The Iron Gates Mesolithic – a brief review of recent developments

The Iron Gates section of the Lower Danube valley along the border between Romania and Serbia has an unparalleled record of Mesolithic and Early Neolithic settlement spanning the period from ca. 12,700 to 5600 cal BC. Over 50 cave and open-air sites were identified during archaeological surveys in advance of dam construction in the 1960s and 1980s, and follow-up rescue excavations revealed numerous burials and architectural remains and produced rich inventories of faunal material and portable artifacts including artworks and ornaments of bone, shell and stone. Most sites are no longer accessible, submerged beneath the reservoirs created by the Iron Gates I and II dams. Since 1990, new excavations have been conducted at Aria Babi and Vlasac in Serbia, and Schela Cladovei in Romania, while detailed studies of the finds from both new and old excavations have been undertaken by researchers based in Romania, Serbia and the UK fueled by developments in archaeological science. In this paper, we review the main advances in knowledge of the Mesolithic and the transition to farming in the Iron Gates over the past 25 years, and especially the period since 2005. The paper is divided into sections dealing with chronology, mortuary practices, isotopic studies of subsistence and mobility patterns, and the nature and timing of the transition from Mesolithic to Neolithic in the Iron Gates region. The review concludes with a forward look at research in progress.     

麦红吸浆虫滞育习性研究

1986～1991年研究了麦红吸浆虫的滞育习性,提出了该由主动延长滞育和被动延长滞育的两种形式,探讨了土壤湿度、温度对延长滞育的影响,从体重、羽化率、卵胚数、死亡率等方面测定了延长滞育幼虫的生殖势能,文章最后讨论了麦红吸浆虫多峰羽化的特点和延长滞育的生物学意义。     

Moulin Quignon : la redécouverte d’un site

The collection from Moulin Quignon is a coherent one, despite the diversity of its pieces, in the certainty of its origin, in its attachment to the researches led on the site in 1863–1864. Considered as a historic heritage, its study has nevertheless delivered significant scientific information, valid for the present, and, beyond that, to reintroduce the site of Moulin Quignon in the oldest Palaeolithic panel sites of the Somme valley.     

桉树新害虫——曲线纷夜蛾的生物学和生态特性研究

曲线纷夜蛾Polydesma boarmoides Guenée是我国桉树食叶害虫,已在部分桉树种植区造成严重危害。国内外仅在区域昆虫种类调查中发现并提及该虫,而未见其生物学特性、生态学特性和发生规律等方面的相关研究报道,因此,有必要对该虫进行更系统、深入的研究,为防控该虫提供依据。笔者2013年5月首次发现该虫在广东省紫金县危害桉树林,2016年5月再次发现该虫在茂名市危害桉树林。调查、研究结果表明:(1)曲线纷夜蛾起始取食灌木叶片直至叶片被取食殆尽后,逐步转移至桉树林继续取食桉树叶片;(2)曲线纷夜蛾在广东地区1年发生4代;(3)曲线纷夜蛾3-5龄幼虫在桉树林间呈现聚集分布,且聚集密度呈现随种群密度增大而增大的规律,而在桉树树冠上则呈均匀分布。     

Utilitarian art and art-related objects in the Urals’ Palaeolithic

Stone and bone artefacts serving as expedient food-procurement and processing implements are the principal and most frequent findings at Palaeolithic sites. Utilitarian art items, often aesthetically fashioned artefacts, are much less common. Emergence of cognitive art within the broader Ural region was determined by progressive cultural developments and adaptations of anatomically modern human beings to mosaic mountain settings and parkland-steppes. At the Urals’ Late Pleistocene cave sites, objects, which were made frequently of unusual and rare materials and are presumed to be of a ritual nature, are represented by adornments and artworks bearing stylized pictorial images. Zoomorphic figurines produced from flint and mammoth ivory document the high skills of Stone Age artisans. The earliest, utilitarian, art-related works of the Urals include sculptures using natural pre-forms such as river pebbles and animal bones, occasionally ochre-painted or ornamented by incising or engraving. Personal decorations are represented by pendants and beads made of stone, shell, bone, and teeth of animals. Rare exemplars are made from material of non-local provenance, such as petrified wood or segments of fossil sea-lily (crinoids) and are indicators of a broad geographic activity-range and/or regional interactions among local groups of hunter-gatherers. Artisanal instruments associated with rock art, for example, lamps made from stone and clay as well as pieces of ochre, belong to a specific category. Aesthetic-looking minerals with appealing colours and textures, such as serpentine, rock crystal, chalcedony, and jasper, it may be assumed, were intended for religious or cultic purposes, but also may have been curated simply because of their natural rarity. These art-related items likely had symbolic value and spiritual meaning apart from purely decorative function. Understanding utilitarian art objects offers insights to every-day life of the Palaeolithic people of the Urals, and their behavioural and environmental adjustments, which culminated in multifarious, iconographic expressions at the end of the Last Glacial stage.     

Exemestane metabolites suppress growth of estrogen receptor-positive breast cancer cells by inducing apoptosis and autophagy: A comparative study with Exemestane

Around 60–80% of all breast tumors are estrogen receptor-positive. One of the several therapeutic approaches used for this type of cancers is the use of aromatase inhibitors. Exemestane is a third-generation steroidal aromatase inhibitor that undergoes a complex and extensive metabolism, being catalytically converted into chemically active metabolites. Recently, our group showed that the major exemestane metabolites, 17β-hydroxy-6-methylenandrosta-1,4-dien-3-one and 6-(hydroxymethyl)androsta-1,4,6-triene-3,17-dione, as well as, the intermediary metabolite 6β-Spirooxiranandrosta-1,4-diene-3,17-dione, are potent aromatase inhibitors in breast cancer cells. In this work, in order to better understand the biological mechanisms of exemestane in breast cancer and the effectiveness of its metabolites, it was investigated their effects in sensitive and acquired-resistant estrogen receptor-positive breast cancer cells. Our results indicate that metabolites induced, in sensitive breast cancer cells, cell cycle arrest and apoptosis via mitochondrial pathway, involving caspase-8 activation. Moreover, metabolites also induced autophagy as a promoter mechanism of apoptosis. In addition, it was demonstrated that metabolites can sensitize aromatase inhibitors-resistant cancer cells, by inducing apoptosis. Therefore, this study indicates that exemestane after metabolization originates active metabolites that suppress the growth of sensitive and resistant breast cancer cells. It was also concluded that, in both cell lines, the biological effects of metabolites are different from the ones of exemestane, which suggests that exemestane efficacy in breast cancer treatment may also be dependent on its metabolites.     

艾叶多糖提取率影响因素分析及提取条件优化

艾叶是菊科(Compositae)植物艾(Artemisia argyi Lévl.et Vant.)的干燥叶,为常用中药材之一,药用历史悠久,具有苦燥辛散、理气血、温经脉、逐寒湿、止冷痛等功效,为重要的妇科用药,可用于治疗脘腹冷痛、经寒不调、宫冷不孕等证.此外,利用艾叶预防瘟疫已有悠久的历史.现代药理研究表明:艾叶是一种广谱抗菌抗病毒中药,对多种病毒和细菌有抑制和杀伤作用,对呼吸系统疾病以及心血管等慢性疾病有一定的防治作用[1-3].因此,将艾叶中的有效成分分别提取和纯化并加以分析以及功能检测,具有深远意义.     

L’industrie en calcaire du site Paléolithique d’Isernia la Pineta : un modèle interprétatif de stratégie comportementale

The studies and the researches carried out in the last years on the Palaeolithic site of Isernia La Pineta have brought to consider in new way the activities realized by the human group that lived the basin of Isernia during the Middle Pleistocene offering an important key of interpretation of the behavioural strategies of the prehistoric man. The analysis of the exploitation of the raw material has confirmed the presence on the site of two different lithotypes: flint and limestone; the lithological dichotomy is related to the functional dichotomy of the raw material that seems to have conditioned the activities of the human group in different areas of the site. The necessity to deepen the study on the limestone has derived from the evidence brought to light in the last excavation campaigns of a remarkable concentration of the flaked limestone pebbles and the flake scars in some areas of the explored archeosurfaces, particularly on the 3a and on the overlooking layers. The present study has the purpose to explain the characteristics of the limestone finds both in reference to the raw material and to its state of preservation both to the technotypological evidences and its spatial distribution with the purpose to better understand the modalities of the exploitation of the raw material. The information collected until today have permitted to obtain a precise knowledge of the environmental context and the territorial resources exploited by the human group showing an opportunistic capability to find the most advantageous behavioural solution for the necessities of subsistence.     

Mode de vie à Isernia La Pineta (Molise, Italie). Stratégie d’exploitation du Bison schoetensacki par les groupes humains au Paléolithique inférieur

The site of Isernia La Pineta (Molise, Italie) is characterized by the presence of a rich faunal assemblage related to a very abundant lithic industry in several archaeosurfaces dated between 600,000 and 700,000 BP. A specific archaeozoological study has been carried out on Bison schoetensacki specimens that are the most represented taxon in each archaeological level, followed by rhinoceros, elephant, bear and cervid. The quantitative et qualitative analysis of the faunal remains, the age profiles and the identification of anthropic modifications have allowed to better understand the exploitation strategies adopted by humans in the site and to underline a selective hunting of population of bison, related to the age of the individuals.     

Considérations sur l’extension géographique du Néolithique final à « livre de beurre » en Touraine et Poitou (France)

The “livre de beurre” blades debitage is classically attached to Grand-Pressigny country (Indre-et-Loire). This question is reconsidered by the autors to ligth on their knowledge of the sites and raw materials in a broadest geographic expanse: the South of Touraine and Poitou. Cultural attribution of this practice is also reconsidered and replaced in largest context.