全文获取类型
收费全文 | 6676篇 |
免费 | 644篇 |
国内免费 | 266篇 |
出版年
2024年 | 21篇 |
2023年 | 187篇 |
2022年 | 269篇 |
2021年 | 395篇 |
2020年 | 378篇 |
2019年 | 599篇 |
2018年 | 440篇 |
2017年 | 247篇 |
2016年 | 270篇 |
2015年 | 411篇 |
2014年 | 481篇 |
2013年 | 623篇 |
2012年 | 316篇 |
2011年 | 366篇 |
2010年 | 255篇 |
2009年 | 335篇 |
2008年 | 283篇 |
2007年 | 290篇 |
2006年 | 277篇 |
2005年 | 218篇 |
2004年 | 196篇 |
2003年 | 170篇 |
2002年 | 149篇 |
2001年 | 93篇 |
2000年 | 77篇 |
1999年 | 56篇 |
1998年 | 51篇 |
1997年 | 30篇 |
1996年 | 25篇 |
1995年 | 14篇 |
1994年 | 13篇 |
1993年 | 17篇 |
1992年 | 7篇 |
1991年 | 5篇 |
1990年 | 2篇 |
1989年 | 4篇 |
1988年 | 4篇 |
1987年 | 3篇 |
1986年 | 1篇 |
1985年 | 3篇 |
1984年 | 2篇 |
1980年 | 1篇 |
1979年 | 2篇 |
排序方式: 共有7586条查询结果,搜索用时 46 毫秒
991.
992.
993.
994.
Nuclear lipid mediators: Role of nuclear sphingolipids and sphingosine‐1‐phosphate signaling in epigenetic regulation of inflammation and gene expression
下载免费PDF全文
![点击此处可从《Journal of cellular biochemistry》网站下载免费的PDF全文](/ch/ext_images/free.gif)
995.
Atahar Husein Azfar Jamal Mohammad Zulfazal Ahmed Mohammad Arish Rahat Ali Shams Tabrez Fayyaz Rasool Abdur Rub 《Journal of cellular biochemistry》2018,119(9):7844-7854
Leishmania is a protozoan parasite that resides and replicates in macrophages and causes leishmaniasis. The parasite alters the signaling cascade in host macrophages and evades the host machinery. Small G‐proteins are GTPases, grouped in 5 different families that play a crucial role in the regulation of cell proliferation, cell survival, apoptosis, intracellular trafficking, and transport. In particular, the Ras family of small G‐proteins has been identified to play a significant role in the cellular functions mentioned before. Here, we studied the differential expression of the most important small G‐proteins during Leishmania infection. We found major changes in the expression of different isoforms of Ras, mainly in N‐Ras. We observed that Leishmania donovani infection led to enhanced N‐Ras expression, whereas it inhibited K‐Ras and H‐Ras expression. Furthermore, an active N‐Ras pull‐down assay showed enhanced N‐Ras activity. L donovani infection also increased extracellular signal–regulated kinase 1/2 phosphorylation and simultaneously decreased p38 phosphorylation. In contrast, pharmacological inhibition of Ras led to reduction in the phosphorylation of extracellular signal–regulated kinase 1/2 and enhanced the phosphorylation of p38 in Leishmania‐infected cells, which could lead to increased interleukin‐12 expression and decreased interleukin‐10 expression. Indeed, farnesylthiosalicyclic acid (a Ras inhibitor), when used at the effective level in L donovani–infected macrophages, reduced amastigotes in the host macrophages. Thus, upregulated N‐Ras expression during L donovani infection could be a novel immune evasion strategy of Leishmania and would be a potential target for antileishmanial immunotherapy. 相似文献
996.
MicroRNA‐339‐3p alleviates inflammation and edema and suppresses pulmonary microvascular endothelial cell apoptosis in mice with severe acute pancreatitis‐associated acute lung injury by regulating Anxa3 via the Akt/mTOR signaling pathway
下载免费PDF全文
![点击此处可从《Journal of cellular biochemistry》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Xing‐Mao Wu Kai‐Qiang Ji Hai‐Yuan Wang Yang Zhao Jia Jia Xiao‐Peng Gao Bin Zang 《Journal of cellular biochemistry》2018,119(8):6704-6714
997.
Regulation of fibroblast growth factor 8 (FGF8) in chicken embryonic stem cells differentiation into spermatogonial stem cells
下载免费PDF全文
![点击此处可从《Journal of cellular biochemistry》网站下载免费的PDF全文](/ch/ext_images/free.gif)
998.
Bisphenol A (BPA; 4,4′-isopropylidenediphenol) is an endocrine disruptor that is used as a material for the production of phenol resins, polyacrylates, polyesters, epoxy resins, and polycarbonate plastics. Endocrine-disruptive or toxic effects of BPA on living organisms through a number of cell signaling pathways have been reported. BPA induces carcinogenesis, reproductive toxicity, abnormal inflammatory or immune response, and developmental disorders of brain or nervous system through various cell signaling pathways. This review considers the literature concerning BPA and its association with cancer-related cell signaling pathways, reproductive toxicity-related cell signaling pathways, inflammatory or immune response-related cell signaling pathways, and brain and nervous system-related cell signaling pathways. 相似文献
999.
1000.