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101.
West Nile virus (WNV) has made considerable impact as an emerging infectious disease, spreading from coast to coast across
North America since 1999. The disease has exhibited great spatial variability in North America, making an ecosystems approach
to understanding the local human and vector ecology critical to prevention and control. This study underscores the importance
of employing both personal prevention and community participatory approaches to create messages that have been adapted to
the local ecology and are designed to reduce the risk of human infection with this mosquito-borne virus. As the virus spreads
into new areas, underlying attitudes toward mosquitoes and the local perception of environment/ecology can affect the success
of control and prevention measures. This work presents results from focus group discussions conducted in two Colorado counties
in 2003, a year of significant WNV activity in the state. Issues addressed include residents’ assessment of risk and how this
perception varied by age group and location, use or nonuse of repellents, and community attitudes toward mosquito control
in areas with different ecologies and histories of mosquito-borne disease. The need to address individual components of personal
prevention, to target prevention to specific audiences, and to disseminate prevention messages through local channels is discussed.
The authors propose including aspects of ecology and disease proximity in understanding risk perception and addressing emerging
diseases with a prominent ecological component. 相似文献
102.
Object exploration is an increasingly popular experimental paradigm in behavioral sciences. We have begun a series of studies with mice specifically looking at the parameters that influence behaviors in this test. The aim of the present study was to examine the effect of object type on performance in the object exploration test. More specifically, adult male C57BL/6J mice were trained and tested using objects that could be climbed (CLIMB) or with those that could only be touched (TOUCH). The results show that activity is affected by the presentation of objects, with object type interacting with some of these changes. C57 mice explored objects that can be climbed over significantly longer than objects that can only be touched and a more rapid habituation was observed using objects that could only be touched. Robust recognition memory was observed in both groups of mice, however mice in the CLIMB group exhibited a significantly greater discrimination index compared to mice in the TOUCH group. Taken together, these findings demonstrate that the selection of objects is of critical importance and it is recommended that special attention be given to the functional (affordant) properties of the objects to-be-used in future studies. 相似文献
103.
The fatty acid translocase gene CD36 and lingual lipase influence oral sensitivity to fat in obese subjects 总被引:1,自引:0,他引:1
The precise orosensory inputs engaged for dietary lipids detection in humans are unknown. We evaluated whether a common single nucleotide polymorphism (rs1761667) in the CD36 gene that reduces CD36 expression and the addition of orlistat, a lipase inhibitor, to reduce FA release from triacylglycerols (TGs), the main component of dietary fats, would attenuate fat orosensory sensitivity in humans. Twenty-one obese subjects with different rs1761667 genotypes (6 AA, 7 AG, and 8 GG) were studied on two occasions in which oleic acid and triolein orosensory detection thresholds were measured using emulsions prepared with and without orlistat. Subjects homozygous for the G-allele had 8-fold lower oral detection thresholds for oleic acid and triolein than subjects homozygous for the A allele, which associates with lower CD36 expression (P = 0.03). Thresholds for heterozygous subjects were intermediate. The addition of orlistat increased detection thresholds for triolein (log threshold = -0.3 ± 0.2 vs. 0.3 ± 0.1; P < 0.001) but not oleic acid (log threshold = -1.0 ± 0.2 vs. -0.8 ± 0.2; P > 0.2). In conclusion, this is the first experimental evidence for a role of CD36 in fat gustatory perception in humans. The data also support involvement of lingual lipase and are consistent with the concept that FA and not TG is the sensed stimulus. 相似文献
104.
Hagura N Hirose S Matsumura M Naito E 《Proceedings. Biological sciences / The Royal Society》2012,279(1742):3476-3481
When confronted with complex visual scenes in daily life, how do we know which visual information represents our own hand? We investigated the cues used to assign visual information to one''s own hand. Wrist tendon vibration elicits an illusory sensation of wrist movement. The intensity of this illusion attenuates when the actual motionless hand is visually presented. Testing what kind of visual stimuli attenuate this illusion will elucidate factors contributing to visual detection of one''s own hand. The illusion was reduced when a stationary object was shown, but only when participants knew it was controllable with their hands. In contrast, the visual image of their own hand attenuated the illusion even when participants knew that it was not controllable. We suggest that long-term knowledge about the appearance of the body and short-term knowledge about controllability of a visual object are combined to robustly extract our own body from a visual scene. 相似文献
105.
Mascalzoni E Osorio D Regolin L Vallortigara G 《Proceedings. Biological sciences / The Royal Society》2012,279(1730):841-846
Bilateral symmetry is visually salient to diverse animals including birds, but whereas experimental studies typically use bilaterally symmetrical two-dimensional patterns that are viewed approximately fronto-parallel; in nature, animals observe three-dimensional objects from all angles. Many animals and plant structures have a plane of bilateral symmetry. Here, we first (experiment I) give evidence that young poultry chicks readily generalize bilateral symmetry as a feature of two-dimensional patterns in fronto-parallel view. We then test the ability of chicks to recognize symmetry in images that would be produced by the transformed view produced by a 40° horizontal combined with a 20° vertical rotation of a pattern on a spherical surface. Experiment II gives evidence that chicks trained to distinguish symmetrical from asymmetrical patterns treat rotated views of symmetrical 'objects' as symmetrical. Experiment III gives evidence that chicks trained to discriminate rotated views of symmetrical 'objects' from asymmetrical patterns generalize to novel symmetrical objects either in fronto-parallel or rotated view. These findings emphasize the importance of bilateral symmetry for three-dimensional object recognition and raise questions about the underlying mechanisms of symmetry perception. 相似文献
106.
When a rubber hand is placed on a table top in a plausible position as if part of a person’s body, and is stroked synchronously with the person’s corresponding hidden real hand, an illusion of ownership over the rubber hand can occur (Botvinick and Cohen 1998). A similar result has been found with respect to a virtual hand portrayed in a virtual environment, a virtual hand illusion (Slater et al. 2008). The conditions under which these illusions occur have been the subject of considerable study. Here we exploited the flexibility of virtual reality to examine four contributory factors: visuo-tactile synchrony while stroking the virtual and the real arms, body continuity, alignment between the real and virtual arms, and the distance between them. We carried out three experiments on a total of 32 participants where these factors were varied. The results show that the subjective illusion of ownership over the virtual arm and the time to evoke this illusion are highly dependent on synchronous visuo-tactile stimulation and on connectivity of the virtual arm with the rest of the virtual body. The alignment between the real and virtual arms and the distance between these were less important. It was found that proprioceptive drift was not a sensitive measure of the illusion, but was only related to the distance between the real and virtual arms.
Electronic supplementary material
The online version of this article (doi:10.1007/s11571-011-9178-5) contains supplementary material, which is available to authorized users. 相似文献107.
Ozaki TJ Sato N Kitajo K Someya Y Anami K Mizuhara H Ogawa S Yamaguchi Y 《Cognitive neurodynamics》2012,6(2):185-198
An ambiguous figure such as the Necker cube causes spontaneous perceptual switching (SPS). The mechanism of SPS in multistable
perception has not yet been determined. Although early psychological studies suggested that SPS may be caused by fatigue or
satiation of orientation, the neural mechanism of SPS is still unknown. Functional magnetic resonance imaging (fMRI) has shown
that the dorsal attention network (DAN), which mainly controls voluntary attention, is involved in bistable perception of
the Necker cube. To determine whether neural dynamics along the DAN cause SPS, we performed simultaneous electroencephalography
(EEG) and fMRI during an SPS task with the Necker cube, with every SPS reported by pressing a button. This EEG–fMRI integrated
analysis showed that (a) 3–4 Hz spectral EEG power modulation at fronto-central, parietal, and centro-parietal electrode sites
sequentially appeared from 750 to 350 ms prior to the button press; and (b) activations correlating with the EEG modulation
traveled along the DAN from the frontal to the parietal regions. These findings suggest that slow oscillation initiates SPS
through global dynamics along the attentional system such as the DAN. 相似文献
108.
The neural representation of motion aftereffects induced by various visual flows (translational, rotational, motion-in-depth,
and translational transparent flows) was studied under the hypothesis that the imbalances in discharge activities would occur
in favor in the direction opposite to the adapting stimulation in the monkey MST cells (cells in the medial superior temporal
area) which can discriminate the mode (i.e., translational, rotational, or motion-in-depth) of the given flow. In single-unit
recording experiments conducted on anaesthetized monkeys, we found that the rate of spontaneous discharge and the sensitivity
to a test stimulus moving in the preferred direction decreased after receiving an adapting stimulation moving in the preferred
direction, whereas they increased after receiving an adapting stimulation moving in the null direction. To consistently explain
the bidirectional perception of a transparent visual flow and its unidirectional motion aftereffect by the same hypothesis,
we need to assume the existence of two subtypes of MST D cells which show directionally selective responses to a translational
flow: component cells and integration cells. Our physiological investigation revealed that the MST D cells could be divided
into two types: one responded to a transparent flow by two peaks at the instances when the direction of one of the component
flow matched the preferred direction of the cell, and the other responded by a single peak at the instance when the direction
of the integrated motion matched the preferred direction. In psychophysical experiments on human subjects, we found evidence
for the existence of component and integration representations in the human brain. To explain the different motion perceptions,
i.e., two transparent flows during presentation of the flows and a single flow in the opposite direction to the integrated
flows after stopping the flow stimuli, we suggest that the pattern-discrimination system can select the motion representation
that is consistent with the perception of the pattern from two motion representations. We discuss the computational aspects
related to the integration of component motion fields. 相似文献
109.
Karin Hauffen Eugene Bart Mark Brady Daniel Kersten Jay Hegdé 《Journal of visualized experiments : JoVE》2012,(69)
In order to quantitatively study object perception, be it perception by biological systems or by machines, one needs to create objects and object categories with precisely definable, preferably naturalistic, properties1. Furthermore, for studies on perceptual learning, it is useful to create novel objects and object categories (or object classes) with such properties2.Many innovative and useful methods currently exist for creating novel objects and object categories3-6 (also see refs. 7,8). However, generally speaking, the existing methods have three broad types of shortcomings.First, shape variations are generally imposed by the experimenter5,9,10, and may therefore be different from the variability in natural categories, and optimized for a particular recognition algorithm. It would be desirable to have the variations arise independently of the externally imposed constraints.Second, the existing methods have difficulty capturing the shape complexity of natural objects11-13. If the goal is to study natural object perception, it is desirable for objects and object categories to be naturalistic, so as to avoid possible confounds and special cases.Third, it is generally hard to quantitatively measure the available information in the stimuli created by conventional methods. It would be desirable to create objects and object categories where the available information can be precisely measured and, where necessary, systematically manipulated (or ''tuned''). This allows one to formulate the underlying object recognition tasks in quantitative terms.Here we describe a set of algorithms, or methods, that meet all three of the above criteria. Virtual morphogenesis (VM) creates novel, naturalistic virtual 3-D objects called ''digital embryos'' by simulating the biological process of embryogenesis14. Virtual phylogenesis (VP) creates novel, naturalistic object categories by simulating the evolutionary process of natural selection9,12,13. Objects and object categories created by these simulations can be further manipulated by various morphing methods to generate systematic variations of shape characteristics15,16. The VP and morphing methods can also be applied, in principle, to novel virtual objects other than digital embryos, or to virtual versions of real-world objects9,13. Virtual objects created in this fashion can be rendered as visual images using a conventional graphical toolkit, with desired manipulations of surface texture, illumination, size, viewpoint and background. The virtual objects can also be ''printed'' as haptic objects using a conventional 3-D prototyper.We also describe some implementations of these computational algorithms to help illustrate the potential utility of the algorithms. It is important to distinguish the algorithms from their implementations. The implementations are demonstrations offered solely as a ''proof of principle'' of the underlying algorithms. It is important to note that, in general, an implementation of a computational algorithm often has limitations that the algorithm itself does not have.Together, these methods represent a set of powerful and flexible tools for studying object recognition and perceptual learning by biological and computational systems alike. With appropriate extensions, these methods may also prove useful in the study of morphogenesis and phylogenesis. 相似文献
110.