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131.
摘要 目的:探讨前列腺影像报告和数据系统第2.1版(PI-RADS V2.1)评分联合血清前列腺特异抗原(PSA)相关指标对灰区前列腺癌的诊断价值。方法:回顾性分析2016年1月至2019年12月的187例经病理证实且PSA为灰区(4-10 ng/mL)的前列腺癌或前列腺增生患者资料。根据病理结果分为前列腺癌(PCa)组与前列腺增生组(BPH)组。由两名经验丰富的MRI诊断医师通过盲法对所有患者MRI图像进行PI-RADS V2.1评分,统计并计算血清PSA相关指标:总前列腺特异抗原(t-PSA)、游离前列腺特异抗原(f-PSA)、游离前列腺特异抗原与总前列腺特异抗原比值(f-PSA/t-PSA)、前列腺特异抗原密度(PSAD)。采用t检验比较各项指标在两组间的差异性,并使用受试者工作曲线(ROC)分析各项指标对灰区前列腺癌的诊断效能。结果:PI-RADS V2.1评分与PSAD在PCa与BPH组之间的差异具有统计学意义(P<0.05),而t-PSA、f-PSA、f-PSA/t-PSA在PCa与BPH组之间的差异均无统计学意义(P>0.05)。根据ROC曲线分析,PI-RADS V2.1评分、PSAD、PI-RADS V2.1评分联合PSAD诊断灰区前列腺癌的曲线下面积(AUC)分别为0.814、0.671及0.838,且PI-RADS V2.1评分联合PSAD的AUC显著高于单独应用PI-RADS V2.1评分(Z=1.989,P<0.05)与PSAD(Z=3.174,P<0.05)。结论:PI-RADS V2.1评分与PSAD对诊断灰区前列腺癌具有较高诊断效能,且联合PI-RADS V2.1评分与PSAD能进一步提高诊断效能。 相似文献
132.
Ami P. Jhaveri Allen Bale Niki Lovick Kaye Zuckerman Hari Deshpande Kristina Rath Peter Schwartz Erin W. Hofstatter 《The Yale journal of biology and medicine》2015,88(2):181-185
Li-Fraumeni syndrome is a rare cancer predisposition syndrome classically associated with remarkably early onset of cancer in families with a typical spectrum of malignancies, including sarcoma, breast cancer, brain tumors, and adrenocortical carcinoma. Because the risks of cancer development are strikingly high for Li-Fraumeni syndrome, aggressive cancer surveillance is often pursued in these individuals. However, optimal screening methods and intervals for Li-Fraumeni syndrome have yet to be determined. In addition, there may be a significant psychosocial burden to intensive cancer surveillance and some prevention modalities. Here, we describe a case of a young woman with a de novo mutation in TP53 and multiple malignancies, with her most recent cancers found at early, curable stages due to aggressive cancer screening. The potential benefits and risks of intensive cancer surveillance in hereditary cancer syndromes is discussed. 相似文献
133.
Ectrodactyly-ectodermal dysplasia-cleft (EEC) syndrome is an autosomal dominant disorder characterized by the triad of ectrodactyly, ectodermal dysplasia, and facial clefting. Even though literature has documented the association of various genetic disorders with aggressive periodontitis, the periodontal manifestations in patients with EEC syndrome have never been addressed. This case report presents the periodontal status of three patients in a family with EEC syndrome. The presence of generalized aggressive periodontitis was noticed in these patients. EEC syndrome could be a new addition to the group of genetic disorders associated with aggressive periodontitis. 相似文献
134.
The present study was performed to describe 2 human cases infected by the horsehair worm, Parachordodes sp., in Japan. Two gordiid worms were collected in the vomit and excreta of an 80-year-old woman in November 2009 in Kyoto city, and in the mouth of 1-year-old boy in December 2009 in Nara city, Japan, respectively. Both worms were males having bifurcated posterior ends and male gonads in cross sectional specimens. They were identified as Parachordodes sp. (Nematomorpha: Chordodidae) based on the characteristic morphologies of cross sections and areoles in the cuticle. DNA analysis on 18S rRNA partial sequence arrangements was also carried out and both worms were assumed to be close to the genus Paragordionus based on tree analysis, and far from Gordius sp. which has already been reported in humans in Japan. DNA sequencing of the Parachordodes worm does not appear on the database; therefore, more information on the gene sequences of the genus Parachordodes from humans, animals, or intermediates is required. 相似文献
135.
136.
Ján Hrvoľ Viera Horecká Jaroslav Škvarenina Katarína Střelcová Jana Škvareninová 《Biologia》2009,64(3):605-609
The paper presents the results of the model computation of actual and potential evapotranspiration as well as evaporation
measurements from the GGI-3000 Pan (evaporimeter) at 3 selected stations of Slovakia for the periods 1971–2000 (2 stations)
and 1986–2000 (1 station). The localities are situated in the most southern parts of Slovakia in 1st Oak stage and on southern slopes of the Carpathian promontories. A model computation of the monthly totals of actual and
potential evapotranspiration was performed by a common solution of energy and water balance equations of the top one-meter
layer of the soil. The model outputs are compared to the measurement data. The dependence of the ratio of actual evapotranspiration/
evaporation measured by the GGI-3000 Pan (E/E
p) on relative evapotranspiration (E/E
o), when E, E
o are calculated, is linear with a high correlation coefficient during the season from April to October. The paper also gives
the comparison results of the mean monthly and annual air temperatures, temperatures of active and saturated surface with
the mean monthly temperature of free water surface in the GGI-3000 Pan at these 3 stations (Bratislava-Koliba, Somotor and
Žihárec). It was found that the mean free water surface temperature for the period from April to October is close to the mean
temperature of saturated surface during that period. The mean temperatures of free water surface in the GGI-3000 Pan from
April to October tend to increase for the period 1971–2000. 相似文献
137.
We present here the estimation of the upper limit of the number of molecular targets in the human genome that represent an
opportunity for further therapeutic treatment. We select around ∼6300 human proteins that are similar to sequences of known
protein targets collected from DrugBank database. Our bioinformatics study estimates the size of ‘druggable’ human genome
to be around 20% of human proteome, i.e. the number of the possible protein targets for small-molecule drug design in medicinal
chemistry. We do not take into account any toxicity prediction, the three-dimensional characteristics of the active site in
the predicted ‘druggable’ protein families, or detailed chemical analysis of known inhibitors/drugs. Instead we rely on remote
homology detection method Meta-BASIC, which is based on sequence and structural similarity. The prepared dataset of all predicted
protein targets from human genome presents the unique opportunity for developing and benchmarking various in silico chemo/bio-informatics
methods in the context of the virtual high throughput screening. 相似文献
138.
139.
Park JH Chai JW Cho N Paek NS Guk SM Shin EH Chai JY 《The Korean journal of parasitology》2006,44(2):151-156
A case of breast sparganosis was confirmed by surgical excision of a worm (fragmented into 5 pieces) in a 59-year-old Korean woman suffering from a palpable mass in the left breast. Mammography and ultrasonography characteristically revealed the presence of several well-defined, isodense and hypoechoic tubular masses, in the upper quadrant of the left breast, each mass consisting of a continuous cord- or worm-like structure. During surgery, a long segment of an actively moving sparganum of Spirometra sp. and 4 small fragments of the same worm, giving a total length of 20.3 cm, were extracted from the upper outer quadrant of the left breast and the axillary region. The infection source remains unclear, because the patient denied ingesting any snake or frog meat or drinking untreated water. 相似文献
140.
Three cases of cutaneous larva migrans (CLM) were diagnosed in a returnee from a trip to Thailand and in 2 domestic farmers during July and September, 2003. The linear and serpiginous skin lesions on the lower extremities were presented in all 3 cases. Routine laboratory findings were normal. In the imported case, a 650 x 30 micrometer sized filariform nematode larva, presumably a species of hookworm, was detected in the lesion. All cases were treated with 400 mg albendazole once daily for 3-5 days, and their skin lesions gradually improved. In the present study, a causative agent of CLM was isolated for the first time in the Republic of Korea. Moreover, we speculate that CLM is prevalent in farmers who are in frequent contact with soil in the Republic of Korea. 相似文献