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231.
232.
Miloslav Vobecky Arnoŝt Babicky Jaroslav Lener 《Biological trace element research》1996,55(3):215-219
The time course of iodine excretion in adult male rats substantially differs from bromine excretion. Bromine is excreted at
a single rate, whereas iodine evinces two excretion rates. Even a strong increase in bromide intake in experimental animals
failed to affect the rate of iodine excretion but it lowered the fraction of iodine accumulated increase in bromide intake
in experimental animals failed to affect the rate of iodine excretion but it lowered the fraction of iodine accumulated in
the thyroid gland by 20% probably by affecting the transport of iodide into the thyroid gland. 相似文献
233.
Jeyeon Lee Jin Ook Chung Seon-Young Park Naveen Rajamohan Aparna Singh JungJin Kim Val J. Lowe SeungBaek Lee 《Biochemistry and Biophysics Reports》2022
Diabetes from pancreatic β cell death and insulin resistance is a serious metabolic disease in the world. Although the overproduction of mitochondrial reactive oxygen species (ROS) plays an important role in the pathogenesis of diabetes, its specific molecular mechanism remains unclear. Here, we show that the natural Charisma of Aqua (COA) water plays a role in Streptozotocin (STZ) diabetic stress-induced cell death inhibition. STZ induces mitochondrial ROS by increasing Polo-like kinase 3 (Plk3), a major mitotic regulator, in both Beta TC-6 and Beta TC-tet mouse islet cells and leads to apoptosis. Overexpression of Plk3 regulates an increase in mitochondrial ROS as well as cell death, also these events were inhibited by Plk3 gene knockdown in STZ diabetic stimulated-Beta TC-6 cells. Interestingly, we found that natural COA water blocks mitochondrial ROS generation through the reduction of Plk3 and prevents apoptosis in STZ-treated beta cells. Furthermore, using the 3D organoid (ex vivo) system, we confirmed that the insulin secretion of the supernatant medium under STZ treated pancreatic β-cells is protected by the natural COA water. These findings demonstrate that the natural water COA has a beneficial role in maintaining β cell function through the inhibition of mitochondrial ROS-mediated cell death, and it might be introduced as a potential insulin stabilizer. 相似文献
234.
《Molecular cell》2023,83(10):1623-1639.e8
235.
CD82, which was originally referred to as KAI1 (kangai 1), is a member of the tetraspanin protein family, which contains four transmembrane domains. CD82 is implicated in a variety of biological processes, including apoptosis, cell adhesion, and cell migration. In this study, the full-length cDNA of pig CD82 was cloned and sequenced. Pig Cd82 cDNA contains an open reading frame (801 bp) encoding 266 amino acids. Sequence alignment results indicated that pig CD82 cDNA evidenced 85.45%, 85.63%, 77.03%, and 77.78% identity with human, cattle, rat, and mouse, respectively. In the expression study, the constitutive expression of swine Cd82 mRNA was detected in a variety of tissues, including lymphoid tissues as well as nonlymphoid tissues. Future studies will be focused on the functional role of CD82 during the course of pig infectious diseases or tumor development. 相似文献
236.
Published in 2004.
This revised version was published online in August 2006 with corrections to the Cover Date. 相似文献
237.
238.
Superoxide dismutases (SODs) are metalloproteins that protect cells against oxidative stress by controlling the concentration of superoxide (O2−) through catalysis of its dismutation. The activity of superoxide dismutases can be mimicked by low-molecular-weight complexes having potential therapeutic applications. This review presents recent strategies for designing efficient SOD mimics, from molecular metal complexes to nanomaterials. Studies of these systems in cells reveal that some SOD mimics, designed to react directly with superoxide, may also indirectly enhance the cellular antioxidant arsenal. Finally, a good understanding of the bioactivity requires information on the cell-penetration, speciation, and subcellular location of the SOD mimics: we will describe recent studies and new techniques that open opportunities for characterizing SOD mimics in biological environments. 相似文献
239.
240.
Erin B.D. Clabough 《The Yale journal of biology and medicine》2013,86(2):217-233
Huntington’s disease (HD) is an autosomal dominant genetic disorder that
specifically causes neurodegeneration of striatal neurons, resulting in a triad
of symptoms that includes emotional, cognitive, and motor disturbances. The HD
mutation causes a polyglutamine repeat expansion within the N-terminal of the
huntingtin (Htt) protein. This expansion causes aggregate formation within the
cytosol and nucleus due to the presence of misfolded mutant Htt, as well as
altered interactions with Htt’s multiple binding partners, and changes in
post-translational Htt modifications. The present review charts efforts toward a
therapy that delays age of onset or slows symptom progression in patients
affected by HD, as there is currently no effective treatment. Although silencing
Htt expression appears promising as a disease modifying treatment, it should be
attempted with caution in light of Htt’s essential roles in neural maintenance
and development. Other therapeutic targets include those that boost aggregate
dissolution, target excitotoxicity and metabolic issues, and supplement growth
factors. 相似文献