Interneuron Accumulation of Phosphorylated tau Impairs Adult Hippocampal Neurogenesis by Suppressing GABAergic Transmission

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Spinal-cord plasticity

Plasticity is one of the most extensively studied aspects in neuroscience. Interest in it has primarily been related to its proposed role in learning and memory and its relevance to adaptive changes following injury. Plasticity can be evoked by changes in molecular, cellular, and synaptic properties, either as a result of activity-dependent effects, or by relatively slow-acting neuromodulatory transmitters. In addition, it is increasingly recognized that the plasticity evoked by these individual effects can be altered by previous inputs and is thus itself plastic. Here, I will review studies in the lamprey spinal cord that have examined individual and interactive activity-dependent and neuromodulator-mediated plasticity. The results show that activity-dependent and neuromodulator-mediated plasticity evoke neuron-and synapse-specific effects at different levels in the spinal cord, and that interactions within and between these effects can evoke dynamic changes in cellular, synaptic, and network plasticity.     

Subcellular mRNA localization and local translation of Arhgap11a in radial glial progenitors regulates cortical development

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Excitatory granule neuron precursors orchestrate laminar localization and differentiation of cerebellar inhibitory interneuron subtypes

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GABA-ergic Inhibition in the CNS: Types of GABA Receptors and Mechanisms of Tonic GABA-Mediated Inhibitory Action

This review considers such aspects of the problem of GABA-ergic inhibition in the CNS as the fundamental molecular mechanisms of GABA-ergic synaptic transmission, current questions on the principles underlying the classification of the GABA receptors, the diversity of the types of GABA-ergic inhibition, as well as possible mechanisms and functional importance of the tonic GABA-mediated inhibitory action.     

Inhibitory Kcnip2 neurons of the spinal dorsal horn control behavioral sensitivity to environmental cold

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