫生人才队伍建设,从而提高卫生服务可及性。     

天津医务人员和患者双向转诊知晓度及意愿性的调查

目的 了解天津市医务人员和患者对社区卫生服务及双向转诊的知晓利用情况;调查医患双方对双向转诊实施的意愿性,分析其影响因素,为顺利实施双向转诊制度提供理论和政策依据。方法 采用目的抽样方法,抽取天津市内六区3家三级医院和8家社区医院的18周岁及以上的医务人员和患者进行问卷调查,整理录入问卷并分析。结果 （1）医患双方对双向转诊的认知度低。（2）科室、职称和工作年限3个因素是医务人员参与双向转诊意向的影响因素。（3）医务人员在进行双向转诊遇到的问题：转诊标准不统一、医疗机构缺乏信息交流、经济利益驱使、医疗保险政策影响、病人不接受。结论 天津市医务人员和患者对社区卫生服务内容、双向转诊知晓情况普遍较低,但是大部分比较赞同开展双向转诊。应加强对双向转诊制度的宣传和医院与社区机构的沟通交流,平衡医疗机构间经济利益,并且坚持以患者为中心,政府在推动医院和社区卫生服务机构双向转诊发展过程中发挥主导作用。     

Hydrological responses of a valley‐bottom wetland to land‐use/land‐cover change in a South African catchment: making a case for wetland restoration

Valley‐bottom wetlands are valuable assets as they provide many ecosystem services to mankind. Despite their value, valley‐bottom wetlands are often exploited and land‐use/land‐cover (LULC) change results in trade‐offs in ecosystem services. We coupled physically based hydrological modeling and spatial analysis to examine the effects of LULC change on water‐related ecosystem services in the Kromme catchment: an important water‐providing catchment for the city of Port Elizabeth. LULC scenarios were constructed to match 5 different decades in the last 50 years to explore the potential effects of restoring the catchment to different historic benchmarks. In the Kromme catchment, valley‐bottom wetlands have declined by 84%, driven by key LULC changes: an increase in irrigated land (307 ha) and invasion by alien trees (336 ha). If the wetlands were restored to the relatively pristine extent and condition of the 1950s, riverflow could increase by approximately 1.13 million m³/a, about 6% of the current supply to Port Elizabeth. Wetland restoration would also significantly improve the catchment's ability to absorb extreme rainfall events, decreasing flood damage. We conclude that in the face of the water scarcity in this region, all ecosystem services, particularly those related to water flow regulation, should be taken into account by decision makers in charge of land zonation. Zonation decisions should not continue to be made on the basis of provisioning ecosystem services alone (i.e. food provision or dam yield). We recommend prioritization of the preservation and restoration of valley‐bottom wetlands providing water‐related ecosystem services to settlements downstream.     

Understory vegetation as an indicator for floodplain forest restoration in the Mississippi River Alluvial Valley,U.S.A.

In the Mississippi River Alluvial Valley (MAV), complete alteration of river‐floodplain hydrology allowed for widespread conversion of forested bottomlands to intensive agriculture, resulting in nearly 80% forest loss. Governmental programs have attempted to restore forest habitat and functions within this altered landscape by the methods of tree planting (afforestation) and local hydrologic enhancement on reclaimed croplands. Early assessments identified factors that influenced whether planting plus tree colonization could establish an overstory community similar to natural bottomland forests. The extent to which afforested sites develop typical understory vegetation has not been evaluated, yet understory composition may be indicative of restored site conditions. As part of a broad study quantifying the ecosystem services gained from restoration efforts, understory vegetation was compared between 37 afforested sites and 26 mature forest sites. Differences in vegetation attributes for species growth forms, wetland indicator classes, and native status were tested with univariate analyses; floristic composition data were analyzed by multivariate techniques. Understory vegetation of restoration sites was generally hydrophytic, but species composition differed from that of mature bottomland forest because of young successional age and differing responses of plant growth forms. Attribute and floristic variation among restoration sites was related to variation in canopy development and local wetness conditions, which in turn reflected both intrinsic site features and outcomes of restoration practices. Thus, understory vegetation is a useful indicator of functional progress in floodplain forest restoration.     

Effects of climate change on the delivery of soil‐mediated ecosystem services within the primary sector in temperate ecosystems: a review and New Zealand case study

Future human well‐being under climate change depends on the ongoing delivery of food, fibre and wood from the land‐based primary sector. The ability to deliver these provisioning services depends on soil‐based ecosystem services (e.g. carbon, nutrient and water cycling and storage), yet we lack an in‐depth understanding of the likely response of soil‐based ecosystem services to climate change. We review the current knowledge on this topic for temperate ecosystems, focusing on mechanisms that are likely to underpin differences in climate change responses between four primary sector systems: cropping, intensive grazing, extensive grazing and plantation forestry. We then illustrate how our findings can be applied to assess service delivery under climate change in a specific region, using New Zealand as an example system. Differences in the climate change responses of carbon and nutrient‐related services between systems will largely be driven by whether they are reliant on externally added or internally cycled nutrients, the extent to which plant communities could influence responses, and variation in vulnerability to erosion. The ability of soils to regulate water under climate change will mostly be driven by changes in rainfall, but can be influenced by different primary sector systems' vulnerability to soil water repellency and differences in evapotranspiration rates. These changes in regulating services resulted in different potentials for increased biomass production across systems, with intensively managed systems being the most likely to benefit from climate change. Quantitative prediction of net effects of climate change on soil ecosystem services remains a challenge, in part due to knowledge gaps, but also due to the complex interactions between different aspects of climate change. Despite this challenge, it is critical to gain the information required to make such predictions as robust as possible given the fundamental role of soils in supporting human well‐being.     

Keystone resources available to wild pollinators in a winter‐flowering tree crop plantation

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Impacts of forest cover change on ecosystem services in high Andean mountains

Land conversion affects the delivery of ecosystem goods and services. In this study, we used a 50 years time series of land cover maps to assess the potential impacts of forest cover changes on ecosystem services. A multi-source data integration strategy was followed to reduce inconsistencies in land cover change detection that result from the comparison of historical aerial photographs and satellite images. Our forest cover change analysis highlighted a shift from net deforestation to net reforestation in the early 1990s, consistent with the forest transition theory. When taking the nature of forest cover changes into account, our data show that the areal increase of the forested area was not associated with an improvement in ecological conditions. The overall capacity of the landscape to deliver ecosystem services dropped steadily by 16% over the 50 years’ study period. Conversion of native forests to agricultural land was associated with the strongest decline in ecosystem services. Conversion of natural grasslands into pine plantations mostly led to negative and probably irreversible impacts on the delivery of ecosystem services. Conversion of degraded agricultural lands into pine plantations led to an improvement in ecological conditions. An effective spatial targeting of forestation programs has the potential to maximize the environmental benefits that forest plantations may offer while minimizing their environmental harm.