全文获取类型
收费全文 | 57146篇 |
免费 | 18506篇 |
国内免费 | 1310篇 |
出版年
2024年 | 83篇 |
2023年 | 495篇 |
2022年 | 560篇 |
2021年 | 1098篇 |
2020年 | 3473篇 |
2019年 | 5088篇 |
2018年 | 5268篇 |
2017年 | 5072篇 |
2016年 | 4866篇 |
2015年 | 4780篇 |
2014年 | 4723篇 |
2013年 | 5446篇 |
2012年 | 4288篇 |
2011年 | 4525篇 |
2010年 | 3957篇 |
2009年 | 2969篇 |
2008年 | 3156篇 |
2007年 | 2531篇 |
2006年 | 2555篇 |
2005年 | 2190篇 |
2004年 | 1783篇 |
2003年 | 1813篇 |
2002年 | 1579篇 |
2001年 | 1167篇 |
2000年 | 703篇 |
1999年 | 475篇 |
1998年 | 240篇 |
1997年 | 232篇 |
1996年 | 199篇 |
1995年 | 171篇 |
1994年 | 136篇 |
1993年 | 135篇 |
1992年 | 115篇 |
1991年 | 97篇 |
1990年 | 80篇 |
1989年 | 88篇 |
1988年 | 75篇 |
1987年 | 69篇 |
1986年 | 62篇 |
1985年 | 96篇 |
1984年 | 122篇 |
1983年 | 88篇 |
1982年 | 82篇 |
1981年 | 53篇 |
1980年 | 64篇 |
1979年 | 54篇 |
1978年 | 19篇 |
1977年 | 6篇 |
1974年 | 9篇 |
1973年 | 8篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
941.
942.
943.
Binglin Yue Haiyan Yang Jian Wang Wenxiu Ru Jiyao Wu Yongzheng Huang Xianyong Lan Chuzhao Lei Hong Chen 《Cell proliferation》2020,53(7)
Exosomes are membrane‐bound extracellular vesicles that are produced in the endosomal compartment of most mammalian cell types and then released. Exosomes are effective carriers for the intercellular material transfer of material that can influence a series of physiological and pathological processes in recipient cells. Among loaded cargoes, non‐coding RNAs (ncRNAs) vary for the exosome‐producing cell and its homeostatic state, and characterization of the biogenesis and secretion of exosomal ncRNAs and the functions of these ncRNAs in skeletal muscle myogenesis remain preliminary. In this review, we will describe what is currently known of exosome biogenesis, release and uptake of exosomal ncRNAs, as well as the varied functions of exosomal miRNAs in skeletal muscle myogenesis. 相似文献
944.
David S. Goodsell Christine Zardecki Luigi Di Costanzo Jose M. Duarte Brian P. Hudson Irina Persikova Joan Segura Chenghua Shao Maria Voigt John D. Westbrook Jasmine Y. Young Stephen K. Burley 《Protein science : a publication of the Protein Society》2020,29(1):52-65
Analyses of publicly available structural data reveal interesting insights into the impact of the three‐dimensional (3D) structures of protein targets important for discovery of new drugs (e.g., G‐protein‐coupled receptors, voltage‐gated ion channels, ligand‐gated ion channels, transporters, and E3 ubiquitin ligases). The Protein Data Bank (PDB) archive currently holds > 155,000 atomic‐level 3D structures of biomolecules experimentally determined using crystallography, nuclear magnetic resonance spectroscopy, and electron microscopy. The PDB was established in 1971 as the first open‐access, digital‐data resource in biology, and is now managed by the Worldwide PDB partnership (wwPDB; wwPDB.org ). US PDB operations are the responsibility of the Research Collaboratory for Structural Bioinformatics PDB (RCSB PDB). The RCSB PDB serves millions of RCSB.org users worldwide by delivering PDB data integrated with ~40 external biodata resources, providing rich structural views of fundamental biology, biomedicine, and energy sciences. Recently published work showed that the PDB archival holdings facilitated discovery of ~90% of the 210 new drugs approved by the US Food and Drug Administration 2010–2016. We review user‐driven development of RCSB PDB services, examine growth of the PDB archive in terms of size and complexity, and present examples and opportunities for structure‐guided drug discovery for challenging targets (e.g., integral membrane proteins). 相似文献
945.
《Current biology : CB》2020,30(21):4177-4187.e4
946.
947.
948.
949.
950.