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排序方式: 共有116条查询结果,搜索用时 15 毫秒
111.
Sonya Ruiz-Torres Marion G. Brusadelli David P. Witte Kathryn A. Wikenheiser-Brokamp Sharon Sauter Adam S. Nelson Mathieu Sertorio Timothy M. Chlon Adam Lane Parinda A. Mehta Kasiani C. Myers Mary C. Bedard Bidisha Pal Dorothy M. Supp Paul F. Lambert Kakajan Komurov Melinda Butsch Kovacic Stella M. Davies Susanne I. Wells 《Cell Stem Cell》2021,28(3):424-435.e6
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112.
113.
Y Liu F Lang X Xie S Prabhu J Xu D Sampath K Aldape G Fuller V K Puduvalli 《Cell death & disease》2011,2(2):e121
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis in malignant cells, including gliomas, and is currently in anticancer clinical trials. However, the full-length and tagged forms of TRAIL, unlike the untagged ligand (soluble TRAIL (sTRAIL)), exhibits toxicity against normal cells. Here, we report the generation and testing of an adenovirus (AdsTRAIL) that expresses untagged sTRAIL in an intracranial xenograft model and a human glioma organotypic slice culture model. AdsTRAIL efficiently induced apoptosis in glioma cell lines, including those resistant to sTRAIL, but not in normal human astrocytes (NHAs). It inhibited anchorage-independent glioma growth and exerted a bystander effect in transwell assays. Intratumoral injections of AdsTRAIL in a rodent intracranial glioma model resulted in reduced tumor growth and improved survival compared with Ad-enhanced green fluorescent protein (EGFP)- or vehicle-treated controls without toxicity. Human glioma organotypic slices treated with AdsTRAIL demonstrated apoptosis induction and caspase activation. 相似文献
114.
《Cell Stem Cell》2021,28(11):1907-1921.e8
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115.
Susan Billings-Gagliardi Merrill K. Wolf 《In vitro cellular & developmental biology. Plant》1977,13(6):371-377
Summary This paper describes a method for examination of living organotypic cultures of CNS with Nomarski differential interference-contrast
optics. Cultures grown in Maximow assemblies. which promote the best differentiation of the tissue but are optically faulty,
are transferred for Nomarski observation to a simple sandwich chamber which combines the optical perfection of the usual sandwich
chamber with the flexibility and safeguarding of sterility characteristic of the Maximow assembly. Thus cultures can be transferred
repeatedly between their maintenance and observation chambers. In the resulting microscopic images, it is posible to visualize
delicate unmyelinated fibers, myelinated cell bodies and other features which are normally impossible to demonstrate in living
cultures as well as to improve the images of other structures such as large neuronal perikarya and myelinated axons.
This work was supported in part by NIH Grant NS 11425 相似文献
116.
Kyong Nyon Nam Kyoo‐Pil Kim Ki‐Ho Cho Woo‐Sang Jung Jung‐Mi Park Seung‐Yeon Cho Su‐Kyung Park Tae‐Hoon Park Young‐Suk Kim Eunjoo H. Lee 《Cell biochemistry and function》2013,31(8):707-712
Microglial cells are the prime effectors in immune and inflammatory responses of the central nervous system (CNS). During pathological conditions, the activation of these cells helps restore CNS homeostasis. However, chronic microglial activation endangers neuronal survival through the release of various proinflammatory molecules and neurotoxins. Thus, negative regulators of microglial activation have been considered as potential therapeutic candidates to target neurodegeneration, such as that in Alzheimer's and Parkinson's diseases. The rhizome of Ligusticum chuanxiong Hort. (Ligusticum wallichii Franch) has been widely used for the treatment of vascular diseases in traditional oriental medicine. Butylidenephthalide (BP), a major bioactive component from L. chuanxiong, has been reported to have a variety of pharmacological activities, including vasorelaxant, anti‐anginal, anti‐platelet and anti‐cancer effects. The aim of this study was to examine whether BP represses microglial activation. In rat brain microglia, BP significantly inhibited the lipopolysaccharide (LPS)‐induced production of nitric oxide (NO), tumour necrosis factor‐α and interleukin‐1β. In organotypic hippocampal slice cultures, BP clearly blocked the effect of LPS on hippocampal cell death and inhibited LPS‐induced NO production in culture medium. These results newly suggest that BP provide neuroprotection by reducing the release of various proinflammatory molecules from activated microglia. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献