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161.
Host manipulation by parasites in the world of dead-end predators: adaptation to enhance transmission? 总被引:1,自引:0,他引:1
Seppälä O Valtonen ET Benesh DP 《Proceedings. Biological sciences / The Royal Society》2008,275(1643):1611-1615
Trophically transmitted parasites often alter their intermediate host's phenotype, thereby predisposing the hosts to increased predation. This is generally considered a parasite strategy evolved to enhance transmission to the next hosts. However, the adaptive value of host manipulation is not clear as it may be associated with costs, such as increased susceptibility to predators that are unsuitable next hosts for the parasites. We examined the ratio between the benefits and costs of host manipulation for transmission success of Acanthocephalus lucii (Acanthocephala), a parasite that alters the hiding behaviour and pigmentation of its isopod hosts. We experimentally compared the susceptibility of infected and uninfected isopods to predation by perch (Perca fluvialis; definitive host of the parasite) and dragonfly larvae (dead end). We found that the parasite predisposed the isopods to predation by both predators. However, the increased predation vulnerability of the infected isopods was higher towards perch. This suggests that, despite the costs due to non-host predation, host manipulation may still be advantageous for the parasite. 相似文献
162.
This is the first study of the effects of mother-infant separation (MS) on adolescent behavior of Holtzman (HO) rats. Different rat strains, such as Harlan Sprague-Dawley and HO, share a common origin. However, MS may lead to hypoactive behavioral effects in HO rats because of their greater susceptibility to show depressive-like responses to stress. Sixty HO pups were divided into three groups at postnatal day 2 (P2). For 10 days, the MS group was separated 6h daily and the early handled (EH) group 15 min daily. A standard facility reared (SFR) group was not separated. Animals were tested for novel open-field activity (P28), defensive withdrawal in a light-dark (LD) apparatus (P29) and familiar open-field (P30). Behavioral measures were classified into general activity (ambulatory and short movement time), orienting (rearing time) and risk-taking (velocity and exposed zone time). MS rats displayed reductions in general activity and risk-taking, and increases in orienting time. In contrast, EH favored risk-taking behavior, which may be consistent with previous findings implicating early handling as beneficial in coping with stress. Sex differences in these behaviors were limited. This study suggests a genetic predisposition in HO rats for predominantly hypoactive/anxiety-like behaviors when exposed to an early life stressor. 相似文献
163.
Menkes syndrome is an X-linked, fatal neurodegenerative disorder of copper metabolism, caused by mutations in the ATP7A gene, encoding a copper-transporting P1B-type ATPase. To date, a total of approximately 160 different mutations have been reported worldwide. The clinical phenotypes observed in these patients include progressive neuro-degeneration, connective-tissue abnormalities and peculiar hair. There is phenotypic variability. While the majority of the patients do not survive early childhood, milder cases leading to longer survival have been reported. In this review we focus on mutations, identified in patients with milder forms of Menkes disease, and discuss the possibility of establishing a genotype–phenotype correlation. The presence of small amounts of normal protein, or the presence of partly functional protein variants containing a less essential amino acid substitution or a truncation of the N- or C-terminus, might all result in a milder, atypical phenotype. A clear phenotype–genotype correlation is however difficult to establish, clearly illustrated by the presence of inter- and even intra-familial variability. 相似文献
164.
Nils Roll-Hansen 《Journal of the history of biology》2009,42(3):457-493
This paper describes the historical background and early formation of Wilhelm Johannsen’s distinction between genotype and
phenotype. It is argued that contrary to a widely accepted interpretation (For instance, W. Provine, 1971. The Origins of Theoretical Population Genetics. Chicago: The University of Chicago Press; Mayr, 1973; F. B. Churchill, 1974. Journal of the History of Biology 7: 5–30; E. Mayr, 1982. The Growth of Biological Thought, Cambridge: Harvard University Press; J. Sapp, 2003. Genesis. The Evolution of Biology. New York: Oxford University Press) his concepts referred primarily to properties of individual organisms and not to statistical
averages. Johannsen’s concept of genotype was derived from the idea of species in the tradition of biological systematics
from Linnaeus to de Vries: An individual belonged to a group – species, subspecies, elementary species – by representing a
certain underlying type (S. Müller-Wille and V. Orel, 2007. Annals of Science 64: 171–215). Johannsen sharpened this idea theoretically in the light of recent biological discoveries, not least those
of cytology. He tested and confirmed it experimentally combining the methods of biometry, as developed by Francis Galton,
with the individual selection method and pedigree analysis, as developed for instance by Louis Vilmorin. The term “genotype”
was introduced in W. Johannsen’s 1909 (Elemente der Exakten Erblichkeitslehre. Jena: Gustav Fischer) treatise, but the idea of a stable underlying biological “type” distinct from observable properties
was the core idea of his classical bean selection experiment published 6 years earlier (W. Johannsen, 1903. Ueber Erblichkeit in Populationen und reinen Linien. Eine Beitrag zur Beleuchtung schwebender Selektionsfragen, Jena: Gustav Fischer, pp. 58–59). The individual ontological foundation of population analysis was a self-evident presupposition
in Johannsen’s studies of heredity in populations from their start in the early 1890s till his death in 1927. The claim that
there was a “substantial but cautious modification of Johannsen’s phenotype–genotype distinction” (Churchill, 1974, p. 24)
from a statistical to an individual ontological perspective derives from a misreading of the 1903 and 1909 texts. The immediate
purpose of this paper is to correct this reading of the 1903 monograph by showing how its problems and results grow out of
Johannsen’s earlier work in heredity and plant breeding. Johannsen presented his famous selection experiment as the culmination
of a line of criticism of orthodox Darwinism by William Bateson, Hugo de Vries, and others (Johannsen, 1903). They had argued
that evolution is based on stepwise rather than continuous change in heredity. Johannsen’s paradigmatic experiment showed
how stepwise variation in heredity could be operationally distinguished from the observable, continuous morphological variation.
To test Galton’s law of partial regression, Johannsen deliberately chose pure lines of self-fertilizing plants, a pure line
being the descendants in successive generations of one single individual. Such a population could be assumed to be highly
homogeneous with respect to hereditary type, and Johannsen found that selection produced no change in this type. Galton, he
explained, had experimented with populations composed of a number of stable hereditary types. The partial regression which
Galton found was simply an effect of selection between types, increasing the proportion of some types at the expense of others. 相似文献
165.
Stylosanthes seabrana (Maass and ‘t Mannetje) (2n = 2x = 20), commonly known as Caatinga stylo, is an important tropical perennial forage legume. In nature, it largely co-exist
with S. scabra, an allotetraploid (2n = 4x = 40) species, sharing a very high similarity for morphological traits like growth habit, perenniality, fruit shape and presence
of small appendage at the base of the pod or loment. This makes the two species difficult to distinguish morphologically,
leading to chances of contamination in respective germplasm collections. In present study, 10 S. seabrana accessions were discovered from the existing global germplasm stock of S. scabra represented by 48 diverse collections, utilizing sequence-tagged-sites (STS) genome-specific markers. All the newly identified
S. seabrana accessions displayed STS phenotypes of typical diploid species. Earlier reports have conclusively indicated S. seabrana and S. viscosa as two diploid progenitors of allotetraploid S. scabra. With primer pairs SHST3F3/R3, all putative S. seabrana yielded single band of ~550 bp and S. viscosa of ~870 bp whereas both of these bands were observed in allotetraploid S. scabra. Since SHST3F3/R3 primer pairs are known to amplify single or no band with diploid and two bands with tetraploid species,
the amplification patterns corroborated that all newly identified S. seabrana lines were diploid in nature. Flow cytometric measurement of DNA content of the species, along with distinguishing morphological
traits such as flowering time and seedling vigour, which significantly differ from S. scabra, confirmed all identified lines as S. seabrana. These newly identified lines exhibited high level of similarity among themselves as revealed by RAPD and STS markers (>92%
and 80% respectively). Along with the enrichment in genetic resources of Stylosanthes, these newly identified and characterized accessions of S. seabrana can be better exploited in breeding programs targeted to quality. 相似文献
166.
Angela M. Zivkovic Michelle M. Wiest UyenThao Nguyen Malin L. Nording Steven M. Watkins J. Bruce German 《Metabolomics : Official journal of the Metabolomic Society》2009,5(2):209-218
The development of assessment techniques with immediate clinical applicability is a priority for resolving the growing epidemic
in metabolic disease. Many imbalances in diet-dependent metabolism are not detectable in the fasted state. Resolving the high
inter-individual variability in response to diet requires the development of techniques that can detect metabolic dysfunction
at the level of the individual. The intra- and inter-individual variation in lipid metabolism in response to a standardized
test meal was determined. Following an overnight fast on three different days, three healthy subjects consumed a test meal
containing 40% of their daily calories. Plasma samples were collected at fasting, and 1, 3, 6, and 8 h after the test meal.
Plasma fatty acid (FA) concentrations within separated lipid classes and lipoprotein fractions were measured at each time
point. The intra-individual variation within each subject across three days was lower than the inter-individual differences
among the three subjects for over 50% of metabolites in the triacylglycerol (TG), FA, and phosphatidylcholine (PC) lipid classes
at 6 h, and for 25–50% of metabolites across lipid classes at 0, 1, 3, and 8 h. The consistency of response within individuals
was visualized by principal component analysis (PCA) and confirmed by ANOVA. Three representative metabolites that discriminated
among the three individuals in the apolipoprotein B (ApoB) fraction, TG16:1n7, TG18:2n6, and PC18:3n3, are discussed in detail.
The postprandial responses of individuals were unique within metabolites that were individual discriminators (ID) of metabolic
phenotype. This study shows that the targeted metabolomic measurement of individual metabolic phenotype in response to a specially
formulated lipid challenge is possible even without lead-in periods, dietary and lifestyle control, or intervention over a
3-month period in healthy free-living individuals. 相似文献
167.
168.
James Patrick Cronin Miranda E. Welsh Martin G. Dekkers Samuel T. Abercrombie Charles E. Mitchell 《Ecology letters》2010,13(10):1221-1232
Control of emerging infectious diseases often hinges on identifying a pathogen reservoir, the source of disease transmission. The potential to function as a pathogen reservoir can be influenced by host lifespan, geographic provenance and phylogeny. Yet, no study has identified factors that causally determine the reservoir potential of diverse host species. We propose the host physiological phenotype hypothesis, which predicts that hosts with short‐lived, poorly defended, nutrient rich and high metabolism tissue have greater values for three epidemiological parameters that determine reservoir potential: host susceptibility to infection, competence to infect vectors and ability to support vector populations. We experimentally tested these predictions using a generalist vectored virus and six wild grass species. Host physiological phenotype explained why hosts differed in all three epidemiological parameters while host lifespan, provenance and phylogeny could not explain host competence. Thus, a single, general axis describing variation in host physiological phenotype may explain reservoir potential. 相似文献
169.
XIANG JI LONG-HUI LIN LAI-GAO LUO HONG-LIANG LU JIAN-FANG GAO JUN HAN 《Biological journal of the Linnean Society. Linnean Society of London》2006,88(3):453-463
We maintained pregnant Sphenomorphus indicus under four thermal conditions for the whole gestation period to assess the effects of gestation temperature on offspring phenotypes. Parturition occurred between late June and early August, with females at high body temperatures giving birth earlier than those maintained at low body temperatures. Litter size, litter mass, and postpartum body mass did not differ among treatments, and females with relatively higher fecundity produced smaller offspring. Females gave birth to predominantly female offspring (85.7% of the 14 sexed offspring were females) at 24 °C and to predominantly male offspring (76.5% of the 17 sexed offspring were males) at 28 °C. Females with the opportunity to regulate body temperature produced a mix of sexes that did not differ from equality. Offspring produced in different treatments differed in head size, hind-limb length, and tympanum length, but not in snout-vent length, tail length, body mass, fore-limb length, and eye length. Offspring produced at 28 °C were not only smaller in head size, but also shorter in hind-limb length and tympanum length than those offspring produced at lower temperatures. Offspring produced at 28 °C performed more poorly in the racetrack and grew more slowly than offspring produced in the other three treatments. Taken together, our results show that S. indicus might be a temperature-dependent sex determination species and that offspring phenotypes are impaired at high gestation temperatures but maximized at relatively low gestation temperatures. © 2006 The Linnean Society of London, Biological Journal of the Linnean Society , 2006, 88 , 453–463. 相似文献
170.
Shihori Tanabe 《World journal of stem cells》2013,5(3):61-67
Cells exhibit a variety of phenotypes in different stages and diseases. Although several markers for cellular phenotypes have been identified, gene combinations denoting cellular phenotypes have not been completely elucidated. Recent advances in gene analysis have revealed that various gene expression patterns are observed in each cell species and status. In this review, the perspectives of gene combinations in cellular phenotype presentation are discussed. Gene expression profiles change during cellular processes, such as cell proliferation, cell differentiation, and cell death. In addition, epigenetic regulation increases the complexity of the gene expression profile. The role of gene combinations and panels of gene combinations in each cellular condition are also discussed. 相似文献