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301.
302.
Roudabeh J. Jamasbi Eugene H. Perkins 《In vitro cellular & developmental biology. Plant》1990,26(3):222-228
Summary Seven cell lines established from a diethylnitrosamine (DEN)-induced forestomach carcinoma (DEN3) of a BALB/c mouse and its six pulmonary metastatic foci were used to study the biological and functional diversity of tumor
cells. DEN3 is a highly tumorigenic line capable of forming lung metastases readily. Six metastatic nodules were isolated from the lungs
of syngeneic mice and six cell lines were established. The cell lines differed in characteristics such as tumorigenicity,
metastatic capability, and in vivo and in vitro growth properties. Radiation sensitivity of these cell lines was examined
by exposure, at ner confluency stage of in vitro growth, to doses of 2.5 to 50 Gray (Gy) X-rays (1 Gy=100 rads). Shortly after
exposure (approximately 5 min), the cells were harvested and 105 cells were cultured or inoculated into syngeneic mice, or both. Growth of three of the six cell lines tested was prohibited
by 5 Gy. However, some populations from the other cell lines were able to survive 5 or 10 Gy. Progenies of the cells that
survived primary radiation exposure after several in vitro passages were able to withstand another exposure of the same magnitude
but not a higher dose. The X-rayed survivor cells also maintained their tumorigenic potential.
This work was supported by Biomedical Research Support grant 2-507-RR-071292-07 from the National Institute of Health, Bethesda,
MD; by the Ohio Board of Regents Research Challenge Grant; and an FRC grant. R. J. Jamasbi under Department of Energy Research
contract DE-ACOF-760-R00033 through Oak Ridge Associated Universities. 相似文献
303.
A panel of three monoclonal antibodies (MoAbs) was tested on 29 benign and 53 malignant effusions with the aim of investigating its usefulness for the discrimination between benign and malignant lesions. The panel consisted of MoAbs directed against epithelial membrane antigen (EMA); MCA-b-12, reacting with a 350 kD glycoprotein with mucin-like characteristics present on human breast cancer cells and various other normal and neoplastic tissues, and Ber-EP4, directed against a 34 and 39 kD glycopeptide on human epithelial cells but not on mesothelium. Fifty-two (98%) of the malignant effusions reacted with EMA, 49 (92%) with MCA-b-12 and 44 (83%) with Ber-EP4. Fourteen per cent of benign effusions reacted with EMA, 17% with MCA-b-12 and 7% with Ber-EP4. All seven effusions obtained from patients with a malignant mesothelioma reacted with EMA, six of the seven cases staining intensively. None of the seven stained with Ber-EP4. MCA-b-12 did not react with the cells in one case of malignant mesothelioma. The results suggest that the combination of EMA and Ber-EP4 may be used to discriminate between benign and malignant cells and possibly also between adenocarcinoma and malignant mesothelioma. MCA-b-12 followed in general the reaction pattern of EMA, although often with a less intense staining reaction, making this antibody unsuitable for inclusion in the panel. 相似文献